| UniProt ID | RSC6_YEAST | |
|---|---|---|
| UniProt AC | P25632 | |
| Protein Name | Chromatin structure-remodeling complex protein RSC6 | |
| Gene Name | RSC6 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 483 | |
| Subcellular Localization | Nucleus . Localizes to centromeric and flanking chromatin. Association with these loci is dependent on STH1. | |
| Protein Description | Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and suppresses formamide sensitivity of the RSC8 mutants.. | |
| Protein Sequence | MVTQTNPVPVTYPTDAYIPTYLPDDKVSNLADLKKLIEMDSRLDLYLTRRRLDTSINLPTNTKTKDHPPNKEMLRIYVYNTTESSPRSDSGTPADSGKTTWTLRIEGKLLHESANGKHPFSEFLEGVAVDFKRLKPLGMGKKRKRDSSLSLPLNLQQPEYNDQDSTMGDNDNGEDEDSAEAESREEIVDALEWNYDENNVVEFDGIDIKRQGKDNLRCSITIQLRGVDGGKVQYSPNLATLIGMQTGSVNDAVYSIYKYILINNLFVTEQTEAQDGSNDAEDSSNENNNKNGAGDDDGVEGSTPKDKPELGEVKLDSLLQKVLDTNAAHLPLMNVVQTVNKLVSPLPPIILDYTIDLSKDTTYGATTLDVDVSHILHQPQPQPNLQKEEETDAEDTAKLREITKLALQLNSSAQKYQFFHELSLHPRETLTHYLWSSKQNELVLQGDQYFNEDAARTSDIYSNNNNDRSLMGNISLLYSQGRL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 20 | Phosphorylation | PTDAYIPTYLPDDKV CCCCCCCCCCCCCCC | 28.29 | 28889911 | |
| 21 | Phosphorylation | TDAYIPTYLPDDKVS CCCCCCCCCCCCCCC | 15.75 | 28889911 | |
| 54 | Phosphorylation | LTRRRLDTSINLPTN HHHHCCCCCCCCCCC | 35.78 | 28889911 | |
| 60 | Phosphorylation | DTSINLPTNTKTKDH CCCCCCCCCCCCCCC | 59.70 | 28889911 | |
| 62 | Phosphorylation | SINLPTNTKTKDHPP CCCCCCCCCCCCCCC | 42.44 | 19779198 | |
| 81 | Phosphorylation | LRIYVYNTTESSPRS EEEEEEECCCCCCCC | 17.79 | 22369663 | |
| 82 | Phosphorylation | RIYVYNTTESSPRSD EEEEEECCCCCCCCC | 30.17 | 22369663 | |
| 84 | Phosphorylation | YVYNTTESSPRSDSG EEEECCCCCCCCCCC | 43.48 | 22369663 | |
| 85 | Phosphorylation | VYNTTESSPRSDSGT EEECCCCCCCCCCCC | 20.35 | 22369663 | |
| 88 | Phosphorylation | TTESSPRSDSGTPAD CCCCCCCCCCCCCCC | 39.24 | 22369663 | |
| 90 | Phosphorylation | ESSPRSDSGTPADSG CCCCCCCCCCCCCCC | 45.90 | 22369663 | |
| 92 | Phosphorylation | SPRSDSGTPADSGKT CCCCCCCCCCCCCCC | 21.18 | 22369663 | |
| 96 | Phosphorylation | DSGTPADSGKTTWTL CCCCCCCCCCCEEEE | 44.27 | 22369663 | |
| 98 | Acetylation | GTPADSGKTTWTLRI CCCCCCCCCEEEEEE | 46.89 | 24489116 | |
| 147 | Phosphorylation | GKKRKRDSSLSLPLN CCCCCCCCCCCCCCC | 36.89 | 19779198 | |
| 150 | Phosphorylation | RKRDSSLSLPLNLQQ CCCCCCCCCCCCCCC | 29.86 | 19779198 | |
| 160 | Phosphorylation | LNLQQPEYNDQDSTM CCCCCCCCCCCCCCC | 30.62 | 19779198 | |
| 234 | Phosphorylation | VDGGKVQYSPNLATL CCCCEEEECCCHHHH | 29.14 | 23607784 | |
| 235 | Phosphorylation | DGGKVQYSPNLATLI CCCEEEECCCHHHHH | 7.10 | 23607784 | |
| 240 | Phosphorylation | QYSPNLATLIGMQTG EECCCHHHHHCCCCC | 23.29 | 23607784 | |
| 246 | Phosphorylation | ATLIGMQTGSVNDAV HHHHCCCCCCHHHHH | 23.64 | 23607784 | |
| 248 | Phosphorylation | LIGMQTGSVNDAVYS HHCCCCCCHHHHHHH | 22.57 | 23607784 | |
| 254 | Phosphorylation | GSVNDAVYSIYKYIL CCHHHHHHHHHHHHH | 7.35 | 23607784 | |
| 255 | Phosphorylation | SVNDAVYSIYKYILI CHHHHHHHHHHHHHH | 16.91 | 23607784 | |
| 257 | Phosphorylation | NDAVYSIYKYILINN HHHHHHHHHHHHHCC | 7.56 | 23607784 | |
| 302 | Phosphorylation | DDDGVEGSTPKDKPE CCCCCCCCCCCCCCC | 28.20 | 21440633 | |
| 303 | Phosphorylation | DDGVEGSTPKDKPEL CCCCCCCCCCCCCCC | 45.26 | 27214570 | |
| 391 | Phosphorylation | NLQKEEETDAEDTAK CCCCCHHCCHHHHHH | 43.73 | 27717283 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RSC6_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RSC6_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RSC6_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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