dbPTM

ETT1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ETT1_YEAST
UniProt AC	Q08421
Protein Name	Enhancer of translation termination 1
Gene Name	ETT1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	412
Subcellular Localization	Nucleus .
Protein Description	Required for correct translation termination and probably involved in regulation of hypoxic gene expression in association TPA1. Inhibits replication of Brome mosaic virus..
Protein Sequence	MAKRPLGLGKQSREKKRKVESVEKKSDEPSRESTPVRSQMSVELDDDADLDDELAQLKGLWSKYFHSDRDDEYVLNGIVHECDRLLRLSEEDKEIKKTLNDIFHGIYALALSELTIFKAGDEEATEEKRKKDVSSFFESAIERVELGLSHFPESQFLKLVLAKIIFQRIPLEYISNLHLKSKDKKLDLVGQLEHGKKHFSIYENDTEFTFEILQMVNDLLDIVENFGREQSIQEGIDSDNEEEEELIDIELEPEHPVYPLQQSLEANYEWLRNHFDKLLDNTNTDVKIYASIANTLGELYLKKAEEPSKVFLSLQYDDGGSEKVSDKEAKNAQETALKHTKKALEYLEKAKLEDDPDTWVQVAEAYIDLGNLLDNESAEQEEAYKTAEEILGKANKASHGKFQDVLDNFLQG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Acetylation	KRPLGLGKQSREKKR CCCCCCCHHHHHHHH	50.58	25381059
24	Acetylation	RKVESVEKKSDEPSR HHHHHCCCCCCCCCC	56.26	25381059
26	Phosphorylation	VESVEKKSDEPSRES HHHCCCCCCCCCCCC	59.27	19823750
30	Phosphorylation	EKKSDEPSRESTPVR CCCCCCCCCCCCCCC	46.78	19823750
33	Phosphorylation	SDEPSRESTPVRSQM CCCCCCCCCCCCCCE	36.58	19823750
34	Phosphorylation	DEPSRESTPVRSQMS CCCCCCCCCCCCCEE	22.50	19823750
38	Phosphorylation	RESTPVRSQMSVELD CCCCCCCCCEEEECC	30.39	22369663
41	Phosphorylation	TPVRSQMSVELDDDA CCCCCCEEEECCCCC	12.56	22369663
130	Acetylation	EATEEKRKKDVSSFF HHCHHHHHHHHHHHH	65.48	24489116
131	Acetylation	ATEEKRKKDVSSFFE HCHHHHHHHHHHHHH	68.35	24489116
180	Acetylation	YISNLHLKSKDKKLD HHHHCCCCCCCCCCC	44.72	24489116
277	Acetylation	WLRNHFDKLLDNTNT HHHHHHHHHHHCCCC	50.43	24489116
313	Phosphorylation	EPSKVFLSLQYDDGG CCCCEEEEEEECCCC	11.27	28889911
401	Acetylation	ANKASHGKFQDVLDN HHHHHCCCHHHHHHH	34.13	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ETT1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ETT1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ETT1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
VAM6_YEAST	VAM6	physical	16554755
TPA1_YEAST	TPA1	physical	16554755

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ETT1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30; SER-33; THR-34;SER-41 AND SER-313, AND MASS SPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30; SER-33 AND THR-34,AND MASS SPECTROMETRY.	17563356 [Abstract]