| UniProt ID | VAM6_YEAST | |
|---|---|---|
| UniProt AC | Q07468 | |
| Protein Name | Vacuolar morphogenesis protein 6 | |
| Gene Name | VAM6 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1049 | |
| Subcellular Localization |
Vacuole membrane Peripheral membrane protein . |
|
| Protein Description | Required for vacuolar assembly. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion.. | |
| Protein Sequence | MLRAQKLHSLKSSDITAILPTEQSQKLVLAKKNGDVEVYSRDGNTLKLFQVYPDLLQNAKNDPLPPVIENFYFANELSTIFAQCKETLILLSTTNLHEYDRIIDRRGINHCWLFERSHKNKEEKNTYLIYSTINTAKMRVLIWEGRTYKNMMEASLSYRKETIRSIYPGETGITLATDLGIYHWPYNKPSLIRIEKTVKNKFPKDMISALTELKEQAEKVIEKKPKKNSHFDAQSFSSMDRMSRKSSMSSLWYRTIRNERGNKIRYTFELDGNDATPMIIDGATKKIFKVELMHNNEEPFLIATDHATFSESNSEFDHMQYLSSNLLMLYNSSTIKFVDYENGFTFLQQKIPEGIKWVKNLSGTYFLVWTSNDEVQLFSYHVDDGSEDDDQESICGDINDPDFYQLWRKVLFYKFFIDSPHSKELCVSDNPEESLDICAMKLRDLTVMWCLRIFDKFQNYMVQLERSRNSRMIRSKCEEMIIKSIFDLFIKFWAPPQLVILKVFPSAISSLVLEITGQEHHCLLKEAEEVKETYDIPPHLLNRWCLPYLTDTRRHLQNLLSKENDDESRITWCYRDREIKQSFDFFLISNHDDVDLNTMLTLIDTVLFKCYLYYNPPMVGPFIRVENHCDSHVIVTELKIRHMFKDLIDFYYKRGNHEEALKFLTDLVDELENDNTDQKQRQKIDHGVKILVIYYLKKLSNPQLDVIFTYTDWLLNRHNDSIKEILSSIFFYDSQACSSRDHLKVYGYIKKFDKLLAIQYLEFAISTFRLEGNKLHTVLIKLYLENLDIPSTRIKLKSLLETTSVYEPRTILKLLNDAIESGSDQLPTNQLNFVKYLKIFPLSKLENHKEAVHILLDEIDDYKAATSYCNDVYQSDSTKGEELLLYLYSKLVSIYDSNRNSKLILNFLQDHGSKLNSAEIYKNLPQDISLYDIGRVVSQLLKKHTSKMDETRLEKALLQVELVATTYKLNERMSSYGVLSDSHKCPICKKVISNFGTDSISWFTREGRNIITHYNCGKVLQERFNAKNEKSSRIKQKTLGEVINELNNK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 92 | Phosphorylation | KETLILLSTTNLHEY HHHEEEEECCCHHHH | 29.73 | 25371407 | |
| 93 | Phosphorylation | ETLILLSTTNLHEYD HHEEEEECCCHHHHH | 21.48 | 25371407 | |
| 94 | Phosphorylation | TLILLSTTNLHEYDR HEEEEECCCHHHHHH | 32.19 | 25371407 | |
| 147 | Phosphorylation | VLIWEGRTYKNMMEA EEEECCCHHHHHHHH | 50.10 | 27017623 | |
| 148 | Phosphorylation | LIWEGRTYKNMMEAS EEECCCHHHHHHHHH | 10.06 | 27017623 | |
| 155 | Phosphorylation | YKNMMEASLSYRKET HHHHHHHHHHHCHHH | 12.44 | 27017623 | |
| 157 | Phosphorylation | NMMEASLSYRKETIR HHHHHHHHHCHHHHH | 22.01 | 27017623 | |
| 235 | Phosphorylation | NSHFDAQSFSSMDRM CCCCCHHHCCCHHHH | 28.90 | 25704821 | |
| 237 | Phosphorylation | HFDAQSFSSMDRMSR CCCHHHCCCHHHHCC | 29.96 | 25704821 | |
| 238 | Phosphorylation | FDAQSFSSMDRMSRK CCHHHCCCHHHHCCH | 23.77 | 23749301 | |
| 243 | Phosphorylation | FSSMDRMSRKSSMSS CCCHHHHCCHHHHHH | 37.13 | 24961812 | |
| 247 | Phosphorylation | DRMSRKSSMSSLWYR HHHCCHHHHHHHHHH | 26.22 | 28889911 | |
| 249 | Phosphorylation | MSRKSSMSSLWYRTI HCCHHHHHHHHHHHH | 24.99 | 19779198 | |
| 250 | Phosphorylation | SRKSSMSSLWYRTIR CCHHHHHHHHHHHHH | 17.80 | 19779198 | |
| 253 | Phosphorylation | SSMSSLWYRTIRNER HHHHHHHHHHHHCCC | 11.81 | 27017623 | |
| 484 | Phosphorylation | CEEMIIKSIFDLFIK HHHHHHHHHHHHHHH | 20.34 | 27017623 | |
| 806 | Phosphorylation | LLETTSVYEPRTILK HHHCCCCCCCHHHHH | 21.71 | 28132839 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VAM6_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VAM6_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VAM6_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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