SMC2_YEAST - dbPTM
SMC2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SMC2_YEAST
UniProt AC P38989
Protein Name Structural maintenance of chromosomes protein 2
Gene Name SMC2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1170
Subcellular Localization Nucleus. Cytoplasm. Chromosome. In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromos
Protein Description Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases..
Protein Sequence MKVEELIIDGFKSYATRTVITDWDPQFNAITGLNGSGKSNILDAICFVLGIASMSTVRASSLQDLIYKRGQAGVTKASVTIVFDNTDKSNSPIGFTNSPQISVTRQVVLGGTSKYLINGHRAPQQSVLQLFQSVQLNINNPNFLIMQGKITKVLNMKPSEILSLIEEAAGTKMFEDRREKAERTMSKKETKLQENRTLLTEEIEPKLEKLRNEKRMFLEFQSTQTDLEKTERIVVSYEYYNIKHKHTSIRETLENGETRMKMLNEFVKKTSEEIDSLNEDVEEIKLQKEKELHKEGTISKLENKENGLLNEISRLKTSLSIKVENLNDTTEKSKALESEIASSSAKLIEKKSAYANTEKDYKMVQEQLSKQRDLYKRKEELVSTLTTGISSTGAADGGYNAQLAKAKTELNEVSLAIKKSSMKMELLKKELLTIEPKLKEATKDNELNVKHVKQCQETCDKLRARLVEYGFDPSRIKDLKQREDKLKSHYYQTCKNSEYLKRRVTNLEFNYTKPYPNFEASFVHGVVGQLFQIDNDNIRYATALQTCAGGRLFNVVVQDSQTATQLLERGRLRKRVTIIPLDKIYTRPISSQVLDLAKKIAPGKVELAINLIRFDESITKAMEFIFGNSLICEDPETAKKITFHPKIRARSITLQGDVYDPEGTLSGGSRNTSESLLVDIQKYNQIQKQIETIQADLNHVTEELQTQYATSQKTKTIQSDLNLSLHKLDLAKRNLDANPSSQIIARNEEILRDIGECENEIKTKQMSLKKCQEEVSTIEKDMKEYDSDKGSKLNELKKELKLLAKELEEQESESERKYDLFQNLELETEQLSSELDSNKTLLHNHLKSIESLKLENSDLEGKIRGVEDDLVTVQTELNEEKKRLMDIDDELNELETLIKKKQDEKKSSELELQKLVHDLNKYKSNTNNMEKIIEDLRQKHEFLEDFDLVRNIVKQNEGIDLDTYRERSKQLNEKFQELRKKVNPNIMNMIENVEKKEAALKTMIKTIEKDKMKIQETISKLNEYKRETLVKTWEKVTLDFGNIFADLLPNSFAKLVPCEGKDVTQGLEVKVKLGNIWKESLIELSGGQRSLIALSLIMALLQFRPAPMYILDEVDAALDLSHTQNIGHLIKTRFKGSQFIVVSLKEGMFANANRVFRTRFQDGTSVVSIM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
67PhosphorylationSSLQDLIYKRGQAGV
HHHHHHHHHCCCCCC		11.2628132839
390PhosphorylationSTLTTGISSTGAADG
HHHHHCCCCCCCCCC		24.1627017623
391PhosphorylationTLTTGISSTGAADGG
HHHHCCCCCCCCCCC		29.0127017623
399PhosphorylationTGAADGGYNAQLAKA
CCCCCCCHHHHHHHH		16.9227017623
505PhosphorylationEYLKRRVTNLEFNYT
HHHHHHHCEEECCCC		32.0728889911
590PhosphorylationKIYTRPISSQVLDLA
HHCCCCCCHHHHHHH		19.8727017623
629PhosphorylationMEFIFGNSLICEDPE
HHHHHCCCCCCCCHH		21.3527017623
642PhosphorylationPETAKKITFHPKIRA
HHHHHHCEECHHHCC		25.4427017623
741PhosphorylationNLDANPSSQIIARNE
CCCCCCHHHHHHCCH		27.0127214570
907PhosphorylationKKQDEKKSSELELQK
HHHCHHCCCHHHHHH		39.8630377154
1005AcetylationAALKTMIKTIEKDKM
HHHHHHHHHHHHHHH		32.4025381059
1085PhosphorylationKESLIELSGGQRSLI
HHHHECCCCCHHHHH		28.2528889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SMC2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SMC2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SMC2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SMC4_YEASTSMC4physical
10811823
SMC4_YEASTSMC4physical
12719426
SPC29_YEASTSPC29physical
11087867
NDC80_YEASTNDC80genetic
10409732
ULP2_YEASTULP2genetic
11333221
RAD52_YEASTRAD52genetic
15793567
SMC6_YEASTSMC6genetic
15793567
CDC15_YEASTCDC15genetic
15657393
SMC4_YEASTSMC4physical
16554755
CND1_YEASTYCS4physical
16554755
HSP71_YEASTSSA1physical
19536198
SSB1_YEASTSSB1physical
19536198
BUB1_YEASTBUB1genetic
17825050
MAD3_YEASTMAD3genetic
17825050
CND1_YEASTYCS4genetic
17825050
CND2_YEASTBRN1genetic
17825050
SKP1_YEASTSKP1genetic
17825050
SGO1_YEASTSGO1genetic
17825050
CIN8_YEASTCIN8genetic
18923139
KAR3_YEASTKAR3genetic
18923139
SAC7_YEASTSAC7genetic
18923139
ASE1_YEASTASE1genetic
18923139
RT103_YEASTRTT103genetic
18923139
MAS5_YEASTYDJ1genetic
18923139
CSM1_YEASTCSM1genetic
18923139
LRS4_YEASTLRS4genetic
18923139
TOF2_YEASTTOF2genetic
18923139
TOP1_YEASTTOP1genetic
18923139
FOB1_YEASTFOB1genetic
18923139
CTF4_YEASTCTF4genetic
18923139
RAD50_YEASTRAD50genetic
18923139
CSM3_YEASTCSM3genetic
18923139
RTC4_YEASTRTC4genetic
18923139
IRC15_YEASTIRC15genetic
18923139
SSD1_YEASTSSD1genetic
11333221
MAD1_YEASTMAD1genetic
21441928
RM01_YEASTMRPL1genetic
21572441
NOP19_YEASTNOP19genetic
21572441
FOB1_YEASTFOB1genetic
19362534
CSM1_YEASTCSM1genetic
19362534
TOF2_YEASTTOF2genetic
19362534
LRS4_YEASTLRS4genetic
19362534
SMC4_YEASTSMC4physical
26904946
RRP1_YEASTRRP1genetic
27708008
NOP56_YEASTNOP56genetic
27708008
PROF_YEASTPFY1genetic
27708008
CND2_YEASTBRN1genetic
27708008
KPC1_YEASTPKC1genetic
27708008
SCC1_YEASTMCD1genetic
27708008
MPS1_YEASTMPS1genetic
27708008
RPN5_YEASTRPN5genetic
27708008
NOP14_YEASTNOP14genetic
27708008
GLE1_YEASTGLE1genetic
27708008
DBF4_YEASTDBF4genetic
27708008
SNU56_YEASTSNU56genetic
27708008
SRPR_YEASTSRP101genetic
27708008
SMT3_YEASTSMT3genetic
27708008
PANK_YEASTCAB1genetic
27708008
PSB3_YEASTPUP3genetic
27708008
ERG26_YEASTERG26genetic
27708008
NUP57_YEASTNUP57genetic
27708008
BRL1_YEASTBRL1genetic
27708008
ORC6_YEASTORC6genetic
27708008
YJ9I_YEASTYJR141Wgenetic
27708008
ERG27_YEASTERG27genetic
27708008
CDC42_YEASTCDC42genetic
27708008
GSP1_YEASTGSP1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
SEC39_YEASTSEC39genetic
27708008
UTP15_YEASTUTP15genetic
27708008
HAS1_YEASTHAS1genetic
27708008
NOP2_YEASTNOP2genetic
27708008
DPOA_YEASTPOL1genetic
27708008
RIB2_YEASTRIB2genetic
27708008
SEC63_YEASTSEC63genetic
27708008
PRS10_YEASTRPT4genetic
27708008
RRS1_YEASTRRS1genetic
27708008
SRP54_YEASTSRP54genetic
27708008
IWS1_YEASTSPN1genetic
27708008
CND3_YEASTYCG1physical
27463097
H2A1_YEASTHTA1genetic
29580382
H2B1_YEASTHTB1genetic
29580382
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SMC2_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1085, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory