| UniProt ID | SSD1_YEAST | |
|---|---|---|
| UniProt AC | P24276 | |
| Protein Name | Protein SSD1 | |
| Gene Name | SSD1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1250 | |
| Subcellular Localization | ||
| Protein Description | Can suppress the lethality due to deletion of SIT4, and partially the defects due to BCY1 disruption. Is implicated in the control of the cell cycle G1 phase.. | |
| Protein Sequence | MSKNSNVNNNRSQEPNNMFVQTTGGGKNAPKQIHVAHRRSQSELTNLMIEQFTLQKQLEQVQAQQQQLMAQQQQLAQQTGQYLSGNSGSNNHFTPQPPHPHYNSNGNSPGMSAGGSRSRTHSRNNSGYYHNSYDNNNNSNNPGSNSHRKTSSQSSIYGHSRRHSLGLNEAKKAAAEEQAKRISGGEAGVTVKIDSVQADSGSNSTTEQSDFKFPPPPNAHQGHRRATSNLSPPSFKFPPNSHGDNDDEFIATSSTHRRSKTRNNEYSPGINSNWRNQSQQPQQQLSPFRHRGSNSRDYNSFNTLEPPAIFQQGHKHRASNSSVHSFSSQGNNNGGGRKSLFAPYLPQANIPELIQEGRLVAGILRVNKKNRSDAWVSTDGALDADIYICGSKDRNRALEGDLVAVELLVVDDVWESKKEKEEKKRRKDASMQHDLIPLNSSDDYHNDASVTAATSNNFLSSPSSSDSLSKDDLSVRRKRSSTINNDSDSLSSPTKSGVRRRSSLKQRPTQKKNDDVEVEGQSLLLVEEEEINDKYKPLYAGHVVAVLDRIPGQLFSGTLGLLRPSQQANSDNNKPPQSPKIAWFKPTDKKVPLIAIPTELAPKDFVENADKYSEKLFVASIKRWPITSLHPFGILVSELGDIHDPDTEIDSILRDNNFLSNEYLDQKNPQKEKPSFQPLPLTAESLEYRRNFTDTNEYNIFAISELGWVSEFALHVRNNGNGTLELGCHVVDVTSHIEEGSSVDRRARKRSSAVFMPQKLVNLLPQSFNDELSLAPGKESATLSVVYTLDSSTLRIKSTWVGESTISPSNILSLEQLDEKLSTGSPTSYLSTVQEIARSFYARRINDPEATLLPTLSLLESLDDEKVKVDLNILDRTLGFVVINEIKRKVNSTVAEKIYTKLGDLALLRRQMQPIATKMASFRKKIQNFGYNFDTNTADELIKGVLKIKDDDVRVGIEILLFKTMPRARYFIAGKVDPDQYGHYALNLPIYTHFTAPMRRYADHVVHRQLKAVIHDTPYTEDMEALKITSEYCNFKKDCAYQAQEQAIHLLLCKTINDMGNTTGQLLTMATVLQVYESSFDVFIPEFGIEKRVHGDQLPLIKAEFDGTNRVLELHWQPGVDSATFIPADEKNPKSYRNSIKNKFRSTAAEIANIELDKEAESEPLISDPLSKELSDLHLTVPNLRLPSASDNKQNALEKFISTTETRIENDNYIQEIHELQKIPILLRAEVGMALPCLTVRALNPFMKRV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSKNSNVNN ------CCCCCCCCC | 52.42 | 22814378 | |
| 23 | Phosphorylation | NNMFVQTTGGGKNAP CCEEEEECCCCCCCC | 19.42 | 21551504 | |
| 40 | Phosphorylation | IHVAHRRSQSELTNL EEECCCCCHHHHHHH | 37.71 | 22369663 | |
| 42 | Phosphorylation | VAHRRSQSELTNLMI ECCCCCHHHHHHHHH | 35.50 | 22369663 | |
| 45 | Phosphorylation | RRSQSELTNLMIEQF CCCHHHHHHHHHHHH | 23.43 | 22890988 | |
| 53 | Phosphorylation | NLMIEQFTLQKQLEQ HHHHHHHHHHHHHHH | 28.15 | 22890988 | |
| 120 | Phosphorylation | AGGSRSRTHSRNNSG CCCCCCCCCCCCCCC | 26.00 | 28889911 | |
| 126 | Phosphorylation | RTHSRNNSGYYHNSY CCCCCCCCCCCCCCC | 31.55 | 22369663 | |
| 128 | Phosphorylation | HSRNNSGYYHNSYDN CCCCCCCCCCCCCCC | 11.02 | 22369663 | |
| 129 | Phosphorylation | SRNNSGYYHNSYDNN CCCCCCCCCCCCCCC | 9.69 | 19779198 | |
| 132 | Phosphorylation | NSGYYHNSYDNNNNS CCCCCCCCCCCCCCC | 22.13 | 22369663 | |
| 133 | Phosphorylation | SGYYHNSYDNNNNSN CCCCCCCCCCCCCCC | 28.18 | 22369663 | |
| 139 | Phosphorylation | SYDNNNNSNNPGSNS CCCCCCCCCCCCCCC | 39.86 | 22369663 | |
| 144 | Phosphorylation | NNSNNPGSNSHRKTS CCCCCCCCCCCCCCC | 36.09 | 22369663 | |
| 146 | Phosphorylation | SNNPGSNSHRKTSSQ CCCCCCCCCCCCCCC | 26.77 | 22369663 | |
| 150 | Phosphorylation | GSNSHRKTSSQSSIY CCCCCCCCCCCCHHH | 33.30 | 22890988 | |
| 151 | Phosphorylation | SNSHRKTSSQSSIYG CCCCCCCCCCCHHHC | 29.43 | 22890988 | |
| 152 | Phosphorylation | NSHRKTSSQSSIYGH CCCCCCCCCCHHHCH | 39.04 | 22369663 | |
| 154 | Phosphorylation | HRKTSSQSSIYGHSR CCCCCCCCHHHCHHH | 22.20 | 22890988 | |
| 155 | Phosphorylation | RKTSSQSSIYGHSRR CCCCCCCHHHCHHHH | 16.52 | 22369663 | |
| 157 | Phosphorylation | TSSQSSIYGHSRRHS CCCCCHHHCHHHHHC | 15.67 | 22890988 | |
| 160 | Phosphorylation | QSSIYGHSRRHSLGL CCHHHCHHHHHCCCH | 27.01 | 22890988 | |
| 164 | Phosphorylation | YGHSRRHSLGLNEAK HCHHHHHCCCHHHHH | 23.48 | 22369663 | |
| 183 | Phosphorylation | EEQAKRISGGEAGVT HHHHHHHHCCCCCCE | 44.79 | 22369663 | |
| 190 | Phosphorylation | SGGEAGVTVKIDSVQ HCCCCCCEEEEEEEE | 18.37 | 29688323 | |
| 202 | Phosphorylation | SVQADSGSNSTTEQS EEECCCCCCCCCCCC | 31.40 | 28889911 | |
| 204 | Phosphorylation | QADSGSNSTTEQSDF ECCCCCCCCCCCCCC | 38.10 | 28889911 | |
| 205 | Phosphorylation | ADSGSNSTTEQSDFK CCCCCCCCCCCCCCC | 38.31 | 30377154 | |
| 227 | Phosphorylation | HQGHRRATSNLSPPS CCCCCCCCCCCCCCC | 19.14 | 29136822 | |
| 228 | Phosphorylation | QGHRRATSNLSPPSF CCCCCCCCCCCCCCC | 34.49 | 21082442 | |
| 231 | Phosphorylation | RRATSNLSPPSFKFP CCCCCCCCCCCCCCC | 38.73 | 25533186 | |
| 234 | Phosphorylation | TSNLSPPSFKFPPNS CCCCCCCCCCCCCCC | 44.44 | 29136822 | |
| 252 | Phosphorylation | NDDEFIATSSTHRRS CCCCEEECCCCCCCC | 20.56 | 28889911 | |
| 255 | Phosphorylation | EFIATSSTHRRSKTR CEEECCCCCCCCCCC | 21.11 | 28889911 | |
| 261 | Phosphorylation | STHRRSKTRNNEYSP CCCCCCCCCCCCCCC | 39.62 | 29136822 | |
| 266 | Phosphorylation | SKTRNNEYSPGINSN CCCCCCCCCCCCCCC | 23.45 | 19779198 | |
| 267 | Phosphorylation | KTRNNEYSPGINSNW CCCCCCCCCCCCCCC | 15.52 | 22369663 | |
| 278 | Phosphorylation | NSNWRNQSQQPQQQL CCCCCCCCCCCCHHC | 34.04 | 22890988 | |
| 286 | Phosphorylation | QQPQQQLSPFRHRGS CCCCHHCCCCCCCCC | 20.04 | 22369663 | |
| 293 | Phosphorylation | SPFRHRGSNSRDYNS CCCCCCCCCCCCCCC | 31.43 | 19962308 | |
| 295 | Phosphorylation | FRHRGSNSRDYNSFN CCCCCCCCCCCCCCC | 28.38 | 28889911 | |
| 298 | Phosphorylation | RGSNSRDYNSFNTLE CCCCCCCCCCCCCCC | 16.17 | 19684113 | |
| 300 | Phosphorylation | SNSRDYNSFNTLEPP CCCCCCCCCCCCCCC | 17.40 | 28889911 | |
| 303 | Phosphorylation | RDYNSFNTLEPPAIF CCCCCCCCCCCCHHH | 30.41 | 27017623 | |
| 315 | Acetylation | AIFQQGHKHRASNSS HHHCCCCCCCCCCCC | 41.43 | 24489116 | |
| 319 | Phosphorylation | QGHKHRASNSSVHSF CCCCCCCCCCCCCEE | 36.88 | 29136822 | |
| 321 | Phosphorylation | HKHRASNSSVHSFSS CCCCCCCCCCCEECC | 31.10 | 29136822 | |
| 322 | Phosphorylation | KHRASNSSVHSFSSQ CCCCCCCCCCEECCC | 28.27 | 21551504 | |
| 325 | Phosphorylation | ASNSSVHSFSSQGNN CCCCCCCEECCCCCC | 25.35 | 29136822 | |
| 327 | Phosphorylation | NSSVHSFSSQGNNNG CCCCCEECCCCCCCC | 25.43 | 29136822 | |
| 328 | Phosphorylation | SSVHSFSSQGNNNGG CCCCEECCCCCCCCC | 39.85 | 29136822 | |
| 338 | Ubiquitination | NNNGGGRKSLFAPYL CCCCCCCCCCCCCCC | 55.58 | 15699485 | |
| 440 | Phosphorylation | HDLIPLNSSDDYHND CCCCCCCCCCCCCCC | 42.71 | 21440633 | |
| 454 | Phosphorylation | DASVTAATSNNFLSS CCCCEEECCCCCCCC | 29.53 | 21440633 | |
| 455 | Phosphorylation | ASVTAATSNNFLSSP CCCEEECCCCCCCCC | 25.67 | 21440633 | |
| 460 | Phosphorylation | ATSNNFLSSPSSSDS ECCCCCCCCCCCCCC | 35.74 | 24961812 | |
| 461 | Phosphorylation | TSNNFLSSPSSSDSL CCCCCCCCCCCCCCC | 30.83 | 20377248 | |
| 463 | Phosphorylation | NNFLSSPSSSDSLSK CCCCCCCCCCCCCCH | 44.41 | 21440633 | |
| 464 | Phosphorylation | NFLSSPSSSDSLSKD CCCCCCCCCCCCCHH | 41.36 | 20377248 | |
| 465 | Phosphorylation | FLSSPSSSDSLSKDD CCCCCCCCCCCCHHH | 35.24 | 20377248 | |
| 474 | Phosphorylation | SLSKDDLSVRRKRSS CCCHHHHHHHHHHCC | 22.14 | 24961812 | |
| 480 | Phosphorylation | LSVRRKRSSTINNDS HHHHHHHCCCCCCCC | 34.56 | 22369663 | |
| 481 | Phosphorylation | SVRRKRSSTINNDSD HHHHHHCCCCCCCCC | 37.02 | 22369663 | |
| 482 | Phosphorylation | VRRKRSSTINNDSDS HHHHHCCCCCCCCCC | 29.04 | 22369663 | |
| 487 | Phosphorylation | SSTINNDSDSLSSPT CCCCCCCCCCCCCCC | 31.09 | 22369663 | |
| 489 | Phosphorylation | TINNDSDSLSSPTKS CCCCCCCCCCCCCHH | 33.82 | 22369663 | |
| 491 | Phosphorylation | NNDSDSLSSPTKSGV CCCCCCCCCCCHHHH | 37.92 | 22369663 | |
| 492 | Phosphorylation | NDSDSLSSPTKSGVR CCCCCCCCCCHHHHH | 41.71 | 22369663 | |
| 494 | Phosphorylation | SDSLSSPTKSGVRRR CCCCCCCCHHHHHCC | 39.53 | 22369663 | |
| 496 | Phosphorylation | SLSSPTKSGVRRRSS CCCCCCHHHHHCCHH | 45.02 | 28889911 | |
| 502 | Phosphorylation | KSGVRRRSSLKQRPT HHHHHCCHHCCCCCC | 37.91 | 19795423 | |
| 503 | Phosphorylation | SGVRRRSSLKQRPTQ HHHHCCHHCCCCCCC | 37.46 | 19795423 | |
| 578 | Phosphorylation | DNNKPPQSPKIAWFK CCCCCCCCCCEEEEC | 33.65 | 28889911 | |
| 620 | Phosphorylation | SEKLFVASIKRWPIT CCHHHHHCCCCCCCC | 24.28 | 29734811 | |
| 660 | Phosphorylation | LRDNNFLSNEYLDQK HHCCCCCCHHHHCCC | 24.39 | 23749301 | |
| 667 | Ubiquitination | SNEYLDQKNPQKEKP CHHHHCCCCCCCCCC | 70.97 | 23749301 | |
| 685 | Phosphorylation | PLPLTAESLEYRRNF CCCCCHHHHHHHHCC | 24.84 | 17563356 | |
| 688 | Phosphorylation | LTAESLEYRRNFTDT CCHHHHHHHHCCCCC | 21.84 | 21082442 | |
| 751 | Phosphorylation | DRRARKRSSAVFMPQ CHHHHHHHCCCCCCH | 26.19 | 28889911 | |
| 780 | Phosphorylation | SLAPGKESATLSVVY CCCCCCCCEEEEEEE | 30.00 | 28889911 | |
| 788 | Phosphorylation | ATLSVVYTLDSSTLR EEEEEEEEECCCCEE | 16.69 | 22369663 | |
| 791 | Phosphorylation | SVVYTLDSSTLRIKS EEEEEECCCCEEEEE | 28.47 | 22369663 | |
| 792 | Phosphorylation | VVYTLDSSTLRIKST EEEEECCCCEEEEEE | 31.00 | 22369663 | |
| 793 | Phosphorylation | VYTLDSSTLRIKSTW EEEECCCCEEEEEEE | 24.81 | 22369663 | |
| 822 | Phosphorylation | EQLDEKLSTGSPTSY HHHHHHHCCCCCCHH | 41.61 | 21126336 | |
| 892 | Phosphorylation | EIKRKVNSTVAEKIY HHHHHCCHHHHHHHH | 27.52 | 27017623 | |
| 897 | Acetylation | VNSTVAEKIYTKLGD CCHHHHHHHHHHHHH | 31.13 | 24489116 | |
| 901 | Acetylation | VAEKIYTKLGDLALL HHHHHHHHHHHHHHH | 33.24 | 24489116 | |
| 931 | Phosphorylation | KKIQNFGYNFDTNTA HHHHHCCCCCCCCCH | 14.44 | 21440633 | |
| 935 | Phosphorylation | NFGYNFDTNTADELI HCCCCCCCCCHHHHH | 30.26 | 21440633 | |
| 937 | Phosphorylation | GYNFDTNTADELIKG CCCCCCCCHHHHHHH | 37.26 | 21440633 | |
| 1102 | Acetylation | GDQLPLIKAEFDGTN CCCCCEEEEECCCCC | 49.93 | 24489116 | |
| 1131 | Acetylation | TFIPADEKNPKSYRN CEECCCCCCCHHHHH | 78.19 | 24489116 | |
| 1139 | Phosphorylation | NPKSYRNSIKNKFRS CCHHHHHHHHHHHHH | 26.41 | 25704821 | |
| 1162 | Phosphorylation | ELDKEAESEPLISDP CCCHHHHCCCCCCCC | 52.11 | 24961812 | |
| 1175 | Phosphorylation | DPLSKELSDLHLTVP CCCCHHHHHCCCCCC | 38.94 | 22369663 | |
| 1180 | Phosphorylation | ELSDLHLTVPNLRLP HHHHCCCCCCCCCCC | 24.14 | 22369663 | |
| 1188 | Phosphorylation | VPNLRLPSASDNKQN CCCCCCCCCCCCHHH | 45.02 | 22369663 | |
| 1190 | Phosphorylation | NLRLPSASDNKQNAL CCCCCCCCCCHHHHH | 46.16 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SSD1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SSD1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SSD1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40; SER-183; SER-231;SER-267; SER-286; SER-461; SER-463; SER-480; SER-481; THR-482;SER-487; SER-489; SER-491; SER-492; THR-494; TYR-688 AND SER-1175, ANDMASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164; SER-183; SER-231;SER-492; SER-685 AND SER-1175, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164 AND SER-492, ANDMASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183, AND MASSSPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-482 AND SER-492, ANDMASS SPECTROMETRY. | |
