| UniProt ID | PDP1_YEAST | |
|---|---|---|
| UniProt AC | Q12511 | |
| Protein Name | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial | |
| Gene Name | PTC5 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 572 | |
| Subcellular Localization | Mitochondrion intermembrane space . | |
| Protein Description | Catalyzes the dephosphorylation and concomitant reactivation of the E1 alpha subunit (PDA1) of the pyruvate dehydrogenase complex.. | |
| Protein Sequence | MSPLTRTVAIKKTVKVLSKCQSGREYTQKFLQRAYSTSHANSTYYSRTKLFISSHSKALNIALLSGSLLLTYSYYSPKKILSLDTINGIKDYSTNTSGNINMPSPNPKGTETQKSQRSQNDQSVLILNDSKIEAKLHDREESHFVNRGTGIFRYDVAQLPSNHPIEDDHVEQIITIPIESEDGKSIEKDLYFFGIFDGHGGPFTSEKLSKDLVRYVAYQLGQVYDQNKTVFHSDPNQLIDSAISKGFLKLDNDLVIESFRKLFQDPNNTNIANTLPAISGSCALLSLYNSTNSILKVAVTGDSRALICGLDNEGNWTVKSLSTDQTGDNLDEVRRIRKEHPGEPNVIRNGRILGSLQPSRAFGDYRYKIKEVDGKPLSDLPEVAKLYFRREPRDFKTPPYVTAEPVITSAKIGENTKFMVMGSDGLFELLTNEEIASLVIRWMDKNMNLAPVKAEPGKLPKVIDVSEDKEAQRPAFRYKDNNSSSPSGSNPEYLIEDKNVATHLIRNALSAGGRKEYVSALVSIPSPMSRRYRDDLTVTVAFFGDSGTPSIVSNATSIVMNPEATTKPKPRL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MSPLTRTVAIKK ---CCCCHHHHHHHH | 22369663 | ||
| 7 | Phosphorylation | -MSPLTRTVAIKKTV -CCCCHHHHHHHHHH | 22369663 | ||
| 92 | Phosphorylation | TINGIKDYSTNTSGN CCCCCCCCCCCCCCC | 23607784 | ||
| 93 | Phosphorylation | INGIKDYSTNTSGNI CCCCCCCCCCCCCCC | 23607784 | ||
| 94 | Phosphorylation | NGIKDYSTNTSGNIN CCCCCCCCCCCCCCC | 23607784 | ||
| 96 | Phosphorylation | IKDYSTNTSGNINMP CCCCCCCCCCCCCCC | 23607784 | ||
| 97 | Phosphorylation | KDYSTNTSGNINMPS CCCCCCCCCCCCCCC | 23607784 | ||
| 104 | Phosphorylation | SGNINMPSPNPKGTE CCCCCCCCCCCCCCC | 23607784 | ||
| 110 | Phosphorylation | PSPNPKGTETQKSQR CCCCCCCCCCHHHHC | 23607784 | ||
| 112 | Phosphorylation | PNPKGTETQKSQRSQ CCCCCCCCHHHHCCC | 23607784 | ||
| 370 | Acetylation | GDYRYKIKEVDGKPL CCEEEEEEEECCCCH | 24489116 | ||
| 469 | Acetylation | VIDVSEDKEAQRPAF EEECCCCHHHCCCCC | 24489116 | ||
| 484 | Phosphorylation | RYKDNNSSSPSGSNP CCCCCCCCCCCCCCC | 27214570 | ||
| 485 | Phosphorylation | YKDNNSSSPSGSNPE CCCCCCCCCCCCCCH | 27214570 | ||
| 487 | Phosphorylation | DNNSSSPSGSNPEYL CCCCCCCCCCCCHHE | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PDP1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PDP1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PDP1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
