| UniProt ID | ERG5_YEAST | |
|---|---|---|
| UniProt AC | P54781 | |
| Protein Name | Cytochrome P450 61 {ECO:0000303|PubMed:8543054} | |
| Gene Name | ERG5 {ECO:0000303|PubMed:8635732} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 538 | |
| Subcellular Localization | ||
| Protein Description | Required to form the C-22(23) double bond in the sterol side chain.. | |
| Protein Sequence | MSSVAENIIQHATHNSTLHQLAKDQPSVGVTTAFSILDTLKSMSYLKIFATLICILLVWDQVAYQIKKGSIAGPKFKFWPIIGPFLESLDPKFEEYKAKWASGPLSCVSIFHKFVVIASTRDLARKILQSSKFVKPCVVDVAVKILRPCNWVFLDGKAHTDYRKSLNGLFTKQALAQYLPSLEQIMDKYMDKFVRLSKENNYEPQVFFHEMREILCALSLNSFCGNYITEDQVRKIADDYYLVTAALELVNFPIIIPYTKTWYGKKTADMAMKIFENCAQMAKDHIAAGGKPVCVMDAWCKLMHDAKNSNDDDSRIYHREFTNKEISEAVFTFLFASQDASSSLACWLFQIVADRPDVLAKIREEQLAVRNNDMSTELNLDLIEKMKYTNMVIKETLRYRPPVLMVPYVVKKNFPVSPNYTAPKGAMLIPTLYPALHDPEVYENPDEFIPERWVEGSKASEAKKNWLVFGCGPHVCLGQTYVMITFAALLGKFALYTDFHHTVTPLSEKIKVFATIFPKDDLLLTFKKRDPITGEVFE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 23 | Ubiquitination | STLHQLAKDQPSVGV HHHHHHHCCCCCCCH | 66.54 | 17644757 | |
| 41 | Ubiquitination | FSILDTLKSMSYLKI HHHHHHHHHHCHHHH | 46.32 | 17644757 | |
| 96 | Phosphorylation | LDPKFEEYKAKWASG HCHHHHHHHHHHHCC | 14.73 | 25005228 | |
| 97 | Ubiquitination | DPKFEEYKAKWASGP CHHHHHHHHHHHCCC | 46.93 | 23749301 | |
| 99 | Ubiquitination | KFEEYKAKWASGPLS HHHHHHHHHHCCCHH | 38.86 | 17644757 | |
| 109 | Phosphorylation | SGPLSCVSIFHKFVV CCCHHHHHHHHHHHH | 24.70 | 25005228 | |
| 113 | Ubiquitination | SCVSIFHKFVVIAST HHHHHHHHHHHHCCH | 29.16 | 23749301 | |
| 126 | Ubiquitination | STRDLARKILQSSKF CHHHHHHHHHHCCCC | 42.01 | 23749301 | |
| 132 | Ubiquitination | RKILQSSKFVKPCVV HHHHHCCCCCCCHHH | 60.46 | 22817900 | |
| 135 | Ubiquitination | LQSSKFVKPCVVDVA HHCCCCCCCHHHHHH | 35.51 | 24961812 | |
| 144 | Ubiquitination | CVVDVAVKILRPCNW HHHHHHHHHHCCCCE | 26.70 | 17644757 | |
| 157 | Ubiquitination | NWVFLDGKAHTDYRK CEEEECCCCCCCHHH | 36.34 | 17644757 | |
| 164 | Ubiquitination | KAHTDYRKSLNGLFT CCCCCHHHHHHCCCH | 53.73 | 17644757 | |
| 172 | Ubiquitination | SLNGLFTKQALAQYL HHHCCCHHHHHHHHC | 26.66 | 17644757 | |
| 188 | Ubiquitination | SLEQIMDKYMDKFVR CHHHHHHHHHHHHHH | 25.70 | 22817900 | |
| 192 | Ubiquitination | IMDKYMDKFVRLSKE HHHHHHHHHHHHHHH | 29.27 | 23749301 | |
| 198 | Ubiquitination | DKFVRLSKENNYEPQ HHHHHHHHHCCCCCC | 69.88 | 23749301 | |
| 235 | Ubiquitination | ITEDQVRKIADDYYL CCHHHHHHHHHHHHH | 43.31 | 17644757 | |
| 241 | Phosphorylation | RKIADDYYLVTAALE HHHHHHHHHHHHHHH | 11.16 | 28132839 | |
| 258 | Phosphorylation | NFPIIIPYTKTWYGK CCCEEECCCCCCCCH | 15.51 | 28132839 | |
| 260 | Ubiquitination | PIIIPYTKTWYGKKT CEEECCCCCCCCHHH | 31.08 | 17644757 | |
| 266 | Ubiquitination | TKTWYGKKTADMAMK CCCCCCHHHHHHHHH | 44.58 | 23749301 | |
| 273 | Ubiquitination | KTADMAMKIFENCAQ HHHHHHHHHHHHHHH | 34.40 | 23749301 | |
| 283 | Ubiquitination | ENCAQMAKDHIAAGG HHHHHHHHHHHHCCC | 44.49 | 23749301 | |
| 291 | Ubiquitination | DHIAAGGKPVCVMDA HHHHCCCCCEEEEHH | 33.10 | 23749301 | |
| 301 | Ubiquitination | CVMDAWCKLMHDAKN EEEHHHHHHHHHHCC | 37.84 | 23749301 | |
| 307 | Ubiquitination | CKLMHDAKNSNDDDS HHHHHHHCCCCCCCC | 67.95 | 23749301 | |
| 324 | Ubiquitination | YHREFTNKEISEAVF HHHHHCHHHHHHHHH | 54.06 | 17644757 | |
| 361 | Ubiquitination | DRPDVLAKIREEQLA CCHHHHHHHHHHHHH | 37.83 | 17644757 | |
| 385 | Ubiquitination | LNLDLIEKMKYTNMV HCHHHHHHHHHHCHH | 33.43 | 23749301 | |
| 387 | Ubiquitination | LDLIEKMKYTNMVIK HHHHHHHHHHCHHHH | 61.05 | 23749301 | |
| 394 | Ubiquitination | KYTNMVIKETLRYRP HHHCHHHHHHHHCCC | 32.98 | 24961812 | |
| 394 | Acetylation | KYTNMVIKETLRYRP HHHCHHHHHHHHCCC | 32.98 | 24489116 | |
| 411 | Ubiquitination | LMVPYVVKKNFPVSP EEEEEEECCCCCCCC | 31.77 | 17644757 | |
| 411 | Acetylation | LMVPYVVKKNFPVSP EEEEEEECCCCCCCC | 31.77 | 24489116 | |
| 412 | Ubiquitination | MVPYVVKKNFPVSPN EEEEEECCCCCCCCC | 52.81 | 23749301 | |
| 417 | Phosphorylation | VKKNFPVSPNYTAPK ECCCCCCCCCCCCCC | 13.99 | 28152593 | |
| 421 | Phosphorylation | FPVSPNYTAPKGAML CCCCCCCCCCCCCCC | 43.02 | 24961812 | |
| 424 | Ubiquitination | SPNYTAPKGAMLIPT CCCCCCCCCCCCCCC | 57.76 | 17644757 | |
| 458 | Ubiquitination | ERWVEGSKASEAKKN HHHCCCCCCCHHHHC | 67.78 | 23749301 | |
| 492 | Ubiquitination | TFAALLGKFALYTDF HHHHHHHHHHHHCCC | 27.68 | 17644757 | |
| 509 | Ubiquitination | TVTPLSEKIKVFATI CCCCHHHHHEEEEEE | 44.44 | 17644757 | |
| 511 | Ubiquitination | TPLSEKIKVFATIFP CCHHHHHEEEEEEEC | 42.22 | 17644757 | |
| 519 | Ubiquitination | VFATIFPKDDLLLTF EEEEEECCCCEEEEE | 53.80 | 23749301 | |
| 527 | Ubiquitination | DDLLLTFKKRDPITG CCEEEEECCCCCCCC | 41.48 | 17644757 | |
| 528 | Ubiquitination | DLLLTFKKRDPITGE CEEEEECCCCCCCCC | 58.82 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ERG5_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ERG5_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ERG5_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Ubiquitylation | |
| Reference | PubMed |
| "A proteomics approach to understanding protein ubiquitination."; Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.; Nat. Biotechnol. 21:921-926(2003). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-164 AND LYS-198, AND MASSSPECTROMETRY. | |
