VPS75_YEAST - dbPTM
VPS75_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VPS75_YEAST
UniProt AC P53853
Protein Name Vacuolar protein sorting-associated protein 75
Gene Name VPS75
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 264
Subcellular Localization Nucleus .
Protein Description Histone chaperone which acts as a cofactor stimulating the histone H3 'Lys-56' acetylation by RTT109. May be involved in vacuolar proteins sorting..
Protein Sequence MMSDQENENEHAKAFLGLAKCEEEVDAIEREVELYRLNKMKPVYEKRDAYIDEIAEFWKIVLSQHVSFANYIRASDFKYIDTIDKIKVEWLALESEMYDTRDFSITFHFHGIEGDFKEQQVTKVFQIKKGKDDQEDGILTSEPVPIEWPQSYDSINPDLIKDKRSPEGKKKYRQGMKTIFGWFRWTGLKPGKEFPHGDSLASLFSEEIYPFCVKYYAEAQRDLEDEEGESGLSADGDSEDDDGSLGEVDLPLSDEEPSSKKRKV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MMSDQENENE
-----CCCCCCCHHH		34.5422369663
78AcetylationYIRASDFKYIDTIDK
HHHHHHCCCCCCCCE		46.4124489116
177AcetylationKKYRQGMKTIFGWFR
HHHHHHHHHHHHHHH		45.3424489116
253PhosphorylationGEVDLPLSDEEPSSK
CEEECCCCCCCCCCC		40.8227214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VPS75_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VPS75_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VPS75_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZRT1_YEASTZRT1genetic
17314980
JHD2_YEASTJHD2genetic
17314980
EAF5_YEASTEAF5genetic
17314980
MED5_YEASTNUT1genetic
17314980
SGF73_YEASTSGF73genetic
17314980
IOC4_YEASTIOC4genetic
17314980
RPB1_YEASTRPO21genetic
17314980
RPC7_YEASTRPC31genetic
17314980
TFS2_YEASTDST1genetic
17314980
BMH1_YEASTBMH1genetic
17314980
RAP1_YEASTRAP1genetic
17314980
RSC1_YEASTRSC1genetic
17314980
RPN13_YEASTRPN13genetic
17314980
VPS64_YEASTVPS64genetic
17314980
TF3B_YEASTBRF1genetic
17314980
LSM6_YEASTLSM6genetic
17314980
HOS4_YEASTHOS4genetic
17314980
TOS2_YEASTTOS2genetic
17314980
FKH1_YEASTFKH1genetic
17314980
VID22_YEASTVID22genetic
17314980
UBP3_YEASTUBP3genetic
17314980
PAT1_YEASTPAT1genetic
17314980
DEP1_YEASTDEP1genetic
17314980
DOA1_YEASTDOA1genetic
17314980
ELP6_YEASTELP6genetic
17314980
GCN1_YEASTGCN1genetic
17314980
SAC3_YEASTSAC3genetic
17314980
LSM1_YEASTLSM1genetic
17314980
MED20_YEASTSRB2genetic
17314980
H3_YEASTHHT1physical
17344218
H4_YEASTHHF1physical
17344218
RT109_YEASTRTT109physical
18036332
GCN5_YEASTGCN5genetic
18458063
VPS75_YEASTVPS75physical
18723682
RT109_YEASTRTT109physical
18723682
VPS75_YEASTVPS75physical
19172748
RT109_YEASTRTT109physical
19172748
VPS75_YEASTVPS75physical
19172749
H2A1_YEASTHTA1physical
19172749
H2A2_YEASTHTA2physical
19172749
H2B1_YEASTHTB1physical
19172749
H2B2_YEASTHTB2physical
19172749
H3_YEASTHHT1physical
19172749
RT109_YEASTRTT109physical
19172749
H4_YEASTHHF1physical
19172749
SAN1_YEASTSAN1genetic
19547744
RPD3_YEASTRPD3genetic
19547744
ELP3_YEASTELP3genetic
19547744
RAD52_YEASTRAD52genetic
18036332
KU70_YEASTYKU70genetic
18036332
VPS75_YEASTVPS75physical
21256037
RPB1_YEASTRPO21genetic
19470761
TFS2_YEASTDST1genetic
19470761
RPB1_YEASTRPO21physical
19470761
HAA1_YEASTHAA1genetic
19470761
RT109_YEASTRTT109genetic
21463458
PP2C1_YEASTPTC1genetic
21127252
CHA4_YEASTCHA4genetic
21127252
RTG3_YEASTRTG3genetic
21127252
KCS1_YEASTKCS1genetic
21127252
VPS75_YEASTVPS75physical
21454705
RT109_YEASTRTT109physical
21454705
RT109_YEASTRTT109physical
23457193
VPS75_YEASTVPS75physical
24688059
VPS75_YEASTVPS75physical
27036862
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VPS75_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3 AND SER-253, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3, AND MASSSPECTROMETRY.

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