HAA1_YEAST - dbPTM
HAA1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HAA1_YEAST
UniProt AC Q12753
Protein Name Transcriptional activator HAA1
Gene Name HAA1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 694
Subcellular Localization Nucleus .
Protein Description Regulates the transcription of a set of genes, many of which encode membrane proteins. Among the genes regulated are YGR138C and YRO2. Does not seem to be dependent on copper..
Protein Sequence MVLINGIKYACERCIRGHRVTTCNHTDQPLMMIKPKGRPSTTCDYCKQLRKNKNANPEGVCTCGRLEKKKLAQKAKEEARAKAKEKQRKQCTCGTDEVCKYHAQKRHLRKSPSSSQKKGRSISRSQPMFERVLSSTSLDSNMLSGHGALSDTSSILTSTFLDSEPGVGKISKDYHHVPSLASISSLQSSQSLDQNFSIPQSPPLSSMSFNFLTGNINETNQNHSNHQHSKSGNNWQDSSVSLPAKADSRLNMMDKNNSVGLDLLGHSKRISPISNSRVGEVSVPLEEYIPSDIDGVGRVTDKSSLVYDWPFDESIERNFSTTATAATGESKFDINDNCNRINSKSYSKTNSMNGNGMNNSNNNNINSNGNDKNNNNSSRQEHQGNGLFDMFTDSSSISTLSRANLLLQEKIGSQENSVKQENYSKNPQLRHQLTSRSRSFIHHPANEYLKNTFGNSHSNDIGKGVEVLSLTPSFMDIPEKERETERSPSSNYITDRPFTRKPRSSSIDVNHRYPPMAPTTVATSPGALNNAVASNLDDQLSLTSLNSQPSSIANMMMDPSNLAEQSSIHSVPQSINSPRMPKTGSRQDKNIHTKKEERNPLNNIHDLSQLENVPDEMNQMFSPPLKSMNRPDAIRENSSSSNFIIQGNSMISTPSGRNDLPDTSPMSSIQTASPPSQLLTDQGFADLDNFMSSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
40PhosphorylationIKPKGRPSTTCDYCK
ECCCCCCCCCHHHHH		34.6821551504
41PhosphorylationKPKGRPSTTCDYCKQ
CCCCCCCCCHHHHHH		33.8427214570
62PhosphorylationANPEGVCTCGRLEKK
CCCCCCCCHHHHHHH		18.6527017623
92PhosphorylationEKQRKQCTCGTDEVC
HHHHHHCCCCHHHHH		16.1019779198
111PhosphorylationQKRHLRKSPSSSQKK
HHHHHHCCCCHHHHH		24.4728889911
113PhosphorylationRHLRKSPSSSQKKGR
HHHHCCCCHHHHHCC		50.1127214570
125PhosphorylationKGRSISRSQPMFERV
HCCCCCCCHHHHHHH		31.6721440633
134PhosphorylationPMFERVLSSTSLDSN
HHHHHHHHCCCCCCC		28.8128889911
136PhosphorylationFERVLSSTSLDSNML
HHHHHHCCCCCCCCC		29.9021440633
137PhosphorylationERVLSSTSLDSNMLS
HHHHHCCCCCCCCCC		31.9328889911
150PhosphorylationLSGHGALSDTSSILT
CCCCCCCCCHHHHHH		38.0021440633
163PhosphorylationLTSTFLDSEPGVGKI
HHHHHCCCCCCCCCC		48.0827214570
231PhosphorylationSNHQHSKSGNNWQDS
CCCCCCCCCCCCCCC		50.1722369663
238PhosphorylationSGNNWQDSSVSLPAK
CCCCCCCCCCCCCCC		19.9622369663
239PhosphorylationGNNWQDSSVSLPAKA
CCCCCCCCCCCCCCC		24.8222369663
241PhosphorylationNWQDSSVSLPAKADS
CCCCCCCCCCCCCCH		30.5022369663
248PhosphorylationSLPAKADSRLNMMDK
CCCCCCCHHCCCCCC		43.4522369663
258PhosphorylationNMMDKNNSVGLDLLG
CCCCCCCCCCHHHCC		27.2722369663
267PhosphorylationGLDLLGHSKRISPIS
CHHHCCCCCCCCCCC		23.1029688323
271PhosphorylationLGHSKRISPISNSRV
CCCCCCCCCCCCCCC		21.8822369663
274PhosphorylationSKRISPISNSRVGEV
CCCCCCCCCCCCCEE		31.9422369663
276PhosphorylationRISPISNSRVGEVSV
CCCCCCCCCCCEEEE		22.8822369663
282PhosphorylationNSRVGEVSVPLEEYI
CCCCCEEEEEHHHHC		17.4520377248
291PhosphorylationPLEEYIPSDIDGVGR
EHHHHCCCCCCCCCC		37.3328889911
300PhosphorylationIDGVGRVTDKSSLVY
CCCCCCCCCCCCEEE		36.0327017623
303PhosphorylationVGRVTDKSSLVYDWP
CCCCCCCCCEEEECC		31.5427017623
304PhosphorylationGRVTDKSSLVYDWPF
CCCCCCCCEEEECCC		27.8230377154
314PhosphorylationYDWPFDESIERNFST
EECCCCHHHHHHCCC		31.4327017623
320PhosphorylationESIERNFSTTATAAT
HHHHHHCCCCCCCCC		28.5322369663
321PhosphorylationSIERNFSTTATAATG
HHHHHCCCCCCCCCC		19.1322369663
322PhosphorylationIERNFSTTATAATGE
HHHHCCCCCCCCCCC		22.3222369663
324PhosphorylationRNFSTTATAATGESK
HHCCCCCCCCCCCCC		18.0922369663
327PhosphorylationSTTATAATGESKFDI
CCCCCCCCCCCCCCC		38.7322369663
330PhosphorylationATAATGESKFDINDN
CCCCCCCCCCCCCCC		39.7122369663
343PhosphorylationDNCNRINSKSYSKTN
CCCCCCCCCCCCCCC		22.1721551504
345PhosphorylationCNRINSKSYSKTNSM
CCCCCCCCCCCCCCC		34.1627017623
349PhosphorylationNSKSYSKTNSMNGNG
CCCCCCCCCCCCCCC		26.9522369663
351PhosphorylationKSYSKTNSMNGNGMN
CCCCCCCCCCCCCCC		20.8921440633
360PhosphorylationNGNGMNNSNNNNINS
CCCCCCCCCCCCCCC		35.6122369663
367PhosphorylationSNNNNINSNGNDKNN
CCCCCCCCCCCCCCC		42.1722369663
392PhosphorylationNGLFDMFTDSSSIST
CCHHHHCCCHHHHHH		28.4722369663
394PhosphorylationLFDMFTDSSSISTLS
HHHHCCCHHHHHHHH		23.9522369663
395PhosphorylationFDMFTDSSSISTLSR
HHHCCCHHHHHHHHH		34.2022369663
396PhosphorylationDMFTDSSSISTLSRA
HHCCCHHHHHHHHHH		25.2222369663
398PhosphorylationFTDSSSISTLSRANL
CCCHHHHHHHHHHHH		25.8322369663
399PhosphorylationTDSSSISTLSRANLL
CCHHHHHHHHHHHHH		27.3822369663
401PhosphorylationSSSISTLSRANLLLQ
HHHHHHHHHHHHHHH		29.4522369663
413PhosphorylationLLQEKIGSQENSVKQ
HHHHHHCCCCCCCCH		37.4822369663
417PhosphorylationKIGSQENSVKQENYS
HHCCCCCCCCHHHHC		29.9122369663
434PhosphorylationPQLRHQLTSRSRSFI
HHHHHHHHHCCHHHH		18.6124961812
435PhosphorylationQLRHQLTSRSRSFIH
HHHHHHHHCCHHHHC		36.5324961812
437PhosphorylationRHQLTSRSRSFIHHP
HHHHHHCCHHHHCCC		31.8522369663
439PhosphorylationQLTSRSRSFIHHPAN
HHHHCCHHHHCCCHH		29.7822369663
448PhosphorylationIHHPANEYLKNTFGN
HCCCHHHHHHHHCCC		23.8422369663
452PhosphorylationANEYLKNTFGNSHSN
HHHHHHHHCCCCCCC		31.1922369663
456PhosphorylationLKNTFGNSHSNDIGK
HHHHCCCCCCCCCCC		28.7722369663
458PhosphorylationNTFGNSHSNDIGKGV
HHCCCCCCCCCCCCC		35.7021440633
473PhosphorylationEVLSLTPSFMDIPEK
EEEEECHHHHCCCHH		28.1521440633
484PhosphorylationIPEKERETERSPSSN
CCHHHHCCCCCCCCC		42.8129136822
487PhosphorylationKERETERSPSSNYIT
HHHCCCCCCCCCCCC		23.9322369663
489PhosphorylationRETERSPSSNYITDR
HCCCCCCCCCCCCCC		32.2522369663
490PhosphorylationETERSPSSNYITDRP
CCCCCCCCCCCCCCC		36.7222369663
492PhosphorylationERSPSSNYITDRPFT
CCCCCCCCCCCCCCC		13.7222369663
494PhosphorylationSPSSNYITDRPFTRK
CCCCCCCCCCCCCCC		18.6529734811
499PhosphorylationYITDRPFTRKPRSSS
CCCCCCCCCCCCCCC		40.2322369663
504PhosphorylationPFTRKPRSSSIDVNH
CCCCCCCCCCCCCCC		36.6425005228
505PhosphorylationFTRKPRSSSIDVNHR
CCCCCCCCCCCCCCC		32.3728889911
506PhosphorylationTRKPRSSSIDVNHRY
CCCCCCCCCCCCCCC		24.8525533186
566PhosphorylationPSNLAEQSSIHSVPQ
HHHHHHHCCCCCCCC		23.8228889911
570PhosphorylationAEQSSIHSVPQSINS
HHHCCCCCCCCCCCC		33.5528889911
608PhosphorylationLNNIHDLSQLENVPD
CCCCCCHHHHHCCCH		38.4819779198
622PhosphorylationDEMNQMFSPPLKSMN
HHHHHHCCCCCHHCC		21.9228889911
638PhosphorylationPDAIRENSSSSNFII
CHHHHHCCCCCCEEE		27.1827017623
641PhosphorylationIRENSSSSNFIIQGN
HHHCCCCCCEEEECC		37.3927017623
649PhosphorylationNFIIQGNSMISTPSG
CEEEECCCCEECCCC		25.0727017623
652PhosphorylationIQGNSMISTPSGRND
EECCCCEECCCCCCC		26.1427017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HAA1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HAA1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HAA1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
H2A2_YEASTHTA2physical
16554755
NGG1_YEASTNGG1physical
16554755
TFS2_YEASTDST1physical
16554755
ERB1_YEASTERB1physical
16554755
TBP7_YEASTYTA7genetic
19547744
URE2_YEASTURE2genetic
20959818
SEF1_YEASTSEF1genetic
20959818
GLN3_YEASTGLN3genetic
20959818
UME6_YEASTUME6genetic
21127252
PLM2_YEASTPLM2genetic
21127252
PHD1_YEASTPHD1genetic
21127252
RPN4_YEASTRPN4genetic
21127252
ATG1_YEASTATG1genetic
21127252
SWI4_YEASTSWI4genetic
21127252
IXR1_YEASTIXR1genetic
21127252
SSN3_YEASTSSN3genetic
21127252
PNPP_YEASTPHO13genetic
25282639
SWI6_YEASTSWI6genetic
27708008
GPR1_YEASTGPR1genetic
27708008
ODO2_YEASTKGD2genetic
27708008
NPR3_YEASTNPR3genetic
27708008
SNF6_YEASTSNF6genetic
27708008
BUL2_YEASTBUL2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HAA1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125; SER-134; SER-137;SER-241; SER-248; SER-271; SER-506; SER-566 AND SER-570, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-506, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-437 AND SER-439, ANDMASS SPECTROMETRY.

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