| UniProt ID | RPN4_YEAST | |
|---|---|---|
| UniProt AC | Q03465 | |
| Protein Name | Protein RPN4 | |
| Gene Name | RPN4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 531 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Acts as a transcriptional activator of a number of genes encoding proteasomal subunits. Binds to a PACE (proteasome-associated control element) DNA sequence 5'-GGTGGCAAA-3'. Its expression is in turn regulated by the 26S proteasome, thereby providing a negative feedback control mechanism. Required for normal growth at low temperatures.. | |
| Protein Sequence | MASTELSLKRTLTDILEDELYHTNPGHSQFTSHYQNYHPNASITPYKLVNKNKENNTFTWNHSLQHQNESSAASIPPQQTYHFPIFNKYADPTLTTTTSFTTSEATANDRQINNVHLIPNEIKGASETPLQKTVNLKNIMKVSDPYVPTRNTFNYDVKISNDFFDNGDNLYGNDEEVLFYEDNYNPKMQWSLQDNSAAINNEDARAIFNNEFDSDDDDISDDEEDEIEENCLQQEQHQEEPLLSLDVTPISMFGSDQKTGRAKSSSHLFNEYSYVDSNMDSISSVVSEDLLDERGHEKIEDEDEDNDLDEDDIYDISLLKNRRKQSFVLNKNTIDFERFPSPSTSANVPSTATTGKRKPAKSSSNRSCVSNSNENGTLERIKKPTSAVVSSNASRRKLINYTKKHLSSHSSTNSNSKPSTASPSAHTSSSDGNNEIFTCQIMNLITNEPCGAQFSRSYDLTRHQNTIHAKRKIVFRCSECIKILGSEGYQKTFSRLDALTRHIKSKHEDLSLEQRQEVTKFAKANIGYVMG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 126 | Phosphorylation | PNEIKGASETPLQKT CCCCCCCCCCCCCCE | 51.15 | 22890988 | |
| 128 | Phosphorylation | EIKGASETPLQKTVN CCCCCCCCCCCCEEC | 27.14 | 22890988 | |
| 133 | Phosphorylation | SETPLQKTVNLKNIM CCCCCCCEECHHHHE | 11.15 | 22890988 | |
| 214 | Phosphorylation | IFNNEFDSDDDDISD HHCCCCCCCCCCCCC | 48.54 | 17532487 | |
| 220 | Phosphorylation | DSDDDDISDDEEDEI CCCCCCCCCCCHHHH | 46.10 | 28889911 | |
| 326 | Phosphorylation | LKNRRKQSFVLNKNT HHCCCCCCEECCCCC | 21.98 | 28889911 | |
| 341 | Phosphorylation | IDFERFPSPSTSANV CCCCCCCCCCCCCCC | 28.86 | 23749301 | |
| 343 | Phosphorylation | FERFPSPSTSANVPS CCCCCCCCCCCCCCC | 39.05 | 27017623 | |
| 350 | Phosphorylation | STSANVPSTATTGKR CCCCCCCCCCCCCCC | 26.79 | 27017623 | |
| 353 | Phosphorylation | ANVPSTATTGKRKPA CCCCCCCCCCCCCCC | 35.85 | 27017623 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RPN4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RPN4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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