| UniProt ID | EUG1_YEAST | |
|---|---|---|
| UniProt AC | P32474 | |
| Protein Name | Protein disulfide-isomerase EUG1 | |
| Gene Name | EUG1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 517 | |
| Subcellular Localization | Endoplasmic reticulum lumen. | |
| Protein Description | Probably interacts with nascent polypeptides in the endoplasmic reticulum. It is an essential gene only in the absence of PDI. Its native disulfide isomerase activity is very low.. | |
| Protein Sequence | MQVTTRFISAIVSFCLFASFTLAENSARATPGSDLLVLTEKKFKSFIESHPLVLVEFFAPWCLHSQILRPHLEEAASILKEHNVPVVQIDCEANSMVCLQQTINTYPTLKIFKNGRIFDGQVYRGVKITDEITQYMIQLYEASVIYLNSEDEIQPYLENATLPVVINRGLTGLNETYQEVALDLAEDYVFLSLLDSEDKSLSIHLPNTTEPILFDGNVDSLVGNSVALTQWLKVVILPYFTDIEPDLFPKYISSNLPLAYFFYTSEEELEDYTDLFTQLGKENRGQINFIALNSTMFPHHVRFLNMREQFPLFAIHNMINNLKYGLPQLPEEEYAKLEKPQPLDRDMIVQLVKDYREGTAKPIVKSEEIPKEQKSNVYKIVGKTHDDIVHDDDKDVLVKYYATWCIHSKRFAPIYEEIANVLASDESVRDKILIAEVDSGANDILSFPVTGYPTIALYPAGNNSKPIIFNKIRNLEDVFEFIKESGTHHIDGQAIYDKLHQAKDSEVSTEDTVHDEL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 41 | Acetylation | DLLVLTEKKFKSFIE CEEEEEHHHHHHHHH | 59.27 | 24489116 | |
| 159 | N-linked_Glycosylation | EIQPYLENATLPVVI CCHHHHHCCCCCEEE | 35.31 | - | |
| 174 | N-linked_Glycosylation | NRGLTGLNETYQEVA CCCCCCCCHHHHHHH | 40.69 | - | |
| 207 | N-linked_Glycosylation | SLSIHLPNTTEPILF CEEEECCCCCCCEEC | 67.02 | - | |
| 293 | N-linked_Glycosylation | QINFIALNSTMFPHH CEEEEEECCCCCHHH | 26.81 | - | |
| 394 | Acetylation | DIVHDDDKDVLVKYY HCCCCCCHHHHHHHH | 57.65 | 24489116 | |
| 424 | Phosphorylation | EIANVLASDESVRDK HHHHHHCCCHHHHCC | 37.44 | 19684113 | |
| 462 | N-linked_Glycosylation | IALYPAGNNSKPIIF EEEEECCCCCCCCEE | 52.27 | - | |
| 498 | Acetylation | DGQAIYDKLHQAKDS CCHHHHHHHHHHCCC | 30.78 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EUG1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EUG1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EUG1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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