| UniProt ID | PDK2_YEAST | |
|---|---|---|
| UniProt AC | P53170 | |
| Protein Name | [Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial | |
| Gene Name | PKP2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 491 | |
| Subcellular Localization | Mitochondrion matrix . | |
| Protein Description | Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit (PDA1), thus contributing to the regulation of glucose metabolism.. | |
| Protein Sequence | MSKYQINCIRYRHFLRTSNISQIPDFTKYCIGPVNEELAPYIMETMKAYPSNSEYINPQHYYHNRTVLVENYLKRSPNPVSLTQLAQYYDDSTKLTRTKIINSGKFVKEELVIRIAHKLNQLQQLPFNVVNNFHFVQVYESYYNIFESFRKYPTIRTLEDASQFADFIKNMLEGFNTLNLPHLIMGALECTILDLYPREKMDQLLSDLLRARISRRLIVEEHVSITANYTSGKEENTLVLGDIFQECSAKKYLLEASEESQKFIQDMYFKDIPMPEFIIEGDTQLSFYFLPTHLKYLLGEILRNTYEATMKHYIRKGLEKPEPIIVTVVSNDESYLFRISDKAGGVLHDDENLWSFGKSKERAQESLNNFHKLPGLQTVSIYDEVHSHTKYNSKLKSLQSITLKPYMHTSLEPMSYPSIINGHIKYETPLIELLKRSFRYKLGIGLAMCKVYAEYWNGDLSLHSMPGYGTDVVLKLGNLMKHTKKLQLDKV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSKYQINCI ------CCCHHHHHH | 24909858 | ||
| 252 | Phosphorylation | QECSAKKYLLEASEE HHCCHHHHHHHHCHH | 28889911 | ||
| 327 | Phosphorylation | KPEPIIVTVVSNDES CCCCEEEEEEECCCE | 19795423 | ||
| 330 | Phosphorylation | PIIVTVVSNDESYLF CEEEEEEECCCEEEE | 19795423 | ||
| 334 | Phosphorylation | TVVSNDESYLFRISD EEEECCCEEEEEEEC | 19795423 | ||
| 335 | Phosphorylation | VVSNDESYLFRISDK EEECCCEEEEEEECC | 19795423 | ||
| 340 | Phosphorylation | ESYLFRISDKAGGVL CEEEEEEECCCCCEE | 19795423 | ||
| 355 | Phosphorylation | HDDENLWSFGKSKER ECCCCHHHCCCCHHH | 19795423 | ||
| 406 | Phosphorylation | QSITLKPYMHTSLEP CCCCCCCCCCCCCCC | 29650682 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PDK2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PDK2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PDK2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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