MSN4_YEAST - dbPTM
MSN4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MSN4_YEAST
UniProt AC P33749
Protein Name Zinc finger protein MSN4
Gene Name MSN4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 630
Subcellular Localization Cytoplasm. Nucleus.
Protein Description Positive transcriptional factor that acts as a component of the stress responsive system. Recognizes and binds to the stress response element (STRE) which is involved in the response to various forms of stress (heat, oxidative, osmotic, etc.). Involved in the regulation of the CTT1, DDR2, HSP12 genes..
Protein Sequence MLVFGPNSSFVRHANKKQEDSSIMNEPNGLMDPVLSTTNVSATSSNDNSANNSISSPEYTFGQFSMDSPHRTDATNTPILTATTNTTANNSLMNLKDTASLATNWKWKNSNNAQFVNDGEKQSSNANGKKNGGDKIYSSVATPQALNDELKNLEQLEKVFSPMNPINDSHFNENIELSPHQHATSPKTNLLEAEPSIYSNLFLDARLPNNANSTTGLNDNDYNLDDTNNDNTNSMQSILEDFVSSEEALKFMPDAGRDARRYSEVVTSSFPSMTDSRNSISHSIEFWNLNHKNSSNSKPTQQIIPEGTATTERRGSTISPTTTINNSNPNFKLLDHDVSQALSGYSMDFSKDSGITKPKSISSSLNRISHSSSTTRQQRASLPLIHDIESFANDSVMANPLSDSASFLSEENEDDAFGALNYNSLDATTMSAFDNNVDPFNILKSSPAQDQQFIKPSMMLSDNASAAAKLATSGVDNITPTPAFQRRSYDISMNSSFKILPTSQAHHAAQHHQQQPTKQATVSPNTRRRKSSSVTLSPTISHNNNNGKVPVQPRKRKSITTIDPNNYDKNKPFKCKDCEKAFRRSEHLKRHIRSVHSTERPFACMFCEKKFSRSDNLSQHLKTHKKHGDF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MLVFGPNS
-------CCEECCCH		6.9422814378
8PhosphorylationMLVFGPNSSFVRHAN
CCEECCCHHHHHCCC		28.4328152593
9PhosphorylationLVFGPNSSFVRHANK
CEECCCHHHHHCCCC		34.1119795423
21PhosphorylationANKKQEDSSIMNEPN
CCCCCCCCCCCCCCC		22.4719795423
22PhosphorylationNKKQEDSSIMNEPNG
CCCCCCCCCCCCCCC		37.8719795423
72PhosphorylationSMDSPHRTDATNTPI
CCCCCCCCCCCCCCE		27.2728889911
75PhosphorylationSPHRTDATNTPILTA
CCCCCCCCCCCEEEE		42.3027017623
77PhosphorylationHRTDATNTPILTATT
CCCCCCCCCEEEEEC		13.8327017623
81PhosphorylationATNTPILTATTNTTA
CCCCCEEEEECCCCC		23.7627017623
83PhosphorylationNTPILTATTNTTANN
CCCEEEEECCCCCCC		18.4927017623
84PhosphorylationTPILTATTNTTANNS
CCEEEEECCCCCCCC		28.2719779198
86PhosphorylationILTATTNTTANNSLM
EEEEECCCCCCCCCC		25.7827017623
87PhosphorylationLTATTNTTANNSLMN
EEEECCCCCCCCCCC		29.4727017623
91PhosphorylationTNTTANNSLMNLKDT
CCCCCCCCCCCHHHH		28.8927017623
106AcetylationASLATNWKWKNSNNA
HHHHHCCEEECCCCC		50.8124489116
108UbiquitinationLATNWKWKNSNNAQF
HHHCCEEECCCCCCC		46.9323749301
121UbiquitinationQFVNDGEKQSSNANG
CCCCCCCCCCCCCCC		62.0923749301
135UbiquitinationGKKNGGDKIYSSVAT
CCCCCCCCCHHHCCC		46.9817644757
137PhosphorylationKNGGDKIYSSVATPQ
CCCCCCCHHHCCCHH		10.7124930733
138PhosphorylationNGGDKIYSSVATPQA
CCCCCCHHHCCCHHH		23.0822369663
139PhosphorylationGGDKIYSSVATPQAL
CCCCCHHHCCCHHHH		9.9822369663
142PhosphorylationKIYSSVATPQALNDE
CCHHHCCCHHHHCHH		17.4922369663
151UbiquitinationQALNDELKNLEQLEK
HHHCHHHHCHHHHHH		58.3917644757
158UbiquitinationKNLEQLEKVFSPMNP
HCHHHHHHHHCCCCC		58.1117644757
161PhosphorylationEQLEKVFSPMNPIND
HHHHHHHCCCCCCCC		26.6522369663
169PhosphorylationPMNPINDSHFNENIE
CCCCCCCHHCCCCCC		26.0322369663
178PhosphorylationFNENIELSPHQHATS
CCCCCCCCCCCCCCC		13.9322369663
184PhosphorylationLSPHQHATSPKTNLL
CCCCCCCCCCCCCCC		43.3620377248
185PhosphorylationSPHQHATSPKTNLLE
CCCCCCCCCCCCCCC		25.7822369663
187UbiquitinationHQHATSPKTNLLEAE
CCCCCCCCCCCCCCC		50.2217644757
262PhosphorylationAGRDARRYSEVVTSS
CCCCHHHHHHHHHHC		12.0222369663
263PhosphorylationGRDARRYSEVVTSSF
CCCHHHHHHHHHHCC		23.3122369663
267PhosphorylationRRYSEVVTSSFPSMT
HHHHHHHHHCCCCCC		24.6722369663
268PhosphorylationRYSEVVTSSFPSMTD
HHHHHHHHCCCCCCC		20.5522369663
269PhosphorylationYSEVVTSSFPSMTDS
HHHHHHHCCCCCCCC		31.6322369663
272PhosphorylationVVTSSFPSMTDSRNS
HHHHCCCCCCCCCCC		32.1023749301
274PhosphorylationTSSFPSMTDSRNSIS
HHCCCCCCCCCCCCC		34.8523749301
276PhosphorylationSFPSMTDSRNSISHS
CCCCCCCCCCCCCCE		24.9719779198
279PhosphorylationSMTDSRNSISHSIEF
CCCCCCCCCCCEEEE		25.1028889911
281PhosphorylationTDSRNSISHSIEFWN
CCCCCCCCCEEEEEE		15.8228889911
283PhosphorylationSRNSISHSIEFWNLN
CCCCCCCEEEEEECC		19.6123749301
292UbiquitinationEFWNLNHKNSSNSKP
EEEECCCCCCCCCCC		58.4117644757
294PhosphorylationWNLNHKNSSNSKPTQ
EECCCCCCCCCCCCE		35.3828889911
295PhosphorylationNLNHKNSSNSKPTQQ
ECCCCCCCCCCCCEE		55.2923810556
297PhosphorylationNHKNSSNSKPTQQII
CCCCCCCCCCCEEEC		41.7921551504
298UbiquitinationHKNSSNSKPTQQIIP
CCCCCCCCCCEEECC		57.2323749301
300PhosphorylationNSSNSKPTQQIIPEG
CCCCCCCCEEECCCC		36.5219823750
308PhosphorylationQQIIPEGTATTERRG
EEECCCCCCCCCCCC		21.1121440633
310PhosphorylationIIPEGTATTERRGST
ECCCCCCCCCCCCCE		29.0921440633
311PhosphorylationIPEGTATTERRGSTI
CCCCCCCCCCCCCEE		25.6521440633
316PhosphorylationATTERRGSTISPTTT
CCCCCCCCEECCCCC		22.2822369663
317PhosphorylationTTERRGSTISPTTTI
CCCCCCCEECCCCCC		28.4422369663
319PhosphorylationERRGSTISPTTTINN
CCCCCEECCCCCCCC		19.1122369663
321PhosphorylationRGSTISPTTTINNSN
CCCEECCCCCCCCCC		29.7622369663
322PhosphorylationGSTISPTTTINNSNP
CCEECCCCCCCCCCC		29.1222369663
323PhosphorylationSTISPTTTINNSNPN
CEECCCCCCCCCCCC		24.9622369663
327PhosphorylationPTTTINNSNPNFKLL
CCCCCCCCCCCCEEC		49.5322369663
332UbiquitinationNNSNPNFKLLDHDVS
CCCCCCCEECCCCHH		55.5717644757
351UbiquitinationGYSMDFSKDSGITKP
CCCCCCCCCCCCCCC		56.7717644757
356PhosphorylationFSKDSGITKPKSISS
CCCCCCCCCCCCHHH		44.8321440633
357AcetylationSKDSGITKPKSISSS
CCCCCCCCCCCHHHH		48.8323572591
359UbiquitinationDSGITKPKSISSSLN
CCCCCCCCCHHHHHH		63.0823749301
360PhosphorylationSGITKPKSISSSLNR
CCCCCCCCHHHHHHH		35.9122369663
362PhosphorylationITKPKSISSSLNRIS
CCCCCCHHHHHHHHC		22.4422369663
363PhosphorylationTKPKSISSSLNRISH
CCCCCHHHHHHHHCC		36.8623749301
364PhosphorylationKPKSISSSLNRISHS
CCCCHHHHHHHHCCC		23.9122369663
369PhosphorylationSSSLNRISHSSSTTR
HHHHHHHCCCCCCHH		17.6823749301
371PhosphorylationSLNRISHSSSTTRQQ
HHHHHCCCCCCHHHH		21.1323749301
372PhosphorylationLNRISHSSSTTRQQR
HHHHCCCCCCHHHHH		26.7023749301
373PhosphorylationNRISHSSSTTRQQRA
HHHCCCCCCHHHHHH		36.4923749301
445PhosphorylationDPFNILKSSPAQDQQ
CHHHHHCCCCCCCCC		37.8022369663
446PhosphorylationPFNILKSSPAQDQQF
HHHHHCCCCCCCCCC		23.7522369663
461PhosphorylationIKPSMMLSDNASAAA
CCHHHHHCCCHHHHH		15.7724961812
465PhosphorylationMMLSDNASAAAKLAT
HHHCCCHHHHHHHHH		25.3724961812
469UbiquitinationDNASAAAKLATSGVD
CCHHHHHHHHHCCCC		33.6517644757
472PhosphorylationSAAAKLATSGVDNIT
HHHHHHHHCCCCCCC		36.1329688323
473PhosphorylationAAAKLATSGVDNITP
HHHHHHHCCCCCCCC		31.0823810556
479PhosphorylationTSGVDNITPTPAFQR
HCCCCCCCCCCHHHC		27.6222369663
481PhosphorylationGVDNITPTPAFQRRS
CCCCCCCCCHHHCCC		20.7122369663
488PhosphorylationTPAFQRRSYDISMNS
CCHHHCCCEEECCCC		29.3722369663
489PhosphorylationPAFQRRSYDISMNSS
CHHHCCCEEECCCCC		18.5821440633
492PhosphorylationQRRSYDISMNSSFKI
HCCCEEECCCCCEEE		14.7130377154
493OxidationRRSYDISMNSSFKIL
CCCEEECCCCCEEEC		6.0315665377
495PhosphorylationSYDISMNSSFKILPT
CEEECCCCCEEECCC		28.6330377154
496PhosphorylationYDISMNSSFKILPTS
EEECCCCCEEECCCH		26.0923810556
503PhosphorylationSFKILPTSQAHHAAQ
CEEECCCHHHHHHHH		24.3523749301
521PhosphorylationQQPTKQATVSPNTRR
CCCCCCCCCCCCCCC		21.0123749301
523PhosphorylationPTKQATVSPNTRRRK
CCCCCCCCCCCCCCC		14.2123810556
526PhosphorylationQATVSPNTRRRKSSS
CCCCCCCCCCCCCCC		29.0125005228
531PhosphorylationPNTRRRKSSSVTLSP
CCCCCCCCCCEEECC		26.4922369663
532PhosphorylationNTRRRKSSSVTLSPT
CCCCCCCCCEEECCE		31.6822369663
533PhosphorylationTRRRKSSSVTLSPTI
CCCCCCCCEEECCEE		26.6422369663
535PhosphorylationRRKSSSVTLSPTISH
CCCCCCEEECCEECC		24.3824909858
537PhosphorylationKSSSVTLSPTISHNN
CCCCEEECCEECCCC		15.6122369663
539PhosphorylationSSVTLSPTISHNNNN
CCEEECCEECCCCCC		31.5622369663
541PhosphorylationVTLSPTISHNNNNGK
EEECCEECCCCCCCC		23.7322369663
557AcetylationPVQPRKRKSITTIDP
CCCCCCCCCCEECCC		49.6023572591
558PhosphorylationVQPRKRKSITTIDPN
CCCCCCCCCEECCCC		29.2422369663
560PhosphorylationPRKRKSITTIDPNNY
CCCCCCCEECCCCCC		25.4522890988
561PhosphorylationRKRKSITTIDPNNYD
CCCCCCEECCCCCCC		23.0122890988
567PhosphorylationTTIDPNNYDKNKPFK
EECCCCCCCCCCCCC		34.6322890988
609UbiquitinationFACMFCEKKFSRSDN
EEEEEECCCCCCCCC		61.3717644757
610UbiquitinationACMFCEKKFSRSDNL
EEEEECCCCCCCCCH		26.6917644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MSN4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MSN4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MSN4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RIM15_YEASTRIM15genetic
14741356
CYAA_YEASTCYR1genetic
14745784
MSN2_YEASTMSN2genetic
15922872
PNC1_YEASTPNC1genetic
17914901
EAF7_YEASTEAF7physical
18212056
RIM15_YEASTRIM15genetic
18225956
GIS1_YEASTGIS1genetic
18225956
SCH9_YEASTSCH9genetic
18225956
RAS2_YEASTRAS2genetic
18225956
RTG3_YEASTRTG3genetic
20093466
ARL1_YEASTARL1genetic
20093466
RBSK_YEASTRBK1genetic
20093466
VAM6_YEASTVAM6genetic
20093466
INO2_YEASTINO2genetic
20093466
RPA14_YEASTRPA14genetic
20093466
MNN10_YEASTMNN10genetic
20093466
PT122_YEASTPET122genetic
20093466
OCA2_YEASTOCA2genetic
20093466
VPS21_YEASTVPS21genetic
20093466
HDA3_YEASTHDA3genetic
20093466
YAK1_YEASTYAK1genetic
21149646
SWI5_YEASTSWI5genetic
20831804
SWI6_YEASTSWI6genetic
20831804
MSN2_YEASTMSN2genetic
19470158
KCS1_YEASTKCS1genetic
21127252
GLN3_YEASTGLN3genetic
21127252
XBP1_YEASTXBP1genetic
21127252
INO2_YEASTINO2genetic
21127252
PBS2_YEASTPBS2genetic
21127252
MET18_YEASTMET18genetic
21127252
RAD51_YEASTRAD51genetic
21127252
GIS1_YEASTGIS1genetic
21127252
IXR1_YEASTIXR1genetic
21127252
PUT3_YEASTPUT3genetic
21127252
DCC1_YEASTDCC1genetic
21127252
UPC2_YEASTUPC2genetic
21127252
KAPA_YEASTTPK1genetic
21749328
KAPB_YEASTTPK2genetic
21749328
KAPC_YEASTTPK3genetic
21749328
RAS2_YEASTRAS2genetic
21749328
UMP1_YEASTUMP1genetic
21757539
MSN2_YEASTMSN2genetic
21757539
KAPA_YEASTTPK1genetic
21757539
KAPC_YEASTTPK3genetic
21757539
PSR1_YEASTPSR1genetic
21757539
PSR2_YEASTPSR2genetic
21757539
WHI2_YEASTWHI2genetic
21757539
GIS1_YEASTGIS1genetic
23171550
GIS1_YEASTGIS1genetic
24516402
CSG2_YEASTCSG2genetic
27708008
SGF29_YEASTSGF29genetic
27708008
VAM6_YEASTVAM6genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
RAS2_YEASTRAS2genetic
27708008
WHI2_YEASTWHI2genetic
26862728
CSK21_YEASTCKA1genetic
28330760
CSK22_YEASTCKA2genetic
28330760
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MSN4_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-142; SER-319; THR-479;TYR-489 AND SER-558, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-446, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-558, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263; SER-319 ANDSER-558, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316; SER-319; SER-488AND SER-558, AND MASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory