| UniProt ID | GLN3_YEAST | |
|---|---|---|
| UniProt AC | P18494 | |
| Protein Name | Nitrogen regulatory protein GLN3 | |
| Gene Name | GLN3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 730 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Positive nitrogen regulatory protein. Required for the activation of transcription of a number of genes (including the allantoin pathway genes) in response to the replacement of glutamine by glutamate as source of nitrogen. Binds the nitrogen upstream activation sequence of GLN1, the gene encoding glutamine synthetase. URE2 may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine.. | |
| Protein Sequence | MQDDPENSKLYDLLNSHLDVHGRSNEEPRQTGDSRSQSSGNTGENEEDIAFASGLNGGTFDSMLEALPDDLYFTDFVSPFTAAATTSVTTKTVKDTTPATNHMDDDIAMFDSLATTQPIDIAASNQQNGEIAQLWDFNVDQFNMTPSNSSGSATISAPNSFTSDIPQYNHGSLGNSVSKSSLFPYNSSTSNSNINQPSINNNSNTNAQSHHSFNIYKLQNNNSSSSAMNITNNNNSNNSNIQHPFLKKSDSIGLSSSNTTNSVRKNSLIKPMSSTSLANFKRAASVSSSISNMEPSGQNKKPLIQCFNCKTFKTPLWRRSPEGNTLCNACGLFQKLHGTMRPLSLKSDVIKKRISKKRAKQTDPNIAQNTPSAPATASTSVTTTNAKPIRSRKKSLQQNSLSRVIPEEIIRDNIGNTNNILNVNRGGYNFNSVPSPVLMNSQSYNSSNANFNGASNANLNSNNLMRHNSNTVTPNFRRSSRRSSTSSNTSSSSKSSSRSVVPILPKPSPNSANSQQFNMNMNLMNTTNNVSAGNSVASSPRIISSANFNSNSPLQQNLLSNSFQRQGMNIPRRKMSRNASYSSSFMAASLQQLHEQQQVDVNSNTNTNSNRQNWNSSNSVSTNSRSSNFVSQKPNFDIFNTPVDSPSVSRPSSRKSHTSLLSQQLQNSESNSFISNHKFNNRLSSDSTSPIKYEADVSAGGKISEDNSTKGSSKESSAIADELDWLKFGI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 189 | Phosphorylation | LFPYNSSTSNSNINQ CCCCCCCCCCCCCCC | 31.57 | 20377248 | |
| 205 | Phosphorylation | SINNNSNTNAQSHHS CCCCCCCCCCCCCCC | 31.58 | 21440633 | |
| 209 | Phosphorylation | NSNTNAQSHHSFNIY CCCCCCCCCCCEEEE | 22.28 | 21440633 | |
| 216 | Phosphorylation | SHHSFNIYKLQNNNS CCCCEEEEEECCCCC | 13.52 | 21440633 | |
| 223 | Phosphorylation | YKLQNNNSSSSAMNI EEECCCCCCCCCEEC | 33.45 | 22369663 | |
| 224 | Phosphorylation | KLQNNNSSSSAMNIT EECCCCCCCCCEECC | 30.36 | 22369663 | |
| 225 | Phosphorylation | LQNNNSSSSAMNITN ECCCCCCCCCEECCC | 23.18 | 22369663 | |
| 226 | Phosphorylation | QNNNSSSSAMNITNN CCCCCCCCCEECCCC | 33.22 | 22369663 | |
| 231 | Phosphorylation | SSSAMNITNNNNSNN CCCCEECCCCCCCCC | 27.21 | 23749301 | |
| 236 | Phosphorylation | NITNNNNSNNSNIQH ECCCCCCCCCCCCCC | 39.24 | 22369663 | |
| 239 | Phosphorylation | NNNNSNNSNIQHPFL CCCCCCCCCCCCCCC | 39.29 | 22369663 | |
| 249 | Phosphorylation | QHPFLKKSDSIGLSS CCCCCCCCCCCCCCC | 34.70 | 22369663 | |
| 251 | Phosphorylation | PFLKKSDSIGLSSSN CCCCCCCCCCCCCCC | 26.16 | 22369663 | |
| 255 | Phosphorylation | KSDSIGLSSSNTTNS CCCCCCCCCCCCCCC | 26.89 | 22369663 | |
| 256 | Phosphorylation | SDSIGLSSSNTTNSV CCCCCCCCCCCCCCC | 32.42 | 22369663 | |
| 257 | Phosphorylation | DSIGLSSSNTTNSVR CCCCCCCCCCCCCCC | 34.52 | 22369663 | |
| 259 | Phosphorylation | IGLSSSNTTNSVRKN CCCCCCCCCCCCCCC | 29.33 | 20377248 | |
| 260 | Phosphorylation | GLSSSNTTNSVRKNS CCCCCCCCCCCCCCC | 29.73 | 24961812 | |
| 262 | Phosphorylation | SSSNTTNSVRKNSLI CCCCCCCCCCCCCCC | 22.62 | 23749301 | |
| 267 | Phosphorylation | TNSVRKNSLIKPMSS CCCCCCCCCCCCCCC | 34.21 | 22369663 | |
| 273 | Phosphorylation | NSLIKPMSSTSLANF CCCCCCCCCCCHHHH | 38.70 | 22369663 | |
| 274 | Phosphorylation | SLIKPMSSTSLANFK CCCCCCCCCCHHHHH | 18.76 | 22369663 | |
| 275 | Phosphorylation | LIKPMSSTSLANFKR CCCCCCCCCHHHHHH | 22.06 | 22369663 | |
| 276 | Phosphorylation | IKPMSSTSLANFKRA CCCCCCCCHHHHHHH | 27.68 | 25521595 | |
| 285 | Phosphorylation | ANFKRAASVSSSISN HHHHHHHHCCHHHHC | 22.88 | 22369663 | |
| 287 | Phosphorylation | FKRAASVSSSISNME HHHHHHCCHHHHCCC | 18.84 | 22369663 | |
| 288 | Phosphorylation | KRAASVSSSISNMEP HHHHHCCHHHHCCCC | 29.54 | 22369663 | |
| 289 | Phosphorylation | RAASVSSSISNMEPS HHHHCCHHHHCCCCC | 23.64 | 22369663 | |
| 291 | Phosphorylation | ASVSSSISNMEPSGQ HHCCHHHHCCCCCCC | 31.88 | 22369663 | |
| 296 | Phosphorylation | SISNMEPSGQNKKPL HHHCCCCCCCCCCCC | 39.44 | 22369663 | |
| 320 | Phosphorylation | KTPLWRRSPEGNTLC CCCHHHCCCCCCHHH | 20.80 | 23749301 | |
| 339 | Phosphorylation | LFQKLHGTMRPLSLK HHHHHHCCCCCCHHC | 10.16 | 19823750 | |
| 344 | Phosphorylation | HGTMRPLSLKSDVIK HCCCCCCHHCHHHHH | 36.11 | 19823750 | |
| 370 | Phosphorylation | DPNIAQNTPSAPATA CCCHHHCCCCCCCCC | 13.41 | 23749301 | |
| 372 | Phosphorylation | NIAQNTPSAPATAST CHHHCCCCCCCCCCC | 44.86 | 23749301 | |
| 382 | Phosphorylation | ATASTSVTTTNAKPI CCCCCCCCCCCCCCC | 27.89 | 28889911 | |
| 383 | Phosphorylation | TASTSVTTTNAKPIR CCCCCCCCCCCCCCH | 18.85 | 23749301 | |
| 384 | Phosphorylation | ASTSVTTTNAKPIRS CCCCCCCCCCCCCHH | 24.66 | 23749301 | |
| 395 | Phosphorylation | PIRSRKKSLQQNSLS CCHHCCHHHHHCCHH | 34.15 | 22369663 | |
| 400 | Phosphorylation | KKSLQQNSLSRVIPE CHHHHHCCHHHHCCH | 24.31 | 22369663 | |
| 402 | Phosphorylation | SLQQNSLSRVIPEEI HHHHCCHHHHCCHHH | 25.07 | 22369663 | |
| 469 | Phosphorylation | NNLMRHNSNTVTPNF CCCCCCCCCCCCCCC | 27.96 | 22369663 | |
| 471 | Phosphorylation | LMRHNSNTVTPNFRR CCCCCCCCCCCCCCH | 26.10 | 22369663 | |
| 473 | Phosphorylation | RHNSNTVTPNFRRSS CCCCCCCCCCCCHHC | 15.52 | 22369663 | |
| 487 | Phosphorylation | SRRSSTSSNTSSSSK CCCCCCCCCCCCCCC | 44.19 | 28889911 | |
| 489 | Phosphorylation | RSSTSSNTSSSSKSS CCCCCCCCCCCCCCC | 31.75 | 28889911 | |
| 490 | Phosphorylation | SSTSSNTSSSSKSSS CCCCCCCCCCCCCCC | 32.26 | 28889911 | |
| 491 | Phosphorylation | STSSNTSSSSKSSSR CCCCCCCCCCCCCCC | 36.27 | 28889911 | |
| 492 | Phosphorylation | TSSNTSSSSKSSSRS CCCCCCCCCCCCCCC | 41.37 | 28889911 | |
| 493 | Phosphorylation | SSNTSSSSKSSSRSV CCCCCCCCCCCCCCE | 38.21 | 28889911 | |
| 531 | Phosphorylation | MNTTNNVSAGNSVAS EECCCCCCCCCCCCC | 32.36 | 28889911 | |
| 544 | Phosphorylation | ASSPRIISSANFNSN CCCCEEEECCCCCCC | 22.49 | 22369663 | |
| 545 | Phosphorylation | SSPRIISSANFNSNS CCCEEEECCCCCCCC | 19.47 | 22369663 | |
| 550 | Phosphorylation | ISSANFNSNSPLQQN EECCCCCCCCHHHHH | 34.25 | 22369663 | |
| 552 | Phosphorylation | SANFNSNSPLQQNLL CCCCCCCCHHHHHHH | 27.15 | 22369663 | |
| 560 | Phosphorylation | PLQQNLLSNSFQRQG HHHHHHHCHHHHHCC | 33.33 | 22369663 | |
| 562 | Phosphorylation | QQNLLSNSFQRQGMN HHHHHCHHHHHCCCC | 21.27 | 22369663 | |
| 616 | Phosphorylation | SNRQNWNSSNSVSTN CCCCCCCCCCCCCCC | 23.63 | 22369663 | |
| 617 | Phosphorylation | NRQNWNSSNSVSTNS CCCCCCCCCCCCCCC | 29.88 | 22369663 | |
| 619 | Phosphorylation | QNWNSSNSVSTNSRS CCCCCCCCCCCCCCC | 21.28 | 22369663 | |
| 621 | Phosphorylation | WNSSNSVSTNSRSSN CCCCCCCCCCCCCCC | 22.99 | 22369663 | |
| 622 | Phosphorylation | NSSNSVSTNSRSSNF CCCCCCCCCCCCCCC | 34.75 | 22369663 | |
| 624 | Phosphorylation | SNSVSTNSRSSNFVS CCCCCCCCCCCCCCC | 33.36 | 22369663 | |
| 626 | Phosphorylation | SVSTNSRSSNFVSQK CCCCCCCCCCCCCCC | 29.47 | 22369663 | |
| 627 | Phosphorylation | VSTNSRSSNFVSQKP CCCCCCCCCCCCCCC | 32.93 | 22369663 | |
| 631 | Phosphorylation | SRSSNFVSQKPNFDI CCCCCCCCCCCCCCC | 28.48 | 22369663 | |
| 641 | Phosphorylation | PNFDIFNTPVDSPSV CCCCCCCCCCCCCCC | 17.59 | 22369663 | |
| 645 | Phosphorylation | IFNTPVDSPSVSRPS CCCCCCCCCCCCCCC | 21.22 | 28132839 | |
| 647 | Phosphorylation | NTPVDSPSVSRPSSR CCCCCCCCCCCCCCC | 36.35 | 28132839 | |
| 649 | Phosphorylation | PVDSPSVSRPSSRKS CCCCCCCCCCCCCHH | 42.69 | 21440633 | |
| 652 | Phosphorylation | SPSVSRPSSRKSHTS CCCCCCCCCCHHHHH | 41.48 | 22369663 | |
| 653 | Phosphorylation | PSVSRPSSRKSHTSL CCCCCCCCCHHHHHH | 46.54 | 22369663 | |
| 656 | Phosphorylation | SRPSSRKSHTSLLSQ CCCCCCHHHHHHHHH | 30.78 | 22369663 | |
| 658 | Phosphorylation | PSSRKSHTSLLSQQL CCCCHHHHHHHHHHH | 28.32 | 22369663 | |
| 659 | Phosphorylation | SSRKSHTSLLSQQLQ CCCHHHHHHHHHHHH | 23.14 | 22369663 | |
| 662 | Phosphorylation | KSHTSLLSQQLQNSE HHHHHHHHHHHHCCC | 22.60 | 22369663 | |
| 668 | Phosphorylation | LSQQLQNSESNSFIS HHHHHHCCCCCCCCC | 29.46 | 22369663 | |
| 670 | Phosphorylation | QQLQNSESNSFISNH HHHHCCCCCCCCCCC | 37.28 | 22369663 | |
| 672 | Phosphorylation | LQNSESNSFISNHKF HHCCCCCCCCCCCCC | 32.98 | 22369663 | |
| 675 | Phosphorylation | SESNSFISNHKFNNR CCCCCCCCCCCCCCC | 30.76 | 22369663 | |
| 684 | Phosphorylation | HKFNNRLSSDSTSPI CCCCCCCCCCCCCCC | 28.94 | 22369663 | |
| 685 | Phosphorylation | KFNNRLSSDSTSPIK CCCCCCCCCCCCCCE | 39.92 | 22369663 | |
| 687 | Phosphorylation | NNRLSSDSTSPIKYE CCCCCCCCCCCCEEE | 32.50 | 22369663 | |
| 688 | Phosphorylation | NRLSSDSTSPIKYEA CCCCCCCCCCCEEEE | 43.44 | 22369663 | |
| 689 | Phosphorylation | RLSSDSTSPIKYEAD CCCCCCCCCCEEEEE | 28.69 | 22369663 | |
| 693 | Phosphorylation | DSTSPIKYEADVSAG CCCCCCEEEEECCCC | 19.64 | 22369663 | |
| 708 | Phosphorylation | GKISEDNSTKGSSKE CEECCCCCCCCCCHH | 43.76 | 21440633 | |
| 709 | Phosphorylation | KISEDNSTKGSSKES EECCCCCCCCCCHHH | 45.75 | 21440633 | |
| 712 | Phosphorylation | EDNSTKGSSKESSAI CCCCCCCCCHHHHHH | 39.53 | 21440633 | |
| 713 | Phosphorylation | DNSTKGSSKESSAIA CCCCCCCCHHHHHHH | 49.46 | 25752575 | |
| 716 | Phosphorylation | TKGSSKESSAIADEL CCCCCHHHHHHHHHH | 28.89 | 29734811 | |
| 717 | Phosphorylation | KGSSKESSAIADELD CCCCHHHHHHHHHHH | 25.45 | 21440633 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GLN3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GLN3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GLN3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223; SER-224; SER-225;SER-251; SER-257; THR-275; SER-285; SER-469; THR-471; SER-531;SER-552; SER-562 AND SER-689, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-249; SER-469 ANDSER-689, AND MASS SPECTROMETRY. | |
