| UniProt ID | RRP5_YEAST | |
|---|---|---|
| UniProt AC | Q05022 | |
| Protein Name | rRNA biogenesis protein RRP5 | |
| Gene Name | RRP5 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1729 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.. | |
| Protein Sequence | MVASTKRKRDEDFPLSREDSTKQPSTSSLVRNTEEVSFPRGGASALTPLELKQVANEAASDVLFGNESVKASEPASRPLKKKKTTKKSTSKDSEASSANSDEARAGLIEHVNFKTLKNGSSLLGQISAITKQDLCITFTDGISGYVNLTHISEEFTSILEDLDEDMDSDTDAADEKKSKVEDAEYESSDDEDEKLDKSNELPNLRRYFHIGQWLRCSVIKNTSLEPSTKKSKKKRIELTIEPSSVNIYADEDLVKSTSIQCAVKSIEDHGATLDVGLPGFTGFIAKKDFGNFEKLLPGAVFLGNITKKSDRSIVVNTDFSDKKNKITQISSIDAIIPGQIVDLLCESITKNGIAGKVFGLVSGVVNVSHLRTFSEEDLKHKFVIGSSIRCRIIACLENKSGDKVLILSNLPHILKLEDALRSTEGLDAFPIGYTFESCSIKGRDSEYLYLALDDDRLGKVHSSRVGEIENSENLSSRVLGYSPVDDIYQLSTDPKYLKLKYLRTNDIPIGELLPSCEITSVSSSGIELKIFNGQFKASVPPLHISDTRLVYPERKFKIGSKVKGRVISVNSRGNVHVTLKKSLVNIEDNELPLVSTYENAKNIKEKNEKTLATIQVFKPNGCIISFFGGLSGFLPNSEISEVFVKRPEEHLRLGQTVIVKLLDVDADRRRIIATCKVSNEQAAQQKDTIENIVPGRTIITVHVIEKTKDSVIVEIPDVGLRGVIYVGHLSDSRIEQNRAQLKKLRIGTELTGLVIDKDTRTRVFNMSLKSSLIKDAKKETLPLTYDDVKDLNKDVPMHAYIKSISDKGLFVAFNGKFIGLVLPSYAVDSRDIDISKAFYINQSVTVYLLRTDDKNQKFLLSLKAPKVKEEKKKVESNIEDPVDSSIKSWDDLSIGSIVKAKIKSVKKNQLNVILAANLHGRVDIAEVFDTYEEITDKKQPLSNYKKDDVIKVKIIGNHDVKSHKFLPITHKISKASVLELSMKPSELKSKEVHTKSLEEINIGQELTGFVNNSSGNHLWLTISPVLKARISLLDLADNDSNFSENIESVFPLGSALQVKVASIDREHGFVNAIGKSHVDINMSTIKVGDELPGRVLKIAEKYVLLDLGNKVTGISFITDALNDFSLTLKEAFEDKINNVIPTTVLSVDEQNKKIELSLRPATAKTRSIKSHEDLKQGEIVDGIVKNVNDKGIFVYLSRKVEAFVPVSKLSDSYLKEWKKFYKPMQYVLGKVVTCDEDSRISLTLRESEINGDLKVLKTYSDIKAGDVFEGTIKSVTDFGVFVKLDNTVNVTGLAHITEIADKKPEDLSALFGVGDRVKAIVLKTNPEKKQISLSLKASHFSKEAELASTTTTTTTVDQLEKEDEDEVMADAGFNDSDSESDIGDQNTEVADRKPETSSDGLSLSAGFDWTASILDQAQEEEESDQDQEDFTENKKHKHKRRKENVVQDKTIDINTRAPESVADFERLLIGNPNSSVVWMNYMAFQLQLSEIEKARELAERALKTINFREEAEKLNIWIAMLNLENTFGTEETLEEVFSRACQYMDSYTIHTKLLGIYEISEKFDKAAELFKATAKKFGGEKVSIWVSWGDFLISHNEEQEARTILGNALKALPKRNHIEVVRKFAQLEFAKGDPERGRSLFEGLVADAPKRIDLWNVYVDQEVKAKDKKKVEDLFERIITKKITRKQAKFFFNKWLQFEESEGDEKTIEYVKAKATEYVASHESQKADE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 16 | Phosphorylation | RDEDFPLSREDSTKQ CCCCCCCCCCCCCCC | 33.58 | 17287358 | |
| 20 | Phosphorylation | FPLSREDSTKQPSTS CCCCCCCCCCCCCCH | 32.52 | 17287358 | |
| 21 | Phosphorylation | PLSREDSTKQPSTSS CCCCCCCCCCCCCHH | 46.12 | 23749301 | |
| 22 | Acetylation | LSREDSTKQPSTSSL CCCCCCCCCCCCHHH | 65.25 | 25381059 | |
| 25 | Phosphorylation | EDSTKQPSTSSLVRN CCCCCCCCCHHHCCC | 38.13 | 23749301 | |
| 26 | Phosphorylation | DSTKQPSTSSLVRNT CCCCCCCCHHHCCCC | 29.08 | 30377154 | |
| 27 | Phosphorylation | STKQPSTSSLVRNTE CCCCCCCHHHCCCCC | 26.47 | 30377154 | |
| 28 | Phosphorylation | TKQPSTSSLVRNTEE CCCCCCHHHCCCCCE | 30.85 | 30377154 | |
| 37 | Phosphorylation | VRNTEEVSFPRGGAS CCCCCEECCCCCCCC | 32.58 | 27214570 | |
| 44 | Phosphorylation | SFPRGGASALTPLEL CCCCCCCCCCCHHHH | 27.38 | 22369663 | |
| 47 | Phosphorylation | RGGASALTPLELKQV CCCCCCCCHHHHHHH | 26.08 | 22369663 | |
| 52 | Ubiquitination | ALTPLELKQVANEAA CCCHHHHHHHHHHHH | 33.09 | 15699485 | |
| 60 | Phosphorylation | QVANEAASDVLFGNE HHHHHHHHHHHCCCC | 34.99 | 28152593 | |
| 68 | Phosphorylation | DVLFGNESVKASEPA HHHCCCCCCCCCCCC | 32.68 | 28889911 | |
| 76 | Phosphorylation | VKASEPASRPLKKKK CCCCCCCCCCCCCCC | 45.18 | 23749301 | |
| 80 | Acetylation | EPASRPLKKKKTTKK CCCCCCCCCCCCCCC | 66.29 | 25381059 | |
| 93 | Phosphorylation | KKSTSKDSEASSANS CCCCCCCHHHHHCCH | 38.51 | 28889911 | |
| 96 | Phosphorylation | TSKDSEASSANSDEA CCCCHHHHHCCHHHH | 26.40 | 24961812 | |
| 97 | Phosphorylation | SKDSEASSANSDEAR CCCHHHHHCCHHHHH | 38.22 | 23749301 | |
| 100 | Phosphorylation | SEASSANSDEARAGL HHHHHCCHHHHHHHH | 36.22 | 27214570 | |
| 114 | Acetylation | LIEHVNFKTLKNGSS HHHHCCCEECCCCCH | 47.98 | 24489116 | |
| 115 | Phosphorylation | IEHVNFKTLKNGSSL HHHCCCEECCCCCHH | 38.54 | 27017623 | |
| 130 | Phosphorylation | LGQISAITKQDLCIT HHHHHEECCCCEEEE | 23.52 | 27017623 | |
| 178 | Phosphorylation | DAADEKKSKVEDAEY CHHHHHHHHHHHHCC | 53.66 | 22890988 | |
| 185 | Phosphorylation | SKVEDAEYESSDDED HHHHHHCCCCCCCHH | 23.88 | 19823750 | |
| 187 | Phosphorylation | VEDAEYESSDDEDEK HHHHCCCCCCCHHHH | 37.86 | 25521595 | |
| 188 | Phosphorylation | EDAEYESSDDEDEKL HHHCCCCCCCHHHHC | 36.82 | 25521595 | |
| 229 | Acetylation | TSLEPSTKKSKKKRI CCCCCCCCCCCCCCE | 60.43 | 25381059 | |
| 286 | Acetylation | GFTGFIAKKDFGNFE CCCEEEEECCCCCHH | 48.32 | 24489116 | |
| 287 | Acetylation | FTGFIAKKDFGNFEK CCEEEEECCCCCHHH | 49.63 | 24489116 | |
| 294 | Acetylation | KDFGNFEKLLPGAVF CCCCCHHHHCCCCEE | 51.71 | 24489116 | |
| 294 | Ubiquitination | KDFGNFEKLLPGAVF CCCCCHHHHCCCCEE | 51.71 | 17644757 | |
| 307 | Acetylation | VFLGNITKKSDRSIV EEECCCCCCCCCEEE | 46.62 | 24489116 | |
| 307 | Ubiquitination | VFLGNITKKSDRSIV EEECCCCCCCCCEEE | 46.62 | 17644757 | |
| 308 | Ubiquitination | FLGNITKKSDRSIVV EECCCCCCCCCEEEE | 49.27 | 17644757 | |
| 317 | Phosphorylation | DRSIVVNTDFSDKKN CCEEEECCCCCCCCC | 27.15 | 30377154 | |
| 322 | Acetylation | VNTDFSDKKNKITQI ECCCCCCCCCCEEEE | 57.98 | 24489116 | |
| 356 | Ubiquitination | TKNGIAGKVFGLVSG HHCCCCHHHHHHHCC | 25.93 | 17644757 | |
| 379 | Acetylation | TFSEEDLKHKFVIGS CCCHHHHCCCEEECC | 58.01 | 24489116 | |
| 415 | Acetylation | SNLPHILKLEDALRS CCCHHHHCHHHHHHC | 49.59 | 24489116 | |
| 437 | Phosphorylation | PIGYTFESCSIKGRD CCCEEEEECEECCCC | 14.69 | 27017623 | |
| 439 | Phosphorylation | GYTFESCSIKGRDSE CEEEEECEECCCCCC | 36.29 | 27017623 | |
| 495 | Acetylation | YQLSTDPKYLKLKYL HHCCCCHHHEECEEE | 67.06 | 24489116 | |
| 524 | Phosphorylation | EITSVSSSGIELKIF EEEEECCCCEEEEEE | 35.96 | 27214570 | |
| 674 | Phosphorylation | DRRRIIATCKVSNEQ CCCEEEEEEECCHHH | 11.49 | 19779198 | |
| 676 | Ubiquitination | RRIIATCKVSNEQAA CEEEEEEECCHHHHH | 44.32 | 15699485 | |
| 686 | Acetylation | NEQAAQQKDTIENIV HHHHHHCCCCHHHCC | 44.77 | 24489116 | |
| 686 | Ubiquitination | NEQAAQQKDTIENIV HHHHHHCCCCHHHCC | 44.77 | 15699485 | |
| 688 | Phosphorylation | QAAQQKDTIENIVPG HHHHCCCCHHHCCCC | 36.91 | 28132839 | |
| 769 | Methylation | RVFNMSLKSSLIKDA EEECEEHHHHHCCHH | 30.60 | 20137074 | |
| 769 | Ubiquitination | RVFNMSLKSSLIKDA EEECEEHHHHHCCHH | 30.60 | 17644757 | |
| 774 | Succinylation | SLKSSLIKDAKKETL EHHHHHCCHHCCCCC | 57.85 | 23954790 | |
| 774 | Ubiquitination | SLKSSLIKDAKKETL EHHHHHCCHHCCCCC | 57.85 | 17644757 | |
| 777 | Ubiquitination | SSLIKDAKKETLPLT HHHCCHHCCCCCCCC | 62.37 | 17644757 | |
| 778 | Ubiquitination | SLIKDAKKETLPLTY HHCCHHCCCCCCCCH | 58.62 | 17644757 | |
| 802 | Acetylation | VPMHAYIKSISDKGL CCCEEEEEECCCCCE | 29.12 | 24489116 | |
| 802 | Ubiquitination | VPMHAYIKSISDKGL CCCEEEEEECCCCCE | 29.12 | 24961812 | |
| 807 | Acetylation | YIKSISDKGLFVAFN EEEECCCCCEEEEEC | 51.20 | 24489116 | |
| 857 | Acetylation | RTDDKNQKFLLSLKA ECCCCCCEEEEEEEC | 47.58 | 24489116 | |
| 876 | Phosphorylation | EEKKKVESNIEDPVD HHHHHHHHCCCCCCC | 46.20 | 21551504 | |
| 884 | Phosphorylation | NIEDPVDSSIKSWDD CCCCCCCCCCCCCCC | 33.91 | 30377154 | |
| 885 | Phosphorylation | IEDPVDSSIKSWDDL CCCCCCCCCCCCCCC | 29.58 | 30377154 | |
| 893 | Phosphorylation | IKSWDDLSIGSIVKA CCCCCCCCHHHHHHH | 31.72 | 30377154 | |
| 976 | Phosphorylation | THKISKASVLELSMK CCCCCHHHHHHHHCC | 30.85 | 27017623 | |
| 981 | Phosphorylation | KASVLELSMKPSELK HHHHHHHHCCHHHHC | 18.51 | 27017623 | |
| 985 | Phosphorylation | LELSMKPSELKSKEV HHHHCCHHHHCCCCC | 50.47 | 27017623 | |
| 989 | Phosphorylation | MKPSELKSKEVHTKS CCHHHHCCCCCCCCC | 46.82 | 27017623 | |
| 1101 | Acetylation | RVLKIAEKYVLLDLG HHHHEEEEEEEEECC | 31.47 | 24489116 | |
| 1175 | Acetylation | IKSHEDLKQGEIVDG CCCHHHHHCCCEEEE | 69.45 | 24489116 | |
| 1185 | Acetylation | EIVDGIVKNVNDKGI CEEEEEEECCCCCCE | 53.94 | 24489116 | |
| 1190 | Acetylation | IVKNVNDKGIFVYLS EEECCCCCCEEEEEE | 49.02 | 24489116 | |
| 1199 | Ubiquitination | IFVYLSRKVEAFVPV EEEEEECCEEEEEEH | 40.84 | 17644757 | |
| 1208 | Acetylation | EAFVPVSKLSDSYLK EEEEEHHHCCHHHHH | 52.85 | 24489116 | |
| 1208 | Ubiquitination | EAFVPVSKLSDSYLK EEEEEHHHCCHHHHH | 52.85 | 17644757 | |
| 1212 | Phosphorylation | PVSKLSDSYLKEWKK EHHHCCHHHHHHHHH | 29.05 | 30377154 | |
| 1215 | Acetylation | KLSDSYLKEWKKFYK HCCHHHHHHHHHHHH | 53.98 | 24489116 | |
| 1241 | Phosphorylation | CDEDSRISLTLRESE CCCCCCEEEEEEHHH | 17.75 | 19779198 | |
| 1332 | Phosphorylation | NPEKKQISLSLKASH CCCCCEEEEEEEHHH | 14.93 | 29136822 | |
| 1348 | Phosphorylation | SKEAELASTTTTTTT CCHHHHCCCEECCCC | 38.62 | 19795423 | |
| 1349 | Phosphorylation | KEAELASTTTTTTTV CHHHHCCCEECCCCH | 23.66 | 19795423 | |
| 1350 | Phosphorylation | EAELASTTTTTTTVD HHHHCCCEECCCCHH | 21.46 | 19795423 | |
| 1351 | Phosphorylation | AELASTTTTTTTVDQ HHHCCCEECCCCHHH | 23.41 | 19795423 | |
| 1352 | Phosphorylation | ELASTTTTTTTVDQL HHCCCEECCCCHHHH | 21.76 | 19795423 | |
| 1353 | Phosphorylation | LASTTTTTTTVDQLE HCCCEECCCCHHHHH | 20.55 | 19795423 | |
| 1354 | Phosphorylation | ASTTTTTTTVDQLEK CCCEECCCCHHHHHH | 23.80 | 19795423 | |
| 1355 | Phosphorylation | STTTTTTTVDQLEKE CCEECCCCHHHHHHC | 21.72 | 19795423 | |
| 1376 | Phosphorylation | ADAGFNDSDSESDIG CCCCCCCCCCCCCCC | 44.11 | 19795423 | |
| 1378 | Phosphorylation | AGFNDSDSESDIGDQ CCCCCCCCCCCCCCC | 42.84 | 19795423 | |
| 1380 | Phosphorylation | FNDSDSESDIGDQNT CCCCCCCCCCCCCCC | 38.18 | 19795423 | |
| 1387 | Phosphorylation | SDIGDQNTEVADRKP CCCCCCCCCCCCCCC | 26.63 | 19795423 | |
| 1423 | Phosphorylation | QAQEEEESDQDQEDF HHHHHHCCCCCHHHH | 43.80 | 27214570 | |
| 1449 | Acetylation | KENVVQDKTIDINTR HHHCCCCCEEECCCC | 30.23 | 24489116 | |
| 1543 | Phosphorylation | VFSRACQYMDSYTIH HHHHHHHHHHHCCHH | 11.63 | 27017623 | |
| 1546 | Phosphorylation | RACQYMDSYTIHTKL HHHHHHHHCCHHHHH | 13.98 | 27017623 | |
| 1547 | Phosphorylation | ACQYMDSYTIHTKLL HHHHHHHCCHHHHHH | 12.88 | 27017623 | |
| 1548 | Phosphorylation | CQYMDSYTIHTKLLG HHHHHHCCHHHHHHC | 15.38 | 27017623 | |
| 1551 | Phosphorylation | MDSYTIHTKLLGIYE HHHCCHHHHHHCHHH | 21.38 | 27017623 | |
| 1562 | Acetylation | GIYEISEKFDKAAEL CHHHHHHHHHHHHHH | 52.66 | 24489116 | |
| 1565 | Acetylation | EISEKFDKAAELFKA HHHHHHHHHHHHHHH | 53.26 | 24489116 | |
| 1610 | Acetylation | TILGNALKALPKRNH HHHHHHHHHCCCCCH | 45.53 | 24489116 | |
| 1631 | Acetylation | FAQLEFAKGDPERGR HHCHHHHCCCHHHCH | 69.99 | 24489116 | |
| 1631 | Succinylation | FAQLEFAKGDPERGR HHCHHHHCCCHHHCH | 69.99 | 23954790 | |
| 1650 | Acetylation | GLVADAPKRIDLWNV HHHCCCCCCEECEEE | 64.80 | 24489116 | |
| 1669 | Acetylation | EVKAKDKKKVEDLFE HHHHCCHHHHHHHHH | 72.66 | 24489116 | |
| 1689 | Acetylation | KITRKQAKFFFNKWL HCCHHHHHHHHHHHC | 39.96 | 24489116 | |
| 1721 | Phosphorylation | KATEYVASHESQKAD HHHHHHHCHHHHCCC | 20.11 | 27717283 | |
| 1724 | Phosphorylation | EYVASHESQKADE-- HHHHCHHHHCCCC-- | 31.40 | 17563356 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RRP5_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RRP5_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RRP5_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; SER-37; TYR-185;SER-187; SER-188; SER-1423 AND SER-1724, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; SER-187; SER-188 ANDSER-1724, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; SER-187 AND SER-188,AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-47; SER-187 AND SER-188,AND MASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-47, AND MASSSPECTROMETRY. | |
