| UniProt ID | RNT1_YEAST | |
|---|---|---|
| UniProt AC | Q02555 | |
| Protein Name | Ribonuclease 3 | |
| Gene Name | RNT1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 471 | |
| Subcellular Localization | ||
| Protein Description | DsRNA-specific nuclease that cleaves eukaryotic pre-ribosomal RNA at the U3 snoRNP-dependent A0 site in the 5'-external transcribed spacer (ETS) and in the 3'-ETS. In vitro, cleaves synthetic 5'-ETS RNA A0 site in the absence of snoRNA or other factors. Has an essential growth function in addition to pre-rRNA processing.. | |
| Protein Sequence | MGSKVAGKKKTQNDNKLDNENGSQQRENINTKTLLKGNLKISNYKYLEVIQLEHAVTKLVESYNKIIELSPNLVAYNEAVNNQDRVPVQILPSLSRYQLKLAAELKTLHDLKKDAILTEITDYENEFDTEQKQPILQEISKADMEKLEKLEQVKREKREKIDVNVYENLNEKEDEEEDEGEDSYDPTKAGDIVKATKWPPKLPEIQDLAIRARVFIHKSTIKDKVYLSGSEMINAHNERLEFLGDSILNSVMTLIIYNKFPDYSEGQLSTLRMNLVSNEQIKQWSIMYNFHEKLKTNFDLKDENSNFQNGKLKLYADVFEAYIGGLMEDDPRNNLPKIRKWLRKLAKPVIEEATRNQVALEKTDKLDMNAKRQLYSLIGYASLRLHYVTVKKPTAVDPNSIVECRVGDGTVLGTGVGRNIKIAGIRAAENALRDKKMLDFYAKQRAAIPRSESVLKDPSQKNKKRKFSDTS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 23 | Phosphorylation | KLDNENGSQQRENIN CCCCCCHHHHHHHCC | 34.42 | 28889911 | |
| 36 | Acetylation | INTKTLLKGNLKISN CCHHHHHCCCEEECC | 49.19 | 25381059 | |
| 183 | Phosphorylation | EEDEGEDSYDPTKAG CCCCCCCCCCCCCHH | 27.42 | 28889911 | |
| 295 | Acetylation | YNFHEKLKTNFDLKD HHHHHHHHCCCCCCC | 53.11 | 24489116 | |
| 311 | Acetylation | NSNFQNGKLKLYADV CCCCCCCEEEEEHHH | 50.42 | 24489116 | |
| 451 | Phosphorylation | QRAAIPRSESVLKDP HHHCCCCCHHHHCCH | 28.95 | 30377154 | |
| 453 | Phosphorylation | AAIPRSESVLKDPSQ HCCCCCHHHHCCHHH | 33.71 | 23749301 | |
| 456 | Acetylation | PRSESVLKDPSQKNK CCCHHHHCCHHHHCC | 66.49 | 22865919 | |
| 468 | Phosphorylation | KNKKRKFSDTS---- HCCCCCCCCCC---- | 42.91 | 27717283 | |
| 470 | Phosphorylation | KKRKFSDTS------ CCCCCCCCC------ | 34.83 | 27717283 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RNT1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RNT1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RNT1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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