SODM_YEAST - dbPTM
SODM_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SODM_YEAST
UniProt AC P00447
Protein Name Superoxide dismutase [Mn], mitochondrial
Gene Name SOD2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 233
Subcellular Localization Mitochondrion matrix.
Protein Description Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems..
Protein Sequence MFAKTAAANLTKKGGLSLLSTTARRTKVTLPDLKWDFGALEPYISGQINELHYTKHHQTYVNGFNTAVDQFQELSDLLAKEPSPANARKMIAIQQNIKFHGGGFTNHCLFWENLAPESQGGGEPPTGALAKAIDEQFGSLDELIKLTNTKLAGVQGSGWAFIVKNLSNGGKLDVVQTYNQDTVTGPLVPLVAIDAWEHAYYLQYQNKKADYFKAIWNVVNWKEASRRFDAGKI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
83PhosphorylationDLLAKEPSPANARKM
HHHCCCCCHHHHHHH		37.4228889911
145AcetylationGSLDELIKLTNTKLA
CCHHHHHHHHCCCCC		62.9824489116
147PhosphorylationLDELIKLTNTKLAGV
HHHHHHHHCCCCCCC		35.5228889911
149PhosphorylationELIKLTNTKLAGVQG
HHHHHHCCCCCCCCC		23.3828889911
164AcetylationSGWAFIVKNLSNGGK
CCEEEEEEECCCCCE		47.5624489116
222AcetylationIWNVVNWKEASRRFD
HHHHHCHHHHHHHCC		37.8924489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SODM_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SODM_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SODM_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CYAA_YEASTCYR1genetic
12586694
ATC1_YEASTPMR1genetic
1526970
BSD2_YEASTBSD2genetic
1526970
MRX6_YEASTYNL295Wphysical
18467557
MSH1_YEASTMSH1genetic
19056520
ATC1_YEASTPMR1genetic
17603109
GIS1_YEASTGIS1genetic
21926297
MSN2_YEASTMSN2genetic
21926297
MSN4_YEASTMSN4genetic
21926297
YTA12_YEASTYTA12genetic
21610694
SODM_YEASTSOD2physical
22102021
SODM_YEASTSOD2physical
22077216
SODC_YEASTSOD1genetic
14762569
ATC1_YEASTPMR1genetic
23281478
ALDH4_YEASTALD4genetic
23281478
MPIP_YEASTMIH1genetic
23448552
AIM32_YEASTAIM32genetic
26629948
MCR1_YEASTMCR1genetic
26629948
SEC17_YEASTSEC17genetic
27708008
ALG14_YEASTALG14genetic
27708008
CDC37_YEASTCDC37genetic
27708008
RPB7_YEASTRPB7genetic
27708008
ACT_YEASTACT1genetic
27708008
PSB7_YEASTPRE4genetic
27708008
GPI10_YEASTGPI10genetic
27708008
PAN1_YEASTPAN1genetic
27708008
DPB11_YEASTDPB11genetic
27708008
GWT1_YEASTGWT1genetic
27708008
RFC2_YEASTRFC2genetic
27708008
COFI_YEASTCOF1genetic
27708008
SEC22_YEASTSEC22genetic
27708008
BET5_YEASTBET5genetic
27708008
MED4_YEASTMED4genetic
27708008
PRS10_YEASTRPT4genetic
27708008
MED10_YEASTNUT2genetic
27708008
BOL3_YEASTAIM1genetic
27708008
AVT5_YEASTAVT5genetic
27708008
ATG14_YEASTATG14genetic
27708008
RXT3_YEASTRXT3genetic
27708008
PAA1_YEASTPAA1genetic
27708008
TPS2_YEASTTPS2genetic
27708008
DHAS_YEASTHOM2genetic
27708008
RV167_YEASTRVS167genetic
27708008
CHAC_YEASTGCG1genetic
27708008
KA122_YEASTKAP122genetic
27708008
PIB2_YEASTPIB2genetic
27708008
SGF73_YEASTSGF73genetic
27708008
MRM2_YEASTMRM2genetic
27708008
HUA1_YEASTHUA1genetic
27708008
GPP1_YEASTGPP1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
NFU1_YEASTNFU1genetic
27708008
ERG6_YEASTERG6genetic
27708008
AIM32_YEASTAIM32genetic
27708008
IDH1_YEASTIDH1genetic
27708008
IRA2_YEASTIRA2genetic
27708008
PHM7_YEASTPHM7genetic
27708008
ALDH4_YEASTALD4genetic
27708008
YP107_YEASTYPL107Wgenetic
27708008
ISU1_YEASTISU1genetic
27708008
AIM44_YEASTAIM44genetic
27708008
CHMU_YEASTARO7genetic
27708008
UBA3_YEASTUBA3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SODM_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase.";
Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.;
Mol. Cell. Proteomics 6:1896-1906(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-147 AND THR-149, ANDMASS SPECTROMETRY.

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