dbPTM

HUA1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HUA1_YEAST
UniProt AC	P40325
Protein Name	Proline-rich protein HUA1
Gene Name	HUA1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	198
Subcellular Localization	Cytoplasm .
Protein Description	May be involved in assembly and disassembly of the actin cytoskeleton..
Protein Sequence	MSKDTHDDELPSYEDVIKEEERLQSQPPRPPRPAANLAQGHQSRPHQRPSTMPATSSSQTYAHSHSYTPTSSQPRPPPRPQQNPSLPWTYPPRFYCSKCGNTGYKLKNGRSCKSCWRRFAPQNNVVSAPTYYTNYTMPVYTNAWQGNRPLYVQPGDPRLGGVLCGECRGSGRTRFLLDEDICPLCHGVGRIITQPQRY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSKDTHDDE ------CCCCCCCCC	38.96	22814378
3	Ubiquitination	-----MSKDTHDDEL -----CCCCCCCCCC	66.40	24961812
18	Ubiquitination	PSYEDVIKEEERLQS CCHHHHHHHHHHHHC	59.94	12872131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HUA1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HUA1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HUA1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RUP1_YEAST	RUP1	physical	17079730
RSP5_YEAST	RSP5	physical	17079730
HSE1_YEAST	HSE1	physical	17079730
UBP2_YEAST	UBP2	physical	17079730
RSP5_YEAST	RSP5	physical	11283351
RSP5_YEAST	RSP5	physical	18719252
DIG1_YEAST	DIG1	physical	18719252
HUA1_YEAST	HUA1	physical	18719252
CUE5_YEAST	CUE5	physical	18719252
UBX5_YEAST	UBX5	physical	18719252
ENT2_YEAST	ENT2	physical	18719252
POP7_YEAST	POP7	genetic	27708008
LCB2_YEAST	LCB2	genetic	27708008
CDC1_YEAST	CDC1	genetic	27708008
TSC11_YEAST	TSC11	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
CDC12_YEAST	CDC12	genetic	27708008
VTI1_YEAST	VTI1	genetic	27708008
RNA1_YEAST	RNA1	genetic	27708008
NOG2_YEAST	NOG2	genetic	27708008
SGT1_YEAST	SGT1	genetic	27708008
BUR1_YEAST	SGV1	genetic	27708008
RABX5_HUMAN	RABGEF1	physical	27107014
MED4_HUMAN	MED4	physical	27107014
BIRC2_HUMAN	BIRC2	physical	27107014
TNIP1_HUMAN	TNIP1	physical	27107014
UBQL1_HUMAN	UBQLN1	physical	27107014
CACO2_HUMAN	CALCOCO2	physical	27107014
STAM2_HUMAN	STAM2	physical	27107014
OPTN_HUMAN	OPTN	physical	27107014
UBXN1_HUMAN	UBXN1	physical	27107014
UBC_HUMAN	UBC	physical	27107014
WWP2_HUMAN	WWP2	physical	27107014
DVL2_HUMAN	DVL2	physical	27107014

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HUA1_YEAST

Related Literatures of Post-Translational Modification

Ubiquitylation
Reference	PubMed
"A proteomics approach to understanding protein ubiquitination."; Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.; Nat. Biotechnol. 21:921-926(2003). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-3 AND LYS-18, AND MASSSPECTROMETRY.	12872131 [Abstract]