| UniProt ID | TSC11_YEAST | |
|---|---|---|
| UniProt AC | P40061 | |
| Protein Name | Target of rapamycin complex 2 subunit TSC11 | |
| Gene Name | TSC11 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1430 | |
| Subcellular Localization |
Cell membrane Peripheral membrane protein Cytoplasmic side . Vacuole membrane Peripheral membrane protein Cytoplasmic side . |
|
| Protein Description | Essential component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway. TSC11 may exert its functions through two distinct mechanisms, one mediated by AVO1 and the other mediated by AVO2 and SLM1.. | |
| Protein Sequence | MSIPHSAKQSSPLSSRRRSVTNTTPLLTPRHSRDNSSTQISSAKNITSSSPSTITNESSKRNKQNLVLSTSFISTKRLENSAPSPTSPLMARRTRSTMTKALLNLKAEINNQYQELARLRKKKDDIEHLRDSTISDIYSGSYSTNHLQKHSMRIRANTQLREIDNSIKRVEKHIFDLKQQFDKKRQRSLTTSSSIKADVGSIRNDDGQNNDSEELGDHDSLTDQVTLDDEYLTTPTSGTERNSQQNLNRNSTVNSRNNENHSTLSIPDLDGSNKVNLTGDTEKDLGDLENENQIFTSTTTEAATWLVSDYMQSFQEKNVNPDFIAQKANGLVTLLKEHSEIRKDLVLTSFMSSIQNLLLNGNKLIAASAYRVCRYLINSSIFIDELLELRLDAFIIISLAKDNSFQIEREQALKMVRRFIEYNNGVTQGIMQAIISCVEKPEDSLRHMALETLLELCFVAPEMVKECRGMRVIEGFLQDYTSFSLASVILDTILQLMATHKTRQHFLEDFNVSVLTTVFSDTNTKSNVNVEKMQNASTLISITLNSYNGFMLFSNNNFKPLKQLVSFFQIPICAQYLIDIFLDVLKIKPLPYKPRGRHSHSFKPIPSQYYKECMSVNQRLALIVLILENSEFVPHLLELLNEEDRDDHLVAKGRYLLTEYFNLRMNLVDKKYTSVSKPIYKENFTYVNETFQFKKIAYKMNRNRNTIGMSGIDYAQNIKSFSKNIKENTLLREVDDFRFRRMVYDSKVLQTKDFTRWNWNIINELLEGPLLNKKQLEELVKSTKFIRRLLVFYRPLRLRFSNVNKGAKLSQKYVQVGCQFFKTLTATPEGMKILMDDTKIIPQLASLMFRAMEGNISGNIFNKNKLREKIIFGYFKFIGILTQSKNGVHILTRWNFFTVIYKMFQFESKLGLEFLLLTIPELDLKYSSHCRVIIGKALVVANEKVRIEATKHIGDKLKELLSTKESDLKLKANKVKLQQFKMEMLTRQLYDLSPSVVAVADQALYECIVAGNGSEELGTSFRMFLNQMVFIRSPILFELLSRPYGFQLLNEINFVKEERDSWLSKKNIEYVHIVEEFLKKNESINAKSLTFQQKSRLPLHFYESLTKTEDGILLLSQTGDLVTFMNVIKKYVNGNNMATVENAKEILDLKAALWCVGFIGSTELGIGLLDNYSLVEDIIEVAYNASVTSVRFTAFYVLGLISMTREGCEILDEMGWNCCVSVQDEPIGIALPNRLDRFLSYNEHKWSAFGEYSDEMIVFNKSDGDLIEKCLPIEFDLDKLLKEKDTAENPLNEKIITNKYDNDITSQTITVSGENSSLFANEGLSSPYVTQYRNDDDSIESKVLHIVSQLGNHILSNHAVKEITEINNKYGPRLFENEKMFFKVFNMMSKYRFKPHVRKFLCGLFINNRALENVIRHDNKRDKRPANFTR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSIPHSAKQ ------CCCCCCCCC | 57.01 | 28152593 | |
| 10 | Phosphorylation | IPHSAKQSSPLSSRR CCCCCCCCCCCHHCC | 32.96 | 30377154 | |
| 11 | Phosphorylation | PHSAKQSSPLSSRRR CCCCCCCCCCHHCCC | 27.63 | 25752575 | |
| 19 | Phosphorylation | PLSSRRRSVTNTTPL CCHHCCCCCCCCCCC | 31.33 | 17330950 | |
| 21 | Phosphorylation | SSRRRSVTNTTPLLT HHCCCCCCCCCCCCC | 28.26 | 25752575 | |
| 23 | Phosphorylation | RRRSVTNTTPLLTPR CCCCCCCCCCCCCCC | 22.03 | 23749301 | |
| 24 | Phosphorylation | RRSVTNTTPLLTPRH CCCCCCCCCCCCCCC | 17.63 | 25752575 | |
| 28 | Phosphorylation | TNTTPLLTPRHSRDN CCCCCCCCCCCCCCC | 26.42 | 21440633 | |
| 36 | Phosphorylation | PRHSRDNSSTQISSA CCCCCCCCCCCCCCC | 38.77 | 23749301 | |
| 38 | Phosphorylation | HSRDNSSTQISSAKN CCCCCCCCCCCCCCC | 29.73 | 28889911 | |
| 42 | Phosphorylation | NSSTQISSAKNITSS CCCCCCCCCCCCCCC | 44.91 | 28889911 | |
| 47 | Phosphorylation | ISSAKNITSSSPSTI CCCCCCCCCCCCCCC | 31.76 | 28889911 | |
| 48 | Phosphorylation | SSAKNITSSSPSTIT CCCCCCCCCCCCCCC | 25.64 | 28152593 | |
| 49 | Phosphorylation | SAKNITSSSPSTITN CCCCCCCCCCCCCCC | 37.30 | 25521595 | |
| 50 | Phosphorylation | AKNITSSSPSTITNE CCCCCCCCCCCCCCC | 23.72 | 19823750 | |
| 52 | Phosphorylation | NITSSSPSTITNESS CCCCCCCCCCCCCCH | 34.10 | 28152593 | |
| 53 | Phosphorylation | ITSSSPSTITNESSK CCCCCCCCCCCCCHH | 34.89 | 28152593 | |
| 55 | Phosphorylation | SSSPSTITNESSKRN CCCCCCCCCCCHHHH | 32.78 | 27017623 | |
| 58 | Phosphorylation | PSTITNESSKRNKQN CCCCCCCCHHHHHCC | 43.14 | 21440633 | |
| 59 | Phosphorylation | STITNESSKRNKQNL CCCCCCCHHHHHCCE | 29.47 | 29688323 | |
| 69 | Phosphorylation | NKQNLVLSTSFISTK HHCCEEEEEEECCCC | 17.96 | 28889911 | |
| 70 | Phosphorylation | KQNLVLSTSFISTKR HCCEEEEEEECCCCC | 24.40 | 21551504 | |
| 71 | Phosphorylation | QNLVLSTSFISTKRL CCEEEEEEECCCCCC | 19.73 | 28889911 | |
| 74 | Phosphorylation | VLSTSFISTKRLENS EEEEEECCCCCCCCC | 26.35 | 19779198 | |
| 75 | Phosphorylation | LSTSFISTKRLENSA EEEEECCCCCCCCCC | 18.50 | 19779198 | |
| 81 | Phosphorylation | STKRLENSAPSPTSP CCCCCCCCCCCCCCH | 31.98 | 22369663 | |
| 84 | Phosphorylation | RLENSAPSPTSPLMA CCCCCCCCCCCHHHH | 40.29 | 22369663 | |
| 86 | Phosphorylation | ENSAPSPTSPLMARR CCCCCCCCCHHHHHH | 47.52 | 22369663 | |
| 87 | Phosphorylation | NSAPSPTSPLMARRT CCCCCCCCHHHHHHC | 21.30 | 22369663 | |
| 97 | Phosphorylation | MARRTRSTMTKALLN HHHHCHHHHHHHHHH | 26.10 | 21440633 | |
| 99 | Phosphorylation | RRTRSTMTKALLNLK HHCHHHHHHHHHHHH | 17.16 | 24909858 | |
| 141 | Phosphorylation | ISDIYSGSYSTNHLQ HHHHHCCCCCCCCHH | 15.23 | 28889911 | |
| 142 | Phosphorylation | SDIYSGSYSTNHLQK HHHHCCCCCCCCHHH | 24.04 | 28132839 | |
| 143 | Phosphorylation | DIYSGSYSTNHLQKH HHHCCCCCCCCHHHH | 25.16 | 19779198 | |
| 144 | Phosphorylation | IYSGSYSTNHLQKHS HHCCCCCCCCHHHHH | 20.58 | 24961812 | |
| 166 | Phosphorylation | QLREIDNSIKRVEKH HHHHHHHHHHHHHHH | 26.24 | 28889911 | |
| 190 | Phosphorylation | KKRQRSLTTSSSIKA HHHHHHCCCCCCCEE | 26.36 | 19779198 | |
| 191 | Phosphorylation | KRQRSLTTSSSIKAD HHHHHCCCCCCCEEC | 31.72 | 19779198 | |
| 192 | Phosphorylation | RQRSLTTSSSIKADV HHHHCCCCCCCEECC | 19.49 | 19779198 | |
| 193 | Phosphorylation | QRSLTTSSSIKADVG HHHCCCCCCCEECCC | 33.71 | 19779198 | |
| 194 | Phosphorylation | RSLTTSSSIKADVGS HHCCCCCCCEECCCC | 28.07 | 19779198 | |
| 201 | Phosphorylation | SIKADVGSIRNDDGQ CCEECCCCCCCCCCC | 20.44 | 27214570 | |
| 243 | Phosphorylation | TSGTERNSQQNLNRN CCCCCCCCCCCCCCC | 39.09 | 23749301 | |
| 251 | Phosphorylation | QQNLNRNSTVNSRNN CCCCCCCCCCCCCCC | 30.41 | 23749301 | |
| 255 | Phosphorylation | NRNSTVNSRNNENHS CCCCCCCCCCCCCCC | 31.86 | 23749301 | |
| 262 | Phosphorylation | SRNNENHSTLSIPDL CCCCCCCCEEECCCC | 42.50 | 22369663 | |
| 263 | Phosphorylation | RNNENHSTLSIPDLD CCCCCCCEEECCCCC | 19.58 | 23749301 | |
| 265 | Phosphorylation | NENHSTLSIPDLDGS CCCCCEEECCCCCCC | 31.96 | 22369663 | |
| 272 | Phosphorylation | SIPDLDGSNKVNLTG ECCCCCCCCCEECCC | 32.90 | 22369663 | |
| 706 | Phosphorylation | KMNRNRNTIGMSGID HCCCCCCCCCCCCHH | 18.70 | 29136822 | |
| 710 | Phosphorylation | NRNTIGMSGIDYAQN CCCCCCCCCHHHHHH | 27.64 | 29136822 | |
| 714 | Phosphorylation | IGMSGIDYAQNIKSF CCCCCHHHHHHHHHH | 14.25 | 29136822 | |
| 805 | Ubiquitination | LRFSNVNKGAKLSQK HHCCCCCCCCCCCHH | 56.83 | 17644757 | |
| 808 | Ubiquitination | SNVNKGAKLSQKYVQ CCCCCCCCCCHHHHH | 58.29 | 17644757 | |
| 812 | Ubiquitination | KGAKLSQKYVQVGCQ CCCCCCHHHHHHCCH | 43.97 | 17644757 | |
| 823 | Phosphorylation | VGCQFFKTLTATPEG HCCHHHHHHCCCCCC | 24.96 | 21551504 | |
| 884 | Phosphorylation | FIGILTQSKNGVHIL HHHHHCCCCCCEEEE | 23.89 | 28889911 | |
| 892 | Phosphorylation | KNGVHILTRWNFFTV CCCEEEEECCCHHHH | 32.79 | 28889911 | |
| 1338 | Phosphorylation | QYRNDDDSIESKVLH ECCCCCCCHHHHHHH | 34.94 | 27214570 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TSC11_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TSC11_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TSC11_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19; SER-50; SER-84;THR-86; SER-87 AND SER-166, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-86 AND SER-87, AND MASSSPECTROMETRY. | |
