SPO1_YEAST - dbPTM
SPO1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPO1_YEAST
UniProt AC P53541
Protein Name Putative meiotic phospholipase SPO1
Gene Name SPO1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 631
Subcellular Localization Endoplasmic reticulum membrane
Single-pass membrane protein. Nucleus membrane
Single-pass membrane protein.
Protein Description Regulates spindle pole duplication in meiosis I, but not in mitosis. Required for meiosis I, meiosis II chromosome segregation and spore formation. Binds phosphatidylinositol (4)P mono- and polyphosphates..
Protein Sequence MQKLLFVFSVLLTVVLATAPFQVQCPSSPLIREAKHELCPEETLYLKKKKIKTKNKLIQFLKSLTEAKFSSKFYKRVLKDPPKIGIAISGGGYRSMLVGTGFISQMNDYGLFEYSDYIAGLSGGSWILMDLVVQNFEVKSLLQEWDLEEDLLLGIPEFDISEEEIVTNAKKEYNDNDLKMKKRQGGSLITSSSNFYEQIEEIMNSIEEIPEDYMITKRNLNPLARLKKIFFPNNTFTGTDAKIETFKKVLDFYKSLHLKIKPKKMEGFQISFTDYWGKAIVQRLKKNFDDDPNHSFSFSKLVNSSKKFKECSVPIPIFVANCKNGLLSNVIFEFTPFEFGSWENILRLFVKLPYLGSKIVSGKAEKCINNFDDLGFITATSSSIFNNVLIFIWNLASQSSREAMKALNMVMGIFGLGKEEIFSISKDSSRLETDYAVYQPNPFYLYPEKDNVLTNKNHLYLVDGGEDGENIPLRTLVIPERELDVIFVLDSSSDIDNYPNGSKLKRIFEKLDEENVHYQFPNNVKTFTHPIVIGCNATKRTGHDSFLPIIIYHANANHGNASNTSTFKITYNQSEVSSMLPTGRGVFSNDYDLYYKNCLGCILTKRTMDRLPRKKKFSPFCLQCFKDYCYS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
233N-linked_GlycosylationLKKIFFPNNTFTGTD
HHHEECCCCCCCCCH		55.83-
293N-linked_GlycosylationKNFDDDPNHSFSFSK
HCCCCCCCCCCCHHH		50.89-
303N-linked_GlycosylationFSFSKLVNSSKKFKE
CCHHHHHCCCCCCCC		51.51-
426AcetylationEEIFSISKDSSRLET
HHHHEEECCCCCCCC		61.0222865919
500N-linked_GlycosylationSDIDNYPNGSKLKRI
CCCCCCCCCHHHHHH		57.94-
536N-linked_GlycosylationHPIVIGCNATKRTGH
CCEEEECCCCCCCCC		45.49-
560N-linked_GlycosylationHANANHGNASNTSTF
ECCCCCCCCCCCCEE		32.42-
563N-linked_GlycosylationANHGNASNTSTFKIT
CCCCCCCCCCEEEEE		35.32-
572N-linked_GlycosylationSTFKITYNQSEVSSM
CEEEEEECHHHHHHC		30.19-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPO1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPO1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPO1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SPO23_YEASTSPO23physical
10688190
CWP1_YEASTCWP1genetic
10855497
SPO19_YEASTSPO19genetic
18756268
CWP1_YEASTCWP1genetic
18756268
ATG26_YEASTATG26genetic
18756268
SPO71_YEASTSPO71genetic
22611022
SPO73_YEASTSPO73genetic
26605945
SPO71_YEASTSPO71genetic
26605945
YRA2_YEASTYRA2genetic
27708008
LPLA_YEASTAIM22genetic
27708008
FABG_YEASTOAR1genetic
27708008
VPS51_YEASTVPS51genetic
27708008
ACE2_YEASTACE2genetic
27708008
TAL1_YEASTTAL1genetic
27708008
ZRC1_YEASTZRC1genetic
27708008
YNO4_YEASTYNL144Cgenetic
27708008
SFL1_YEASTSFL1genetic
27708008
SUCA_YEASTLSC1genetic
27708008
LIPA_YEASTLIP5genetic
27708008
PHSG_YEASTGPH1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPO1_YEAST

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Related Literatures of Post-Translational Modification

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