| UniProt ID | ACE2_YEAST | |
|---|---|---|
| UniProt AC | P21192 | |
| Protein Name | Metallothionein expression activator | |
| Gene Name | ACE2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 770 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Plays a role in regulating basal-level expression of CUP1. Activates EGT2 transcription in the absence of SWI5.. | |
| Protein Sequence | MDNVVDPWYINPSGFAKDTQDEEYVQHHDNVNPTIPPPDNYILNNENDDGLDNLLGMDYYNIDDLLTQELRDLDIPLVPSPKTGDGSSDKKNIDRTWNLGDENNKVSHYSKKSMSSHKRGLSGTAIFGFLGHNKTLSISSLQQSILNMSKDPQPMELINELGNHNTVKNNNDDFDHIRENDGENSYLSQVLLKQQEELRIALEKQKEVNEKLEKQLRDNQIQQEKLRKVLEEQEEVAQKLVSGATNSNSKPGSPVILKTPAMQNGRMKDNAIIVTTNSANGGYQFPPPTLISPRMSNTSINGSPSRKYHRQRYPNKSPESNGLNLFSSNSGYLRDSELLSFSPQNYNLNLDGLTYNDHNNTSDKNNNDKKNSTGDNIFRLFEKTSPGGLSISPRINGNSLRSPFLVGTDKSRDDRYAAGTFTPRTQLSPIHKKRESVVSTVSTISQLQDDTEPIHMRNTQNPTLRNANALASSSVLPPIPGSSNNTPIKNSLPQKHVFQHTPVKAPPKNGSNLAPLLNAPDLTDHQLEIKTPIRNNSHCEVESYPQVPPVTHDIHKSPTLHSTSPLPDEIIPRTTPMKITKKPTTLPPGTIDQYVKELPDKLFECLYPNCNKVFKRRYNIRSHIQTHLQDRPYSCDFPGCTKAFVRNHDLIRHKISHNAKKYICPCGKRFNREDALMVHRSRMICTGGKKLEHSINKKLTSPKKSLLDSPHDTSPVKETIARDKDGSVLMKMEEQLRDDMRKHGLLDPPPSTAAHEQNSNRTLSNETDAL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 80 | Phosphorylation | LDIPLVPSPKTGDGS CCCCCCCCCCCCCCC | 31.39 | 17330950 | |
| 87 | Phosphorylation | SPKTGDGSSDKKNID CCCCCCCCCCCCCCC | 39.85 | 28152593 | |
| 88 | Phosphorylation | PKTGDGSSDKKNIDR CCCCCCCCCCCCCCC | 60.00 | 28152593 | |
| 113 | Phosphorylation | VSHYSKKSMSSHKRG CCCCCHHHHCCCCCC | 27.86 | 24961812 | |
| 115 | Phosphorylation | HYSKKSMSSHKRGLS CCCHHHHCCCCCCCC | 36.06 | 24961812 | |
| 116 | Phosphorylation | YSKKSMSSHKRGLSG CCHHHHCCCCCCCCC | 25.12 | 24961812 | |
| 122 | Phosphorylation | SSHKRGLSGTAIFGF CCCCCCCCCEEEEEE | 36.60 | 20573982 | |
| 124 | Phosphorylation | HKRGLSGTAIFGFLG CCCCCCCEEEEEECC | 17.13 | 22369663 | |
| 135 | Phosphorylation | GFLGHNKTLSISSLQ EECCCCCEECHHHHH | 30.93 | 21440633 | |
| 137 | Phosphorylation | LGHNKTLSISSLQQS CCCCCEECHHHHHHH | 26.17 | 21440633 | |
| 140 | Phosphorylation | NKTLSISSLQQSILN CCEECHHHHHHHHHC | 28.64 | 21440633 | |
| 144 | Phosphorylation | SISSLQQSILNMSKD CHHHHHHHHHCCCCC | 18.97 | 21440633 | |
| 149 | Phosphorylation | QQSILNMSKDPQPME HHHHHCCCCCCCHHH | 32.60 | 21440633 | |
| 185 | Phosphorylation | RENDGENSYLSQVLL HHCCCCCCHHHHHHH | 24.13 | 21440633 | |
| 242 | Phosphorylation | EVAQKLVSGATNSNS HHHHHHHHCCCCCCC | 32.90 | 22369663 | |
| 245 | Phosphorylation | QKLVSGATNSNSKPG HHHHHCCCCCCCCCC | 42.58 | 25521595 | |
| 247 | Phosphorylation | LVSGATNSNSKPGSP HHHCCCCCCCCCCCC | 37.82 | 25521595 | |
| 249 | Phosphorylation | SGATNSNSKPGSPVI HCCCCCCCCCCCCEE | 39.79 | 22369663 | |
| 253 | Phosphorylation | NSNSKPGSPVILKTP CCCCCCCCCEEECCH | 25.23 | 22369663 | |
| 259 | Phosphorylation | GSPVILKTPAMQNGR CCCEEECCHHCCCCC | 16.91 | 21440633 | |
| 292 | Phosphorylation | FPPPTLISPRMSNTS CCCCCEECCCCCCCC | 15.01 | 21551504 | |
| 296 | Phosphorylation | TLISPRMSNTSINGS CEECCCCCCCCCCCC | 37.93 | 22369663 | |
| 298 | Phosphorylation | ISPRMSNTSINGSPS ECCCCCCCCCCCCCC | 24.55 | 22369663 | |
| 299 | Phosphorylation | SPRMSNTSINGSPSR CCCCCCCCCCCCCCH | 20.50 | 22369663 | |
| 303 | Phosphorylation | SNTSINGSPSRKYHR CCCCCCCCCCHHHCH | 18.40 | 22369663 | |
| 305 | Phosphorylation | TSINGSPSRKYHRQR CCCCCCCCHHHCHHH | 43.00 | 22369663 | |
| 313 | Phosphorylation | RKYHRQRYPNKSPES HHHCHHHCCCCCCCC | 11.65 | 27017623 | |
| 317 | Phosphorylation | RQRYPNKSPESNGLN HHHCCCCCCCCCCCC | 40.31 | 23749301 | |
| 320 | Phosphorylation | YPNKSPESNGLNLFS CCCCCCCCCCCCCCC | 39.31 | 19779198 | |
| 330 | Phosphorylation | LNLFSSNSGYLRDSE CCCCCCCCCCCCCHH | 30.66 | 30377154 | |
| 342 | Phosphorylation | DSELLSFSPQNYNLN CHHHHCCCCCCCEEC | 23.38 | 28132839 | |
| 372 | Phosphorylation | NNNDKKNSTGDNIFR CCCCCCCCCCHHHHH | 42.52 | 19823750 | |
| 373 | Phosphorylation | NNDKKNSTGDNIFRL CCCCCCCCCHHHHHH | 58.93 | 19823750 | |
| 384 | Phosphorylation | IFRLFEKTSPGGLSI HHHHHHCCCCCCCCC | 32.72 | 22369663 | |
| 385 | Phosphorylation | FRLFEKTSPGGLSIS HHHHHCCCCCCCCCC | 32.39 | 22369663 | |
| 390 | Phosphorylation | KTSPGGLSISPRING CCCCCCCCCCCCCCC | 25.05 | 22369663 | |
| 392 | Phosphorylation | SPGGLSISPRINGNS CCCCCCCCCCCCCCC | 12.54 | 22369663 | |
| 399 | Phosphorylation | SPRINGNSLRSPFLV CCCCCCCCCCCCEEE | 26.93 | 28889911 | |
| 402 | Phosphorylation | INGNSLRSPFLVGTD CCCCCCCCCEEECCC | 25.87 | 21440633 | |
| 420 | Phosphorylation | DDRYAAGTFTPRTQL CCCCCCCCCCCCCCC | 21.43 | 22369663 | |
| 422 | Phosphorylation | RYAAGTFTPRTQLSP CCCCCCCCCCCCCCC | 16.23 | 22369663 | |
| 425 | Phosphorylation | AGTFTPRTQLSPIHK CCCCCCCCCCCCCHH | 34.76 | 22890988 | |
| 428 | Phosphorylation | FTPRTQLSPIHKKRE CCCCCCCCCCHHCHH | 16.40 | 22369663 | |
| 436 | Phosphorylation | PIHKKRESVVSTVST CCHHCHHHHHHHHHH | 31.67 | 19779198 | |
| 442 | Phosphorylation | ESVVSTVSTISQLQD HHHHHHHHHHHHHCC | 21.80 | 19779198 | |
| 472 | Phosphorylation | RNANALASSSVLPPI CCHHHHHHCCCCCCC | 24.81 | 19779198 | |
| 482 | Phosphorylation | VLPPIPGSSNNTPIK CCCCCCCCCCCCCCC | 25.25 | 22369663 | |
| 483 | Phosphorylation | LPPIPGSSNNTPIKN CCCCCCCCCCCCCCC | 39.76 | 22369663 | |
| 486 | Phosphorylation | IPGSSNNTPIKNSLP CCCCCCCCCCCCCCC | 30.55 | 22369663 | |
| 491 | Phosphorylation | NNTPIKNSLPQKHVF CCCCCCCCCCCCCCC | 36.10 | 23749301 | |
| 501 | Phosphorylation | QKHVFQHTPVKAPPK CCCCCCCCCCCCCCC | 20.99 | 25521595 | |
| 511 | Phosphorylation | KAPPKNGSNLAPLLN CCCCCCCCCCHHHHC | 37.76 | 22369663 | |
| 531 | Phosphorylation | DHQLEIKTPIRNNSH CCEEEECCCCCCCCC | 29.61 | 29734811 | |
| 537 | Phosphorylation | KTPIRNNSHCEVESY CCCCCCCCCCEECCC | 32.82 | 21440633 | |
| 551 | Phosphorylation | YPQVPPVTHDIHKSP CCCCCCCCCCCCCCC | 21.43 | 19779198 | |
| 557 | Phosphorylation | VTHDIHKSPTLHSTS CCCCCCCCCCCCCCC | 14.68 | 22369663 | |
| 559 | Phosphorylation | HDIHKSPTLHSTSPL CCCCCCCCCCCCCCC | 44.16 | 22369663 | |
| 562 | Phosphorylation | HKSPTLHSTSPLPDE CCCCCCCCCCCCCCC | 33.42 | 20377248 | |
| 563 | Phosphorylation | KSPTLHSTSPLPDEI CCCCCCCCCCCCCCC | 24.50 | 22369663 | |
| 564 | Phosphorylation | SPTLHSTSPLPDEII CCCCCCCCCCCCCCC | 27.70 | 22369663 | |
| 574 | Phosphorylation | PDEIIPRTTPMKITK CCCCCCCCCCCCCCC | 29.87 | 21440633 | |
| 575 | Phosphorylation | DEIIPRTTPMKITKK CCCCCCCCCCCCCCC | 23.75 | 21440633 | |
| 700 | Phosphorylation | HSINKKLTSPKKSLL HHHHHCCCCCCHHHC | 52.44 | 28889911 | |
| 701 | Phosphorylation | SINKKLTSPKKSLLD HHHHCCCCCCHHHCC | 45.20 | 16445868 | |
| 705 | Phosphorylation | KLTSPKKSLLDSPHD CCCCCCHHHCCCCCC | 40.05 | 22369663 | |
| 709 | Phosphorylation | PKKSLLDSPHDTSPV CCHHHCCCCCCCCCH | 24.89 | 22369663 | |
| 713 | Phosphorylation | LLDSPHDTSPVKETI HCCCCCCCCCHHHHH | 31.71 | 22369663 | |
| 714 | Phosphorylation | LDSPHDTSPVKETIA CCCCCCCCCHHHHHH | 33.48 | 22369663 | |
| 719 | Phosphorylation | DTSPVKETIARDKDG CCCCHHHHHHCCCCC | 17.77 | 28889911 | |
| 727 | Phosphorylation | IARDKDGSVLMKMEE HHCCCCCCEEHHHHH | 23.39 | 25704821 | |
| 751 | Phosphorylation | GLLDPPPSTAAHEQN CCCCCCCCCHHHHHH | 36.13 | 19779198 | |
| 752 | Phosphorylation | LLDPPPSTAAHEQNS CCCCCCCCHHHHHHC | 33.37 | 19779198 | |
| 759 | Phosphorylation | TAAHEQNSNRTLSNE CHHHHHHCCCCCCCC | 27.64 | 19779198 | |
| 762 | Phosphorylation | HEQNSNRTLSNETDA HHHHCCCCCCCCCCC | 38.50 | 21440633 | |
| 764 | Phosphorylation | QNSNRTLSNETDAL- HHCCCCCCCCCCCC- | 31.82 | 20377248 | |
| 767 | Phosphorylation | NRTLSNETDAL---- CCCCCCCCCCC---- | 30.72 | 21551504 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ACE2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ACE2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-249; SER-253; SER-564AND SER-709, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-709, AND MASSSPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-428 AND THR-501, ANDMASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80 AND SER-122, AND MASSSPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-701, AND MASSSPECTROMETRY. | |
