| UniProt ID | MCA1_YEAST | |
|---|---|---|
| UniProt AC | Q08601 | |
| Protein Name | Metacaspase-1 | |
| Gene Name | MCA1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 432 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Mediates cell death (apoptosis) triggered by oxygen stress, salt stress or chronological aging. Regulated cell death can prevent a release of toxic cellular components, thus avoiding necrotic collapse of the colony, and can also provide nutrients for healthy cells. Therefore, regulated cell death in yeast colonies can be as important for their development as are apoptosis and related processes that occur within metazoa. Promotes the removal of insoluble protein aggregates during normal growth.. | |
| Protein Sequence | MYPGSGRYTYNNAGGNNGYQRPMAPPPNQQYGQQYGQQYEQQYGQQYGQQNDQQFSQQYAPPPGPPPMAYNRPVYPPPQFQQEQAKAQLSNGYNNPNVNASNMYGPPQNMSLPPPQTQTIQGTDQPYQYSQCTGRRKALIIGINYIGSKNQLRGCINDAHNIFNFLTNGYGYSSDDIVILTDDQNDLVRVPTRANMIRAMQWLVKDAQPNDSLFLHYSGHGGQTEDLDGDEEDGMDDVIYPVDFETQGPIIDDEMHDIMVKPLQQGVRLTALFDSCHSGTVLDLPYTYSTKGIIKEPNIWKDVGQDGLQAAISYATGNRAALIGSLGSIFKTVKGGMGNNVDRERVRQIKFSAADVVMLSGSKDNQTSADAVEDGQNTGAMSHAFIKVMTLQPQQSYLSLLQNMRKELAGKYSQKPQLSSSHPIDVNLQFIM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 137 | Ubiquitination | SQCTGRRKALIIGIN CCCCCCCEEEEEEEE | 46.30 | 17644757 | |
| 149 | Ubiquitination | GINYIGSKNQLRGCI EEEECCCHHHHHHHH | 43.42 | 23749301 | |
| 325 | Phosphorylation | NRAALIGSLGSIFKT CHHHHHHHHHHHHHH | 23.67 | 28152593 | |
| 328 | Phosphorylation | ALIGSLGSIFKTVKG HHHHHHHHHHHHHHC | 30.09 | 28152593 | |
| 331 | Ubiquitination | GSLGSIFKTVKGGMG HHHHHHHHHHHCCCC | 51.22 | 23749301 | |
| 331 | Acetylation | GSLGSIFKTVKGGMG HHHHHHHHHHHCCCC | 51.22 | 25381059 | |
| 334 | Ubiquitination | GSIFKTVKGGMGNNV HHHHHHHHCCCCCCC | 55.78 | 23749301 | |
| 334 | Acetylation | GSIFKTVKGGMGNNV HHHHHHHHCCCCCCC | 55.78 | 25381059 | |
| 352 | Phosphorylation | RVRQIKFSAADVVML HHHHHHHCHHCEEEE | 19.97 | 22369663 | |
| 360 | Phosphorylation | AADVVMLSGSKDNQT HHCEEEECCCCCCCC | 23.95 | 22369663 | |
| 362 | Phosphorylation | DVVMLSGSKDNQTSA CEEEECCCCCCCCCH | 33.20 | 22369663 | |
| 367 | Phosphorylation | SGSKDNQTSADAVED CCCCCCCCCHHHHHC | 31.94 | 29136822 | |
| 368 | Phosphorylation | GSKDNQTSADAVEDG CCCCCCCCHHHHHCC | 17.87 | 30377154 | |
| 378 | Phosphorylation | AVEDGQNTGAMSHAF HHHCCCCCCHHHHHE | 20.59 | 29136822 | |
| 382 | Phosphorylation | GQNTGAMSHAFIKVM CCCCCHHHHHEEEHH | 15.89 | 29136822 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MCA1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MCA1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MCA1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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