| UniProt ID | RFC5_YEAST | |
|---|---|---|
| UniProt AC | P38251 | |
| Protein Name | Replication factor C subunit 5 | |
| Gene Name | RFC5 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 354 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Component of ATP-dependent clamp loader (RFC and RFC-like) complexes for DNA clamps, such as the POL30/PCNA homotrimer and the checkpoint clamp DDC1:MEC3:RAD17 complex. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Component of the replication factor C (RFC or activator 1) complex which loads POL30/PCNA and acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. Component of the RFC-like RAD24-RFC complex which loads the checkpoint clamp DDC1:MEC3:RAD17 complex and is involved in DNA repair pathways. Component of the RFC-like ELG1-RFC complex which appears to have a role in DNA replication, replication fork re-start, recombination and repair.. | |
| Protein Sequence | MSLWVDKYRPKSLNALSHNEELTNFLKSLSDQPRDLPHLLLYGPNGTGKKTRCMALLESIFGPGVYRLKIDVRQFVTASNRKLELNVVSSPYHLEITPSDMGNNDRIVIQELLKEVAQMEQVDFQDSKDGLAHRYKCVIINEANSLTKDAQAALRRTMEKYSKNIRLIMVCDSMSPIIAPIKSRCLLIRCPAPSDSEISTILSDVVTNERIQLETKDILKRIAQASNGNLRVSLLMLESMALNNELALKSSSPIIKPDWIIVIHKLTRKIVKERSVNSLIECRAVLYDLLAHCIPANIILKELTFSLLDVETLNTTNKSSIIEYSSVFDERLSLGNKAIFHLEGFIAKVMCCLD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSLWVDKYR ------CCCCCCCCC | 30.82 | 21126336 | |
| 8 | Phosphorylation | MSLWVDKYRPKSLNA CCCCCCCCCCCCHHH | 27.90 | 21126336 | |
| 11 | Ubiquitination | WVDKYRPKSLNALSH CCCCCCCCCHHHHCC | 59.59 | 17644757 | |
| 27 | Ubiquitination | EELTNFLKSLSDQPR HHHHHHHHHHCCCCC | 45.25 | 17644757 | |
| 173 | Phosphorylation | RLIMVCDSMSPIIAP EEEEEECCCCCCCHH | 18.94 | 24603354 | |
| 175 | Phosphorylation | IMVCDSMSPIIAPIK EEEECCCCCCCHHCC | 19.52 | 26447709 | |
| 216 | Acetylation | ERIQLETKDILKRIA CCEECCHHHHHHHHH | 33.14 | 24489116 | |
| 256 | Acetylation | KSSSPIIKPDWIIVI CCCCCCCCCCEEEEE | 37.33 | 24489116 | |
| 301 | Ubiquitination | IPANIILKELTFSLL CCHHHHHHHHHHHHC | 40.02 | 17644757 | |
| 337 | Ubiquitination | ERLSLGNKAIFHLEG CHHCCCCHHHHHHHH | 40.85 | 17644757 | |
| 348 | Ubiquitination | HLEGFIAKVMCCLD- HHHHHHHHHHHCCC- | 26.19 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RFC5_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RFC5_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RFC5_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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