IVY1_YEAST - dbPTM
IVY1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IVY1_YEAST
UniProt AC Q04934
Protein Name Protein IVY1
Gene Name IVY1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 453
Subcellular Localization Vacuole membrane
Peripheral membrane protein . Binds to various phospholipids.
Protein Description May be required for vacuolar fusion. Overexpression leads to fragmentation of vacuoles, missorting of the vacuolar enzyme carboxypeptidase Y (CPY) to the exterior of the cell and accumulation of multivesicular bodies inside the cell..
Protein Sequence MPDNNTEQLQGSPSSDQRLRVDWDNGNHFDVSPDRYAPHLSEFYPIVNSKRPVASSAGSENNDHLDDMNHLRSSKVYSKARRASSITSGTSTINDLQTLITKRDVKETQEALSTLLRNSNAYSDSLLKTSQNGAEIAHSLENIAKLKGCNDETAEKLLSASGLFYLLSNHQLIMSKYFNDLLGDNLIDDIDEFELQTKIMENKFKAQSKEQSLKLKLQERHNFDISKRKIRNLISYRESLSSLQARLDQLETLKHDFYMDSYELVENTCNKVLSKVATVSRAQVEISENIARKGWSGGGLDELLCDADDPFSKKADGPYGTIGGDGETAGEAYNSDEETGGNDVVLNELLEGTSQPSTSKTSLPKSKGSSTVSTPNHSQSSSNKDGVRNNGGGKNGEDEDTDNLMGTENSFSLPPTRNSAEETTQTFKQLSIKEDNDNHSSDTDGMQDQSSNI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MPDNNTEQLQGSP
--CCCCCCCHHCCCC		31.2228132839
12PhosphorylationNTEQLQGSPSSDQRL
CCCHHCCCCCCCCCE		14.5122369663
14PhosphorylationEQLQGSPSSDQRLRV
CHHCCCCCCCCCEEE		48.5222369663
15PhosphorylationQLQGSPSSDQRLRVD
HHCCCCCCCCCEEEE		40.9422369663
32PhosphorylationNGNHFDVSPDRYAPH
CCCCCCCCHHHCCCC		23.9525704821
41PhosphorylationDRYAPHLSEFYPIVN
HHCCCCHHHHCHHHC		23.7228889911
49PhosphorylationEFYPIVNSKRPVASS
HHCHHHCCCCCCCCC		21.1028889911
55PhosphorylationNSKRPVASSAGSENN
CCCCCCCCCCCCCCC		22.4322369663
56PhosphorylationSKRPVASSAGSENND
CCCCCCCCCCCCCCC		27.2322369663
59PhosphorylationPVASSAGSENNDHLD
CCCCCCCCCCCCCHH		36.5522369663
73PhosphorylationDDMNHLRSSKVYSKA
HHHHHHHHHHHHHHH		40.6519823750
74PhosphorylationDMNHLRSSKVYSKAR
HHHHHHHHHHHHHHH		21.5119823750
84PhosphorylationYSKARRASSITSGTS
HHHHHHHHCCCCCCC		22.0622369663
85PhosphorylationSKARRASSITSGTST
HHHHHHHCCCCCCCH		28.9722369663
87PhosphorylationARRASSITSGTSTIN
HHHHHCCCCCCCHHH		24.0522369663
88PhosphorylationRRASSITSGTSTIND
HHHHCCCCCCCHHHH		38.1022369663
90PhosphorylationASSITSGTSTINDLQ
HHCCCCCCCHHHHHH		23.5922369663
91PhosphorylationSSITSGTSTINDLQT
HCCCCCCCHHHHHHH		30.7122369663
92PhosphorylationSITSGTSTINDLQTL
CCCCCCCHHHHHHHH		24.5220377248
98PhosphorylationSTINDLQTLITKRDV
CHHHHHHHHHHHCCH		27.6822369663
101PhosphorylationNDLQTLITKRDVKET
HHHHHHHHHCCHHHH		24.1222369663
119PhosphorylationLSTLLRNSNAYSDSL
HHHHHHCCCCCCCHH		19.1921126336
123PhosphorylationLRNSNAYSDSLLKTS
HHCCCCCCCHHHHHC		20.5021126336
239PhosphorylationNLISYRESLSSLQAR
HHHHHHHHHHHHHHH		25.2630377154
241PhosphorylationISYRESLSSLQARLD
HHHHHHHHHHHHHHH		37.9823749301
242PhosphorylationSYRESLSSLQARLDQ
HHHHHHHHHHHHHHH		29.7823749301
328PhosphorylationTIGGDGETAGEAYNS
CCCCCCCCCCHHCCC		45.5521551504
333PhosphorylationGETAGEAYNSDEETG
CCCCCHHCCCCCCCC		15.7621440633
335PhosphorylationTAGEAYNSDEETGGN
CCCHHCCCCCCCCCC		33.4520377248
339PhosphorylationAYNSDEETGGNDVVL
HCCCCCCCCCCCHHH		48.6321551504
370PhosphorylationLPKSKGSSTVSTPNH
CCCCCCCCCCCCCCC		41.3123749301
371PhosphorylationPKSKGSSTVSTPNHS
CCCCCCCCCCCCCCC		21.8521551504
373PhosphorylationSKGSSTVSTPNHSQS
CCCCCCCCCCCCCCC		37.9325371407
374PhosphorylationKGSSTVSTPNHSQSS
CCCCCCCCCCCCCCC		24.6323749301
380PhosphorylationSTPNHSQSSSNKDGV
CCCCCCCCCCCCCCC		38.4625371407
381PhosphorylationTPNHSQSSSNKDGVR
CCCCCCCCCCCCCCC		30.2321551504
401PhosphorylationKNGEDEDTDNLMGTE
CCCCCCCCCCCCCCC		25.4123749301
407PhosphorylationDTDNLMGTENSFSLP
CCCCCCCCCCCCCCC		20.3021440633
410PhosphorylationNLMGTENSFSLPPTR
CCCCCCCCCCCCCCC		15.2420377248
412PhosphorylationMGTENSFSLPPTRNS
CCCCCCCCCCCCCCC		39.5220377248
416PhosphorylationNSFSLPPTRNSAEET
CCCCCCCCCCCHHHH		40.3121551504
419PhosphorylationSLPPTRNSAEETTQT
CCCCCCCCHHHHHHH		33.4922369663
423PhosphorylationTRNSAEETTQTFKQL
CCCCHHHHHHHHHHC		18.7328889911
424PhosphorylationRNSAEETTQTFKQLS
CCCHHHHHHHHHHCC		28.9724909858
426PhosphorylationSAEETTQTFKQLSIK
CHHHHHHHHHHCCCC		30.6119779198
431PhosphorylationTQTFKQLSIKEDNDN
HHHHHHCCCCCCCCC		29.1723749301
440PhosphorylationKEDNDNHSSDTDGMQ
CCCCCCCCCCCCCCC		35.8419684113
441PhosphorylationEDNDNHSSDTDGMQD
CCCCCCCCCCCCCCC		36.6621440633
443PhosphorylationNDNHSSDTDGMQDQS
CCCCCCCCCCCCCCC		36.0819795423
450PhosphorylationTDGMQDQSSNI----
CCCCCCCCCCC----		33.3721440633
451PhosphorylationDGMQDQSSNI-----
CCCCCCCCCC-----		32.6719684113
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IVY1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IVY1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IVY1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VPS33_YEASTVPS33genetic
12553664
SPR3_YEASTSPR3physical
22875988
BLI1_YEASTBLI1physical
22875988
AF9_YEASTYAF9physical
22875988
CDC48_YEASTCDC48genetic
27708008
SMT3_YEASTSMT3genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
SAD1_YEASTSAD1genetic
27708008
STT3_YEASTSTT3genetic
27708008
CP51_YEASTERG11genetic
27708008
ARP3_YEASTARP3genetic
27708008
CDC11_YEASTCDC11genetic
27708008
PRS7_YEASTRPT1genetic
27708008
PRP19_YEASTPRP19genetic
27708008
SMC4_YEASTSMC4genetic
27708008
LCB1_YEASTLCB1genetic
27708008
RPC6_YEASTRPC34genetic
27708008
DIM1_YEASTDIM1genetic
27708008
YPT7_YEASTYPT7physical
25999476
VA0E_YEASTVMA9genetic
25999476
VMA22_YEASTVMA22genetic
25999476
VATA_YEASTVMA1genetic
25999476
VPH1_YEASTVPH1genetic
25999476
VATL2_YEASTVMA11genetic
25999476
VATO_YEASTVMA16genetic
25999476
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IVY1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-14; SER-15;SER-59; SER-84; SER-85; SER-88; THR-90; SER-91; THR-92; SER-242 ANDSER-335, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84 AND SER-85, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85, AND MASSSPECTROMETRY.

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