| UniProt ID | STT3_YEAST | |
|---|---|---|
| UniProt AC | P39007 | |
| Protein Name | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 | |
| Gene Name | STT3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 718 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein. |
|
| Protein Description | Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.. | |
| Protein Sequence | MGSDRSCVLSVFQTILKLVIFVAIFGAAISSRLFAVIKFESIIHEFDPWFNYRATKYLVNNSFYKFLNWFDDRTWYPLGRVTGGTLYPGLMTTSAFIWHALRNWLGLPIDIRNVCVLFAPLFSGVTAWATYEFTKEIKDASAGLLAAGFIAIVPGYISRSVAGSYDNEAIAITLLMVTFMFWIKAQKTGSIMHATCAALFYFYMVSAWGGYVFITNLIPLHVFLLILMGRYSSKLYSAYTTWYAIGTVASMQIPFVGFLPIRSNDHMAALGVFGLIQIVAFGDFVKGQISTAKFKVIMMVSLFLILVLGVVGLSALTYMGLIAPWTGRFYSLWDTNYAKIHIPIIASVSEHQPVSWPAFFFDTHFLIWLFPAGVFLLFLDLKDEHVFVIAYSVLCSYFAGVMVRLMLTLTPVICVSAAVALSKIFDIYLDFKTSDRKYAIKPAALLAKLIVSGSFIFYLYLFVFHSTWVTRTAYSSPSVVLPSQTPDGKLALIDDFREAYYWLRMNSDEDSKVAAWWDYGYQIGGMADRTTLVDNNTWNNTHIAIVGKAMASPEEKSYEILKEHDVDYVLVIFGGLIGFGGDDINKFLWMIRISEGIWPEEIKERDFYTAEGEYRVDARASETMRNSLLYKMSYKDFPQLFNGGQATDRVRQQMITPLDVPPLDYFDEVFTSENWMVRIYQLKKDDAQGRTLRDVGELTRSSTKTRRSIKRPELGLRV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 56 | Acetylation | WFNYRATKYLVNNSF CCCHHHHHHHHCCHH | 35.29 | 24489116 | |
| 56 | Ubiquitination | WFNYRATKYLVNNSF CCCHHHHHHHHCCHH | 35.29 | 23749301 | |
| 60 | N-linked_Glycosylation | RATKYLVNNSFYKFL HHHHHHHCCHHHHHH | 35.51 | - | |
| 437 | Ubiquitination | DFKTSDRKYAIKPAA CCCCCCCCCCCCHHH | 43.98 | 23749301 | |
| 474 | Phosphorylation | TWVTRTAYSSPSVVL HCCCCCCCCCCCEEC | 14.74 | 27017623 | |
| 475 | Phosphorylation | WVTRTAYSSPSVVLP CCCCCCCCCCCEECC | 33.05 | 27017623 | |
| 478 | Phosphorylation | RTAYSSPSVVLPSQT CCCCCCCCEECCCCC | 27.14 | 27017623 | |
| 489 | Ubiquitination | PSQTPDGKLALIDDF CCCCCCCCEEEEHHH | 37.66 | 23749301 | |
| 535 | N-linked_Glycosylation | DRTTLVDNNTWNNTH CCEEEEECCCCCCEE | 40.11 | - | |
| 539 | N-linked_Glycosylation | LVDNNTWNNTHIAIV EEECCCCCCEEEEEE | 41.29 | 29301962 | |
| 556 | Succinylation | AMASPEEKSYEILKE CCCCCCHHHHHHHHH | 57.59 | 23954790 | |
| 631 | Acetylation | MRNSLLYKMSYKDFP HHHHHHHHCCCCCCH | 22.72 | 24489116 | |
| 635 | Acetylation | LLYKMSYKDFPQLFN HHHHCCCCCCHHHHC | 45.65 | 24489116 | |
| 647 | Phosphorylation | LFNGGQATDRVRQQM HHCCCCCCHHHHHHC | 19.22 | 22369663 | |
| 683 | 2-Hydroxyisobutyrylation | MVRIYQLKKDDAQGR EEEEEEEECCCCCCC | 38.33 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of STT3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of STT3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of STT3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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