| UniProt ID | SYLC_YEAST | |
|---|---|---|
| UniProt AC | P26637 | |
| Protein Name | Leucine--tRNA ligase, cytoplasmic | |
| Gene Name | CDC60 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1090 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | ||
| Protein Sequence | MSSGLVLENTARRDALIAIEKKYQKIWAEEHQFEIDAPSIEDEPITMDSEELHRTYPKFMSSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKRALFPLGFHCTGMPILACADKLKREAELFGKNFDNVPAEEEEIKEETPAEKDHEDVTKFKAKKSKAAAKKGRGKYQFEIMLQLGIPREEIIKFADAKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDANPYYDAFIRWQMNKLKAAGKIKFGERYTIYSEKDGQACMDHDRQSGEGVTPQEYIGVKIEALEFADDAAKIIDSSSDLDKSKKFYFVAATLRPETMYGQTCCFVSPTIEYGIFDAGDSYFITTERAFKNMSYQKLTPKRGFYKPIVTVPGKAFIGTKIHAPQSVYPELRILPMETVIATKGTGVVTCVPSNSPDDYITTKDLLHKPEYYGIKPEWIDHEIVPIMHTEKYGDLTAKAIVEEKKIQSPKDKNLLAEAKKIAYKEDYYTGTMIYGPYKGEKVEQAKNKVKADMIAAGEAFVYNEPESQVMSRSGDDCIVSLEDQWYVDYGEESWKKQAIECLEGMQLFAPEVKNAFEGVLDWLKNWAVCRTYGLGTRLPWDEKYLVESLSDSTIYQSFYTIAHLLFKDYYGNEIGPLGISADQMTDEVFDYIFQHQDDVKNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALFPKKFWPKGIRANGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFDESNANAAILRLFNLKEWAEEITKESNLRTGEITDFFDIAFEHEMNALIEKTYEQYALTNYKNALKYGLFDFQAARDYYREASGVMHKDLIARYIETQALLLAPIAPHFAEYIYREVLGNQTSVQNAKFPRASKPVDKGVLAALDYLRNLQRSIREGEGQALKKKKGKSAEIDASKPVKLTLLISESFPEWQSQCVEIVRKLFSEQTLDDNKKVREHIEPKEMKRAMPFISLLKQRLANEKPEDVFERELQFSEIDTVKAAARNVKKAAQALKIAEFSAISFPYGAKTGKDIFTGEEVEIPPVTKIVENAVPGNPGVVFQNI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSSGLVLEN ------CCCCEEECC | 44.40 | 24909858 | |
| 2 | Acetylation | ------MSSGLVLEN ------CCCCEEECC | 44.40 | 22814378 | |
| 10 | Phosphorylation | SGLVLENTARRDALI CCEEECCCHHHHHHH | 16.50 | 19823750 | |
| 21 | Acetylation | DALIAIEKKYQKIWA HHHHHHHHHHHHHHH | 51.14 | 24489116 | |
| 39 | Phosphorylation | QFEIDAPSIEDEPIT CCEECCCCCCCCCCC | 40.09 | 22369663 | |
| 46 | Phosphorylation | SIEDEPITMDSEELH CCCCCCCCCCHHHHH | 26.16 | 22369663 | |
| 49 | Phosphorylation | DEPITMDSEELHRTY CCCCCCCHHHHHHHH | 23.34 | 22369663 | |
| 61 | Phosphorylation | RTYPKFMSSMAYPYM HHHHHHHHHHCHHHH | 21.79 | 28889911 | |
| 62 | Phosphorylation | TYPKFMSSMAYPYMN HHHHHHHHHCHHHHC | 8.81 | 27017623 | |
| 65 | Phosphorylation | KFMSSMAYPYMNGVM HHHHHHCHHHHCCEE | 6.05 | 27017623 | |
| 67 | Phosphorylation | MSSMAYPYMNGVMHA HHHHCHHHHCCEEEC | 7.19 | 19779198 | |
| 79 | Phosphorylation | MHAGHCFTLSKVEFS EECCCEEEECEEEEE | 35.20 | 19779198 | |
| 81 | Phosphorylation | AGHCFTLSKVEFSIG CCCEEEECEEEEEEE | 31.43 | 28889911 | |
| 116 | Acetylation | PILACADKLKREAEL CHHHCHHHHHHHHHH | 37.07 | 24489116 | |
| 126 | Acetylation | REAELFGKNFDNVPA HHHHHHCCCCCCCCH | 47.29 | 24489116 | |
| 139 | Acetylation | PAEEEEIKEETPAEK CHHHHHHHCCCCCCC | 53.42 | 24489116 | |
| 142 | Phosphorylation | EEEIKEETPAEKDHE HHHHHCCCCCCCCCC | 28.96 | 22369663 | |
| 146 | Acetylation | KEETPAEKDHEDVTK HCCCCCCCCCCHHHH | 67.50 | 24489116 | |
| 152 | Phosphorylation | EKDHEDVTKFKAKKS CCCCCHHHHHHHHHH | 42.98 | 29136822 | |
| 153 | Acetylation | KDHEDVTKFKAKKSK CCCCHHHHHHHHHHH | 44.72 | 22865919 | |
| 187 | Acetylation | IPREEIIKFADAKYW CCHHHHHHHHCCCHH | 39.91 | 24489116 | |
| 257 | Acetylation | RYTIYSEKDGQACMD CEEEEECCCCCCCCC | 62.31 | 24489116 | |
| 294 | Acetylation | EFADDAAKIIDSSSD HCCHHHHHHCCCCCC | 41.75 | 24489116 | |
| 298 | Phosphorylation | DAAKIIDSSSDLDKS HHHHHCCCCCCCCCC | 22.72 | 30377154 | |
| 304 | 2-Hydroxyisobutyrylation | DSSSDLDKSKKFYFV CCCCCCCCCCCEEEE | 72.04 | - | |
| 358 | Acetylation | FKNMSYQKLTPKRGF HCCCCCHHCCCCCCC | 46.20 | 22865919 | |
| 360 | Phosphorylation | NMSYQKLTPKRGFYK CCCCHHCCCCCCCCC | 33.52 | 27017623 | |
| 367 | Acetylation | TPKRGFYKPIVTVPG CCCCCCCCCCEEECC | 26.46 | 24489116 | |
| 367 | Succinylation | TPKRGFYKPIVTVPG CCCCCCCCCCEEECC | 26.46 | 23954790 | |
| 381 | Acetylation | GKAFIGTKIHAPQSV CCEEECCCCCCCCCC | 27.55 | 24489116 | |
| 399 | Phosphorylation | LRILPMETVIATKGT CEECCCEEEEEECCC | 15.80 | 22369663 | |
| 403 | Phosphorylation | PMETVIATKGTGVVT CCEEEEEECCCCEEE | 20.91 | 22369663 | |
| 404 | Ubiquitination | METVIATKGTGVVTC CEEEEEECCCCEEEE | 45.51 | 15699485 | |
| 414 | Phosphorylation | GVVTCVPSNSPDDYI CEEEECCCCCCCCCC | 29.55 | 23749301 | |
| 416 | Phosphorylation | VTCVPSNSPDDYITT EEECCCCCCCCCCCH | 33.76 | 23749301 | |
| 424 | Ubiquitination | PDDYITTKDLLHKPE CCCCCCHHHHCCCCH | 37.42 | 15699485 | |
| 436 | Acetylation | KPEYYGIKPEWIDHE CCHHCCCCHHHCCCC | 32.30 | 24489116 | |
| 459 | Acetylation | KYGDLTAKAIVEEKK EECCCHHHHHHHHHC | 33.15 | 24489116 | |
| 471 | Acetylation | EKKIQSPKDKNLLAE HHCCCCHHCCCHHHH | 83.21 | 24489116 | |
| 480 | Succinylation | KNLLAEAKKIAYKED CCHHHHHHHHHEECC | 35.90 | 23954790 | |
| 480 | 2-Hydroxyisobutyrylation | KNLLAEAKKIAYKED CCHHHHHHHHHEECC | 35.90 | - | |
| 480 | Acetylation | KNLLAEAKKIAYKED CCHHHHHHHHHEECC | 35.90 | 22865919 | |
| 485 | Acetylation | EAKKIAYKEDYYTGT HHHHHHEECCCCCCC | 34.78 | 24489116 | |
| 499 | Succinylation | TMIYGPYKGEKVEQA CEEECCCCCHHHHHH | 64.82 | 23954790 | |
| 499 | Acetylation | TMIYGPYKGEKVEQA CEEECCCCCHHHHHH | 64.82 | 24489116 | |
| 502 | Acetylation | YGPYKGEKVEQAKNK ECCCCCHHHHHHCHH | 60.79 | 24489116 | |
| 672 | Ubiquitination | IPLPALQKLRREFEY CCHHHHHHHHHHCCC | 44.82 | 23749301 | |
| 672 | Acetylation | IPLPALQKLRREFEY CCHHHHHHHHHHCCC | 44.82 | 24489116 | |
| 732 | Acetylation | LNNSKMSKSTGNFMT ECCCCCCCCCCCCCC | 48.84 | 24489116 | |
| 733 | Phosphorylation | NNSKMSKSTGNFMTL CCCCCCCCCCCCCCH | 33.95 | 22369663 | |
| 734 | Phosphorylation | NSKMSKSTGNFMTLE CCCCCCCCCCCCCHH | 39.62 | 22369663 | |
| 746 | Acetylation | TLEQTVEKFGADAAR CHHHHHHHHCCCHHH | 44.77 | 24489116 | |
| 762 | Phosphorylation | AFADAGDTVEDANFD EECCCCCCHHHCCCC | 25.52 | 29688323 | |
| 771 | Phosphorylation | EDANFDESNANAAIL HHCCCCHHHHHHHHH | 42.99 | 29688323 | |
| 784 | Ubiquitination | ILRLFNLKEWAEEIT HHHHHCHHHHHHHHH | 52.92 | 15699485 | |
| 792 | Acetylation | EWAEEITKESNLRTG HHHHHHHHHCCCCCC | 65.88 | 24489116 | |
| 792 | Ubiquitination | EWAEEITKESNLRTG HHHHHHHHHCCCCCC | 65.88 | 15699485 | |
| 830 | Acetylation | QYALTNYKNALKYGL HHHHCCHHHHHHHCC | 37.50 | 24489116 | |
| 830 | Ubiquitination | QYALTNYKNALKYGL HHHHCCHHHHHHHCC | 37.50 | 23749301 | |
| 834 | Acetylation | TNYKNALKYGLFDFQ CCHHHHHHHCCCCHH | 34.56 | 24489116 | |
| 834 | Ubiquitination | TNYKNALKYGLFDFQ CCHHHHHHHCCCCHH | 34.56 | 24961812 | |
| 856 | Acetylation | EASGVMHKDLIARYI HHHCCCCHHHHHHHH | 35.81 | 24489116 | |
| 896 | Ubiquitination | QTSVQNAKFPRASKP CCCCCCCCCCCCCCC | 64.55 | 23749301 | |
| 896 | Acetylation | QTSVQNAKFPRASKP CCCCCCCCCCCCCCC | 64.55 | 24489116 | |
| 902 | Acetylation | AKFPRASKPVDKGVL CCCCCCCCCCCHHHH | 48.34 | 24489116 | |
| 906 | Acetylation | RASKPVDKGVLAALD CCCCCCCHHHHHHHH | 51.67 | 24489116 | |
| 921 | Phosphorylation | YLRNLQRSIREGEGQ HHHHHHHHHHHCCCH | 17.03 | 22369663 | |
| 937 | Phosphorylation | LKKKKGKSAEIDASK HHHCCCCCCCCCCCC | 39.54 | 23749301 | |
| 980 | Acetylation | EQTLDDNKKVREHIE CCCCCCCHHHHHHCC | 60.69 | 24489116 | |
| 980 | Succinylation | EQTLDDNKKVREHIE CCCCCCCHHHHHHCC | 60.69 | 23954790 | |
| 1009 | Acetylation | KQRLANEKPEDVFER HHHHHCCCCCHHHHH | 54.22 | 24489116 | |
| 1027 | Acetylation | FSEIDTVKAAARNVK CHHHHHHHHHHHHHH | 34.11 | 24489116 | |
| 1058 | Acetylation | PYGAKTGKDIFTGEE CCCCCCCCCCCCCCC | 53.54 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SYLC_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SYLC_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SYLC_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-734, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-142, AND MASSSPECTROMETRY. | |
