LEUR_YEAST - dbPTM
LEUR_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LEUR_YEAST
UniProt AC P08638
Protein Name Regulatory protein LEU3
Gene Name LEU3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 886
Subcellular Localization Nucleus.
Protein Description Factor for control of RNA levels of a group of leucine-specific genes..
Protein Sequence MEGRSDFVATSQSGSEMSHSETRNRTGMNARKRKFACVECRQQKSKCDAHERAPEPCTKCAKKNVPCILKRDFRRTYKRARNEAIEKRFKELTRTLTNLTSDEILKKIEEEQEIVLDNSNFTKEKVKQLRKSAFETTEIEPRSYKTLRGEPISYSTNRRHTDSSPLTLLSSSTNFDPVHSTNVMTDDQLKCLPKSLGDVYLSSSDIAELFQEFATKYHQFLPVVDLSKGAERIYHLSPCLFWVILLIGLRRKFGATDLMTRLSVLVKSVLSEITISPIIRYTPSDKDEPVLNVASVYSVQAFLLYTFWPPLTSSLSADTSWNTIGTAMFQALRVGLNCAGFSKEYASANSELVNEQIRTWICCNVVSQTVASSFGFPAYVSFDYLVISSIRVPNSKSQVDIPNELRQMAQIARFENQIVNTMNSTPASVTGMVSQEEKQPLLHVLNQQLSQLEISLEENNLDDIRKFLLLVAKVHLLTYYFTDVTSQSAGKSNGNIYEGSYSIMELDTSFETKRGLVKVYNAAVNFLIHANSMWEHDPTIIKYFPGLFVLNIWQSACIISKLIHSSLHSMLDVNSGKKAYNNAISLTFNASVLKYDMAYRSSGIMRSIWSLFANMYDAWKNDQKEGGGRLNNDFNLGITIKSRMSVNVFFDCLYILKEKCGMAKLERETKVSTAYNVDEEEEEDEDEEGEEEEEEEELSSKVPENMDSQQLRTRKFTNVRHPEKKARKIIETIPLDPNPINAGSTSSGSSLTTPNSQVANTISYRGILNKMSPREQLNHANLDSSVSTDIKDTEAVNEPLPIGRNAEHPANQPPLSITQMQENTLPATQANSSLLETYPIVQSNPVTTTIKESPNSIMAGWDNWESDMVWRDVDILMNEFAFNPKV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationGRSDFVATSQSGSEM
CCCCCEEECCCCCCC		23.2321440633
11PhosphorylationRSDFVATSQSGSEMS
CCCCEEECCCCCCCC		16.7722369663
13PhosphorylationDFVATSQSGSEMSHS
CCEEECCCCCCCCCH		44.0122369663
15PhosphorylationVATSQSGSEMSHSET
EEECCCCCCCCCHHH		35.0622369663
18PhosphorylationSQSGSEMSHSETRNR
CCCCCCCCCHHHHCC		21.5823749301
20PhosphorylationSGSEMSHSETRNRTG
CCCCCCCHHHHCCCC		33.1024961812
22PhosphorylationSEMSHSETRNRTGMN
CCCCCHHHHCCCCCC		35.9424961812
26PhosphorylationHSETRNRTGMNARKR
CHHHHCCCCCCHHHH		44.3124961812
95PhosphorylationRFKELTRTLTNLTSD
HHHHHHHHHHCCCHH		32.4721440633
97PhosphorylationKELTRTLTNLTSDEI
HHHHHHHHCCCHHHH		27.8028152593
101PhosphorylationRTLTNLTSDEILKKI
HHHHCCCHHHHHHHH		36.0927214570
119PhosphorylationQEIVLDNSNFTKEKV
HCCCCCCCCCCHHHH		32.7523749301
122PhosphorylationVLDNSNFTKEKVKQL
CCCCCCCCHHHHHHH		42.4123749301
163PhosphorylationTNRRHTDSSPLTLLS
CCCCCCCCCCEEEEC		34.7021440633
164PhosphorylationNRRHTDSSPLTLLSS
CCCCCCCCCEEEECC		27.0919779198
167PhosphorylationHTDSSPLTLLSSSTN
CCCCCCEEEECCCCC		29.1019779198
170PhosphorylationSSPLTLLSSSTNFDP
CCCEEEECCCCCCCC		25.9219779198
599PhosphorylationVLKYDMAYRSSGIMR
HHHHHCHHHCCCHHH		12.3727017623
772PhosphorylationRGILNKMSPREQLNH
HHHHHCCCHHHHHCC		23.5522369663
784PhosphorylationLNHANLDSSVSTDIK
HCCCCCCCCCCCCCC		35.4921551504
787PhosphorylationANLDSSVSTDIKDTE
CCCCCCCCCCCCCCC		23.4721551504
788PhosphorylationNLDSSVSTDIKDTEA
CCCCCCCCCCCCCCC		39.3221551504
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LEUR_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LEUR_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LEUR_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PLP1_YEASTPLP1genetic
20093466
PEX3_YEASTPEX3genetic
20093466
COPE_YEASTSEC28genetic
20093466
PFKA2_YEASTPFK2genetic
20093466
PP2A4_YEASTPPG1genetic
20093466
INO4_YEASTINO4genetic
20093466
DSE3_YEASTDSE3genetic
20093466
GGPPS_YEASTBTS1genetic
20093466
PMA2_YEASTPMA2genetic
20093466
BAS1_YEASTBAS1genetic
20959818
IES1_YEASTIES1genetic
20959818
AFT1_YEASTAFT1genetic
21127252
KCS1_YEASTKCS1genetic
21127252
MMS22_YEASTMMS22genetic
21127252
TOS4_YEASTTOS4genetic
21127252
CTK2_YEASTCTK2genetic
21127252
PLP1_YEASTPLP1genetic
27708008
SWI4_YEASTSWI4genetic
27708008
SGF73_YEASTSGF73genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
ARV1_YEASTARV1genetic
27708008
UBX2_YEASTUBX2genetic
27708008
PFKA2_YEASTPFK2genetic
27708008
EOS1_YEASTEOS1genetic
27708008
PP2A4_YEASTPPG1genetic
27708008
BRE5_YEASTBRE5genetic
27708008
PMA2_YEASTPMA2genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LEUR_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-772, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-772, AND MASSSPECTROMETRY.

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