| UniProt ID | SWI4_YEAST | |
|---|---|---|
| UniProt AC | P25302 | |
| Protein Name | Regulatory protein SWI4 | |
| Gene Name | SWI4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1093 | |
| Subcellular Localization | ||
| Protein Description | Part of a complex involved in cell-cycle-dependent transcription. SWI4 and SWI6 are required for formation of the cell-cycle box factor-DNA complex. The repeated element in the upstream region of HO (5'-CACGAAAA-3') is called the cell cycle box (CCB).. | |
| Protein Sequence | MPFDVLISNQKDNTNHQNITPISKSVLLAPHSNHPVIEIATYSETDVYECYIRGFETKIVMRRTKDDWINITQVFKIAQFSKTKRTKILEKESNDMQHEKVQGGYGRFQGTWIPLDSAKFLVNKYEIIDPVVNSILTFQFDPNNPPPKRSKNSILRKTSPGTKITSPSSYNKTPRKKNSSSSTSATTTAANKKGKKNASINQPNPSPLQNLVFQTPQQFQVNSSMNIMNNNDNHTTMNFNNDTRHNLINNISNNSNQSTIIQQQKSIHENSFNNNYSATQKPLQFFPIPTNLQNKNVALNNPNNNDSNSYSHNIDNVINSSNNNNNGNNNNLIIVPDGPMQSQQQQQHHHEYLTNNFNHSMMDSITNGNSKKRRKKLNQSNEQQFYNQQEKIQRHFKLMKQPLLWQSFQNPNDHHNEYCDSNGSNNNNNTVASNGSSIEVFSSNENDNSMNMSSRSMTPFSAGNTSSQNKLENKMTDQEYKQTILTILSSERSSDVDQALLATLYPAPKNFNINFEIDDQGHTPLHWATAMANIPLIKMLITLNANALQCNKLGFNCITKSIFYNNCYKENAFDEIISILKICLITPDVNGRLPFHYLIELSVNKSKNPMIIKSYMDSIILSLGQQDYNLLKICLNYQDNIGNTPLHLSALNLNFEVYNRLVYLGASTDILNLDNESPASIMNKFNTPAGGSNSRNNNTKADRKLARNLPQKNYYQQQQQQQQPQNNVKIPKIIKTQHPDKEDSTADVNIAKTDSEVNESQYLHSNQPNSTNMNTIMEDLSNINSFVTSSVIKDIKSTPSKILENSPILYRRRSQSISDEKEKAKDNENQVEKKKDPLNSVKTAMPSLESPSSLLPIQMSPLGKYSKPLSQQINKLNTKVSSLQRIMGEEIKNLDNEVVETESSISNNKKRLITIAHQIEDAFDSVSNKTPINSISDLQSRIKETSSKLNSEKQNFIQSLEKSQALKLATIVQDEESKVDMNTNSSSHPEKQEDEEPIPKSTSETSSPKNTKADAKFSNTVQESYDVNETLRLATELTILQFKRRMTTLKISEAKSKINSSVKLDKYRNLIGITIENIDSKLDDIEKDLRANA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MPFDVLISNQKDNTN CCCCEEECCCCCCCC | 29.10 | 30377154 | |
| 14 | Phosphorylation | ISNQKDNTNHQNITP ECCCCCCCCCCCCCC | 44.18 | 19823750 | |
| 20 | Phosphorylation | NTNHQNITPISKSVL CCCCCCCCCCCHHEE | 23.32 | 19823750 | |
| 23 | Phosphorylation | HQNITPISKSVLLAP CCCCCCCCHHEEECC | 21.78 | 28889911 | |
| 153 | Phosphorylation | PPKRSKNSILRKTSP CCCCCCCCCCCCCCC | 27.08 | 19823750 | |
| 158 | Phosphorylation | KNSILRKTSPGTKIT CCCCCCCCCCCCCCC | 33.45 | 24961812 | |
| 159 | Phosphorylation | NSILRKTSPGTKITS CCCCCCCCCCCCCCC | 25.11 | 17287358 | |
| 162 | Phosphorylation | LRKTSPGTKITSPSS CCCCCCCCCCCCCHH | 23.74 | 19823750 | |
| 165 | Phosphorylation | TSPGTKITSPSSYNK CCCCCCCCCCHHCCC | 35.82 | 28889911 | |
| 166 | Phosphorylation | SPGTKITSPSSYNKT CCCCCCCCCHHCCCC | 26.68 | 25533186 | |
| 168 | Phosphorylation | GTKITSPSSYNKTPR CCCCCCCHHCCCCCC | 45.26 | 21440633 | |
| 169 | Phosphorylation | TKITSPSSYNKTPRK CCCCCCHHCCCCCCC | 35.79 | 19779198 | |
| 170 | Phosphorylation | KITSPSSYNKTPRKK CCCCCHHCCCCCCCC | 25.64 | 19779198 | |
| 173 | Phosphorylation | SPSSYNKTPRKKNSS CCHHCCCCCCCCCCC | 25.37 | 19684113 | |
| 179 | Phosphorylation | KTPRKKNSSSSTSAT CCCCCCCCCCCCCHH | 40.24 | 27017623 | |
| 181 | Phosphorylation | PRKKNSSSSTSATTT CCCCCCCCCCCHHHH | 37.14 | 28889911 | |
| 182 | Phosphorylation | RKKNSSSSTSATTTA CCCCCCCCCCHHHHH | 28.47 | 28889911 | |
| 183 | Phosphorylation | KKNSSSSTSATTTAA CCCCCCCCCHHHHHC | 25.07 | 29136822 | |
| 184 | Phosphorylation | KNSSSSTSATTTAAN CCCCCCCCHHHHHCH | 26.09 | 29136822 | |
| 186 | Phosphorylation | SSSSTSATTTAANKK CCCCCCHHHHHCHHC | 25.17 | 29136822 | |
| 187 | Phosphorylation | SSSTSATTTAANKKG CCCCCHHHHHCHHCC | 17.72 | 28889911 | |
| 188 | Phosphorylation | SSTSATTTAANKKGK CCCCHHHHHCHHCCC | 21.30 | 28889911 | |
| 255 | Phosphorylation | INNISNNSNQSTIIQ HHHCCCCCCHHHHHH | 40.26 | 19684113 | |
| 258 | Phosphorylation | ISNNSNQSTIIQQQK CCCCCCHHHHHHHHH | 26.31 | 30377154 | |
| 259 | Phosphorylation | SNNSNQSTIIQQQKS CCCCCHHHHHHHHHH | 16.60 | 19684113 | |
| 266 | Phosphorylation | TIIQQQKSIHENSFN HHHHHHHHHHHCCCC | 25.49 | 23810556 | |
| 271 | Phosphorylation | QKSIHENSFNNNYSA HHHHHHCCCCCCCCC | 26.77 | 21440633 | |
| 276 | Phosphorylation | ENSFNNNYSATQKPL HCCCCCCCCCCCCCC | 11.21 | 21440633 | |
| 456 | Phosphorylation | SMNMSSRSMTPFSAG CCCCCCCCCCCCCCC | 29.02 | 29734811 | |
| 458 | Phosphorylation | NMSSRSMTPFSAGNT CCCCCCCCCCCCCCC | 23.56 | 23749301 | |
| 466 | Phosphorylation | PFSAGNTSSQNKLEN CCCCCCCCHHHHHHC | 33.65 | 23749301 | |
| 467 | Phosphorylation | FSAGNTSSQNKLENK CCCCCCCHHHHHHCC | 35.42 | 19779198 | |
| 476 | Phosphorylation | NKLENKMTDQEYKQT HHHHCCCCHHHHHHH | 35.82 | 19779198 | |
| 687 | Phosphorylation | SIMNKFNTPAGGSNS HHHHHCCCCCCCCCC | 20.04 | 23749301 | |
| 692 | Phosphorylation | FNTPAGGSNSRNNNT CCCCCCCCCCCCCCC | 30.62 | 21551504 | |
| 694 | Phosphorylation | TPAGGSNSRNNNTKA CCCCCCCCCCCCCHH | 37.77 | 30377154 | |
| 712 | Acetylation | LARNLPQKNYYQQQQ HHHHCCCHHHHHHHH | 45.00 | 22865919 | |
| 744 | Phosphorylation | QHPDKEDSTADVNIA CCCCCCCCCCCCEEE | 26.96 | 25704821 | |
| 745 | Phosphorylation | HPDKEDSTADVNIAK CCCCCCCCCCCEEEE | 38.92 | 30377154 | |
| 797 | Phosphorylation | SVIKDIKSTPSKILE HHHHHHHCCHHHHHC | 45.98 | 23749301 | |
| 798 | Phosphorylation | VIKDIKSTPSKILEN HHHHHHCCHHHHHCC | 26.95 | 23749301 | |
| 806 | Phosphorylation | PSKILENSPILYRRR HHHHHCCCCCHHHCC | 12.16 | 22369663 | |
| 810 | Phosphorylation | LENSPILYRRRSQSI HCCCCCHHHCCCCCC | 11.64 | 21440633 | |
| 814 | Phosphorylation | PILYRRRSQSISDEK CCHHHCCCCCCCHHH | 26.86 | 21440633 | |
| 816 | Phosphorylation | LYRRRSQSISDEKEK HHHCCCCCCCHHHHH | 25.88 | 19823750 | |
| 818 | Phosphorylation | RRRSQSISDEKEKAK HCCCCCCCHHHHHHH | 44.99 | 19823750 | |
| 840 | Phosphorylation | KKKDPLNSVKTAMPS HHCCHHHHHHHHCCC | 32.45 | 25704821 | |
| 843 | Phosphorylation | DPLNSVKTAMPSLES CHHHHHHHHCCCCCC | 26.49 | 23810556 | |
| 847 | Phosphorylation | SVKTAMPSLESPSSL HHHHHCCCCCCHHHC | 31.51 | 23749301 | |
| 850 | Phosphorylation | TAMPSLESPSSLLPI HHCCCCCCHHHCCCE | 35.06 | 25752575 | |
| 852 | Phosphorylation | MPSLESPSSLLPIQM CCCCCCHHHCCCEEC | 42.78 | 21440633 | |
| 853 | Phosphorylation | PSLESPSSLLPIQMS CCCCCHHHCCCEECC | 36.99 | 28132839 | |
| 860 | Phosphorylation | SLLPIQMSPLGKYSK HCCCEECCCCCCCCH | 10.70 | 28152593 | |
| 870 | Phosphorylation | GKYSKPLSQQINKLN CCCCHHHHHHHHHHH | 28.68 | 23749301 | |
| 875 | Acetylation | PLSQQINKLNTKVSS HHHHHHHHHHHHHHH | 44.75 | 24489116 | |
| 925 | Phosphorylation | QIEDAFDSVSNKTPI HHHHHHHHCCCCCCC | 22.46 | 24961812 | |
| 927 | Phosphorylation | EDAFDSVSNKTPINS HHHHHHCCCCCCCCC | 36.24 | 24961812 | |
| 930 | Phosphorylation | FDSVSNKTPINSISD HHHCCCCCCCCCHHH | 33.38 | 24961812 | |
| 934 | Phosphorylation | SNKTPINSISDLQSR CCCCCCCCHHHHHHH | 24.96 | 24961812 | |
| 936 | Phosphorylation | KTPINSISDLQSRIK CCCCCCHHHHHHHHH | 31.89 | 24961812 | |
| 951 | Phosphorylation | ETSSKLNSEKQNFIQ HHHHHHHHHHHHHHH | 57.52 | 23749301 | |
| 1003 | Phosphorylation | EPIPKSTSETSSPKN CCCCCCCCCCCCCCC | 46.07 | 16445868 | |
| 1007 | Phosphorylation | KSTSETSSPKNTKAD CCCCCCCCCCCCCCC | 47.52 | 16445868 | |
| 1048 | Phosphorylation | QFKRRMTTLKISEAK HHHHHHHHHCHHHHH | 19.40 | 28889911 | |
| 1056 | Phosphorylation | LKISEAKSKINSSVK HCHHHHHHHHCCCCH | 45.90 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SWI4_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SWI4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SWI4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-806 AND SER-816, ANDMASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-159, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-806, AND MASSSPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1003 AND SER-1007, ANDMASS SPECTROMETRY. | |
