| UniProt ID | FKS1_YEAST | |
|---|---|---|
| UniProt AC | P38631 | |
| Protein Name | 1,3-beta-glucan synthase component FKS1 | |
| Gene Name | FKS1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1876 | |
| Subcellular Localization |
Mitochondrion . Cell membrane Multi-pass membrane protein . Localizes to the sites of polarized growth. Colocalizes with cortical actin patches and moves on the cell surface at the sites of cell wall remodeling. Actin patch motility is required for |
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| Protein Description | Alternate catalytic subunit of the 1,3-beta-glucan synthase (GS). Synthesizes 1,3-beta-glucan, a major structural component of the yeast cell wall. Involved in cell wall synthesis, maintenance and cell wall remodeling.. | |
| Protein Sequence | MNTDQQPYQGQTDYTQGPGNGQSQEQDYDQYGQPLYPSQADGYYDPNVAAGTEADMYGQQPPNESYDQDYTNGEYYGQPPNMAAQDGENFSDFSSYGPPGTPGYDSYGGQYTASQMSYGEPNSSGTSTPIYGNYDPNAIAMALPNEPYPAWTADSQSPVSIEQIEDIFIDLTNRLGFQRDSMRNMFDHFMVLLDSRSSRMSPDQALLSLHADYIGGDTANYKKWYFAAQLDMDDEIGFRNMSLGKLSRKARKAKKKNKKAMEEANPEDTEETLNKIEGDNSLEAADFRWKAKMNQLSPLERVRHIALYLLCWGEANQVRFTAECLCFIYKCALDYLDSPLCQQRQEPMPEGDFLNRVITPIYHFIRNQVYEIVDGRFVKRERDHNKIVGYDDLNQLFWYPEGIAKIVLEDGTKLIELPLEERYLRLGDVVWDDVFFKTYKETRTWLHLVTNFNRIWVMHISIFWMYFAYNSPTFYTHNYQQLVDNQPLAAYKWASCALGGTVASLIQIVATLCEWSFVPRKWAGAQHLSRRFWFLCIIFGINLGPIIFVFAYDKDTVYSTAAHVVAAVMFFVAVATIIFFSIMPLGGLFTSYMKKSTRRYVASQTFTAAFAPLHGLDRWMSYLVWVTVFAAKYSESYYFLVLSLRDPIRILSTTAMRCTGEYWWGAVLCKVQPKIVLGLVIATDFILFFLDTYLWYIIVNTIFSVGKSFYLGISILTPWRNIFTRLPKRIYSKILATTDMEIKYKPKVLISQVWNAIIISMYREHLLAIDHVQKLLYHQVPSEIEGKRTLRAPTFFVSQDDNNFETEFFPRDSEAERRISFFAQSLSTPIPEPLPVDNMPTFTVLTPHYAERILLSLREIIREDDQFSRVTLLEYLKQLHPVEWECFVKDTKILAEETAAYEGNENEAEKEDALKSQIDDLPFYCIGFKSAAPEYTLRTRIWASLRSQTLYRTISGFMNYSRAIKLLYRVENPEIVQMFGGNAEGLERELEKMARRKFKFLVSMQRLAKFKPHELENAEFLLRAYPDLQIAYLDEEPPLTEGEEPRIYSALIDGHCEILDNGRRRPKFRVQLSGNPILGDGKSDNQNHALIFYRGEYIQLIDANQDNYLEECLKIRSVLAEFEELNVEQVNPYAPGLRYEEQTTNHPVAIVGAREYIFSENSGVLGDVAAGKEQTFGTLFARTLSQIGGKLHYGHPDFINATFMTTRGGVSKAQKGLHLNEDIYAGMNAMLRGGRIKHCEYYQCGKGRDLGFGTILNFTTKIGAGMGEQMLSREYYYLGTQLPVDRFLTFYYAHPGFHLNNLFIQLSLQMFMLTLVNLSSLAHESIMCIYDRNKPKTDVLVPIGCYNFQPAVDWVRRYTLSIFIVFWIAFVPIVVQELIERGLWKATQRFFCHLLSLSPMFEVFAGQIYSSALLSDLAIGGARYISTGRGFATSRIPFSILYSRFAGSAIYMGARSMLMLLFGTVAHWQAPLLWFWASLSSLIFAPFVFNPHQFAWEDFFLDYRDYIRWLSRGNNQYHRNSWIGYVRMSRARITGFKRKLVGDESEKAAGDASRAHRTNLIMAEIIPCAIYAAGCFIAFTFINAQTGVKTTDDDRVNSVLRIIICTLAPIAVNLGVLFFCMGMSCCSGPLFGMCCKKTGSVMAGIAHGVAVIVHIAFFIVMWVLESFNFVRMLIGVVTCIQCQRLIFHCMTALMLTREFKNDHANTAFWTGKWYGKGMGYMAWTQPSRELTAKVIELSEFAADFVLGHVILICQLPLIIIPKIDKFHSIMLFWLKPSRQIRPPIYSLKQTRLRKRMVKKYCSLYFLVLAIFAGCIIGPAVASAKIHKHIGDSLDGVVHNLFQPINTTNNDTGSQMSTYQSHYYTHTPSLKTWSTIK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 222 | Ubiquitination | GGDTANYKKWYFAAQ CCCCCCCCCEEEEEE | 36.32 | 23749301 | |
| 223 | Ubiquitination | GDTANYKKWYFAAQL CCCCCCCCEEEEEEC | 36.44 | 17644757 | |
| 245 | Ubiquitination | FRNMSLGKLSRKARK HCCCCHHHHHHHHHH | 48.89 | 23749301 | |
| 249 | Ubiquitination | SLGKLSRKARKAKKK CHHHHHHHHHHHHHH | 49.52 | 22817900 | |
| 258 | Ubiquitination | RKAKKKNKKAMEEAN HHHHHHHHHHHHHHC | 51.28 | 17644757 | |
| 259 | Ubiquitination | KAKKKNKKAMEEANP HHHHHHHHHHHHHCC | 63.46 | 23749301 | |
| 269 | Phosphorylation | EEANPEDTEETLNKI HHHCCCHHHHHHHHH | 33.78 | 22369663 | |
| 272 | Phosphorylation | NPEDTEETLNKIEGD CCCHHHHHHHHHCCC | 29.42 | 22369663 | |
| 275 | Acetylation | DTEETLNKIEGDNSL HHHHHHHHHCCCCCC | 45.29 | 24489116 | |
| 275 | Ubiquitination | DTEETLNKIEGDNSL HHHHHHHHHCCCCCC | 45.29 | 23749301 | |
| 281 | Phosphorylation | NKIEGDNSLEAADFR HHHCCCCCCCHHHHH | 32.12 | 21440633 | |
| 292 | Ubiquitination | ADFRWKAKMNQLSPL HHHHHHHHHHCCCHH | 34.36 | 23749301 | |
| 297 | Phosphorylation | KAKMNQLSPLERVRH HHHHHCCCHHHHHHH | 20.06 | 21082442 | |
| 330 | Ubiquitination | ECLCFIYKCALDYLD HHHHHHHHHHHHHHC | 14.28 | 23749301 | |
| 386 | Ubiquitination | KRERDHNKIVGYDDL ECCCCCCCCCCCCCH | 35.04 | 22106047 | |
| 405 | Ubiquitination | WYPEGIAKIVLEDGT CCCCCCEEEEECCCC | 31.28 | 17644757 | |
| 413 | Ubiquitination | IVLEDGTKLIELPLE EEECCCCEEEEEECH | 53.66 | 23749301 | |
| 413 | Acetylation | IVLEDGTKLIELPLE EEECCCCEEEEEECH | 53.66 | 24489116 | |
| 437 | Ubiquitination | VWDDVFFKTYKETRT EECCCCCCHHHHHHH | 39.21 | 23749301 | |
| 444 | Phosphorylation | KTYKETRTWLHLVTN CHHHHHHHHHHHHHC | 39.54 | 27214570 | |
| 737 | Phosphorylation | IYSKILATTDMEIKY HHHHHHHCCCCCCCC | 21.63 | 27017623 | |
| 743 | Acetylation | ATTDMEIKYKPKVLI HCCCCCCCCCCHHHH | 33.64 | 24489116 | |
| 774 | Ubiquitination | LAIDHVQKLLYHQVP HHHHHHHHHHHCCCC | 39.09 | 22106047 | |
| 787 | Acetylation | VPSEIEGKRTLRAPT CCCHHCCCCEEECCE | 29.44 | 24489116 | |
| 787 | Ubiquitination | VPSEIEGKRTLRAPT CCCHHCCCCEEECCE | 29.44 | 23749301 | |
| 794 | Phosphorylation | KRTLRAPTFFVSQDD CCEEECCEEEEECCC | 28.81 | 27017623 | |
| 868 | Phosphorylation | IREDDQFSRVTLLEY HHCCCCCCHHHHHHH | 21.87 | 21177495 | |
| 877 | Ubiquitination | VTLLEYLKQLHPVEW HHHHHHHHHHCCCEE | 50.33 | 17644757 | |
| 889 | Ubiquitination | VEWECFVKDTKILAE CEEEEEEECCHHHHH | 39.15 | 23749301 | |
| 892 | Ubiquitination | ECFVKDTKILAEETA EEEEECCHHHHHHHH | 45.95 | 17644757 | |
| 910 | Ubiquitination | GNENEAEKEDALKSQ CCCCHHHHHHHHHHH | 68.86 | 23749301 | |
| 915 | Ubiquitination | AEKEDALKSQIDDLP HHHHHHHHHHCCCCC | 41.87 | 22817900 | |
| 916 | Phosphorylation | EKEDALKSQIDDLPF HHHHHHHHHCCCCCE | 32.97 | 22369663 | |
| 929 | Ubiquitination | PFYCIGFKSAAPEYT CEEEEEECCCCCCCC | 33.69 | 23749301 | |
| 953 | Phosphorylation | RSQTLYRTISGFMNY HHHHHHHHHHHHCCH | 13.11 | 22369663 | |
| 955 | Phosphorylation | QTLYRTISGFMNYSR HHHHHHHHHHCCHHH | 25.93 | 22369663 | |
| 960 | Phosphorylation | TISGFMNYSRAIKLL HHHHHCCHHHHHHHH | 6.43 | 22369663 | |
| 961 | Phosphorylation | ISGFMNYSRAIKLLY HHHHCCHHHHHHHHH | 15.38 | 22369663 | |
| 965 | Ubiquitination | MNYSRAIKLLYRVEN CCHHHHHHHHHHCCC | 31.30 | 23749301 | |
| 965 | Acetylation | MNYSRAIKLLYRVEN CCHHHHHHHHHHCCC | 31.30 | 24489116 | |
| 992 | Ubiquitination | GLERELEKMARRKFK HHHHHHHHHHHHHHH | 50.95 | 17644757 | |
| 999 | Ubiquitination | KMARRKFKFLVSMQR HHHHHHHHHHHHHHH | 40.60 | 17644757 | |
| 999 | Acetylation | KMARRKFKFLVSMQR HHHHHHHHHHHHHHH | 40.60 | 24489116 | |
| 1009 | Acetylation | VSMQRLAKFKPHELE HHHHHHHCCCHHHHH | 59.52 | 24489116 | |
| 1009 | Ubiquitination | VSMQRLAKFKPHELE HHHHHHHCCCHHHHH | 59.52 | 23749301 | |
| 1011 | Acetylation | MQRLAKFKPHELENA HHHHHCCCHHHHHCH | 44.77 | 22865919 | |
| 1011 | Ubiquitination | MQRLAKFKPHELENA HHHHHCCCHHHHHCH | 44.77 | 23749301 | |
| 1067 | Ubiquitination | DNGRRRPKFRVQLSG CCCCCCCCEEEEECC | 43.95 | 17644757 | |
| 1073 | Phosphorylation | PKFRVQLSGNPILGD CCEEEEECCCCCCCC | 21.31 | 21440633 | |
| 1082 | Acetylation | NPILGDGKSDNQNHA CCCCCCCCCCCCCEE | 60.42 | 24489116 | |
| 1082 | Ubiquitination | NPILGDGKSDNQNHA CCCCCCCCCCCCCEE | 60.42 | 23749301 | |
| 1114 | Ubiquitination | NYLEECLKIRSVLAE CHHHHHHHHHHHHHH | 47.97 | 17644757 | |
| 1172 | Ubiquitination | LGDVAAGKEQTFGTL CCCHHCCCCCCHHHH | 41.75 | 23749301 | |
| 1183 | Phosphorylation | FGTLFARTLSQIGGK HHHHHHHHHHHHCCE | 27.60 | 21440633 | |
| 1185 | Phosphorylation | TLFARTLSQIGGKLH HHHHHHHHHHCCEEC | 21.09 | 22369663 | |
| 1190 | Ubiquitination | TLSQIGGKLHYGHPD HHHHHCCEECCCCCC | 27.20 | 23749301 | |
| 1202 | Phosphorylation | HPDFINATFMTTRGG CCCCCCEEEEECCCC | 14.95 | 24930733 | |
| 1205 | Phosphorylation | FINATFMTTRGGVSK CCCEEEEECCCCCCH | 14.78 | 24930733 | |
| 1215 | Ubiquitination | GGVSKAQKGLHLNED CCCCHHHCCCCCCCC | 69.19 | 23749301 | |
| 1237 | Ubiquitination | MLRGGRIKHCEYYQC HHCCCCCCCCEEEEC | 40.62 | 17644757 | |
| 1246 | Ubiquitination | CEYYQCGKGRDLGFG CEEEECCCCCCCCCC | 59.40 | 17644757 | |
| 1261 | Ubiquitination | TILNFTTKIGAGMGE HHHEEECCCCCCCCH | 35.76 | 17644757 | |
| 1521 | Phosphorylation | NNQYHRNSWIGYVRM CCCCCCCCCHHHHEE | 21.74 | 19779198 | |
| 1537 | Ubiquitination | RARITGFKRKLVGDE HHHHCCCCCHHCCCH | 50.39 | 22817900 | |
| 1539 | Ubiquitination | RITGFKRKLVGDESE HHCCCCCHHCCCHHH | 48.38 | 23749301 | |
| 1545 | Phosphorylation | RKLVGDESEKAAGDA CHHCCCHHHHHHCCH | 49.49 | 23749301 | |
| 1547 | Ubiquitination | LVGDESEKAAGDASR HCCCHHHHHHCCHHH | 53.46 | 23749301 | |
| 1700 | Acetylation | LMLTREFKNDHANTA HHHHHHHCCCCCCCC | 57.63 | 24489116 | |
| 1788 | Ubiquitination | RPPIYSLKQTRLRKR CCCCCCCHHHHHHHH | 43.62 | 23749301 | |
| 1799 | Ubiquitination | LRKRMVKKYCSLYFL HHHHHHHHHHHHHHH | 39.83 | 23749301 | |
| 1804 | Phosphorylation | VKKYCSLYFLVLAIF HHHHHHHHHHHHHHH | 4.41 | 23749301 | |
| 1822 | Phosphorylation | IIGPAVASAKIHKHI HHCHHHHHHHHHHHH | 24.40 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FKS1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FKS1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FKS1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-269, AND MASSSPECTROMETRY. | |
| Ubiquitylation | |
| Reference | PubMed |
| "A subset of membrane-associated proteins is ubiquitinated in responseto mutations in the endoplasmic reticulum degradation machinery."; Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.; Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-910, AND MASSSPECTROMETRY. | |
