| UniProt ID | PRS7_YEAST | |
|---|---|---|
| UniProt AC | P33299 | |
| Protein Name | 26S proteasome regulatory subunit 7 homolog | |
| Gene Name | RPT1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 467 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).. | |
| Protein Sequence | MPPKEDWEKYKAPLEDDDKKPDDDKIVPLTEGDIQVLKSYGAAPYAAKLKQTENDLKDIEARIKEKAGVKESDTGLAPSHLWDIMGDRQRLGEEHPLQVARCTKIIKGNGESDETTTDNNNSGNSNSNSNQQSTDADEDDEDAKYVINLKQIAKFVVGLGERVSPTDIEEGMRVGVDRSKYNIELPLPPRIDPSVTMMTVEEKPDVTYSDVGGCKDQIEKLREVVELPLLSPERFATLGIDPPKGILLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAVGGARFDDGAGGDNEVQRTMLELITQLDGFDPRGNIKVMFATNRPNTLDPALLRPGRIDRKVEFSLPDLEGRANIFRIHSKSMSVERGIRWELISRLCPNSTGAELRSVCTEAGMFAIRARRKVATEKDFLKAVDKVISGYKKFSSTSRYMQYN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Ubiquitination | PPKEDWEKYKAPLED CCHHHHHHHCCCCCC | 48.04 | 15699485 | |
| 11 | Ubiquitination | KEDWEKYKAPLEDDD HHHHHHHCCCCCCCC | 55.38 | 17644757 | |
| 19 | Ubiquitination | APLEDDDKKPDDDKI CCCCCCCCCCCCCCE | 73.52 | 17644757 | |
| 20 | Ubiquitination | PLEDDDKKPDDDKIV CCCCCCCCCCCCCEE | 61.75 | 17644757 | |
| 25 | Ubiquitination | DKKPDDDKIVPLTEG CCCCCCCCEEECCHH | 53.23 | 17644757 | |
| 38 | Acetylation | EGDIQVLKSYGAAPY HHHHHHHHHCCCCCH | 42.65 | 22865919 | |
| 38 | Ubiquitination | EGDIQVLKSYGAAPY HHHHHHHHHCCCCCH | 42.65 | 24961812 | |
| 40 | Phosphorylation | DIQVLKSYGAAPYAA HHHHHHHCCCCCHHH | 14.81 | 21440633 | |
| 48 | Ubiquitination | GAAPYAAKLKQTEND CCCCHHHHHHCCHHH | 48.31 | 23749301 | |
| 48 | Acetylation | GAAPYAAKLKQTEND CCCCHHHHHHCCHHH | 48.31 | 24489116 | |
| 50 | Ubiquitination | APYAAKLKQTENDLK CCHHHHHHCCHHHHH | 55.24 | 17644757 | |
| 57 | Ubiquitination | KQTENDLKDIEARIK HCCHHHHHHHHHHHH | 60.57 | 17644757 | |
| 57 | Acetylation | KQTENDLKDIEARIK HCCHHHHHHHHHHHH | 60.57 | 24489116 | |
| 66 | Ubiquitination | IEARIKEKAGVKESD HHHHHHHHHCCCCCC | 45.50 | 17644757 | |
| 70 | Ubiquitination | IKEKAGVKESDTGLA HHHHHCCCCCCCCCC | 51.05 | 17644757 | |
| 107 | Ubiquitination | ARCTKIIKGNGESDE HCCEEEECCCCCCCC | 50.20 | 22106047 | |
| 150 | Acetylation | AKYVINLKQIAKFVV HHHEEEHHHHHHHHH | 34.86 | 22865919 | |
| 150 | Ubiquitination | AKYVINLKQIAKFVV HHHEEEHHHHHHHHH | 34.86 | 24961812 | |
| 154 | Acetylation | INLKQIAKFVVGLGE EEHHHHHHHHHCCCC | 40.08 | 24489116 | |
| 154 | Ubiquitination | INLKQIAKFVVGLGE EEHHHHHHHHHCCCC | 40.08 | 23749301 | |
| 164 | Phosphorylation | VGLGERVSPTDIEEG HCCCCCCCCCCHHHC | 28.44 | 22369663 | |
| 166 | Phosphorylation | LGERVSPTDIEEGMR CCCCCCCCCHHHCCE | 41.94 | 22369663 | |
| 180 | Ubiquitination | RVGVDRSKYNIELPL EECCCHHHCEEECCC | 43.12 | 24961812 | |
| 180 | Acetylation | RVGVDRSKYNIELPL EECCCHHHCEEECCC | 43.12 | 24489116 | |
| 194 | Phosphorylation | LPPRIDPSVTMMTVE CCCCCCCCCEEEEEE | 26.86 | 19823750 | |
| 196 | Phosphorylation | PRIDPSVTMMTVEEK CCCCCCCEEEEEEEC | 12.93 | 19823750 | |
| 199 | Phosphorylation | DPSVTMMTVEEKPDV CCCCEEEEEEECCCC | 17.59 | 19823750 | |
| 207 | Phosphorylation | VEEKPDVTYSDVGGC EEECCCCCHHHCCCC | 25.37 | 19823750 | |
| 208 | Phosphorylation | EEKPDVTYSDVGGCK EECCCCCHHHCCCCH | 11.61 | 19823750 | |
| 209 | Phosphorylation | EKPDVTYSDVGGCKD ECCCCCHHHCCCCHH | 19.22 | 19823750 | |
| 220 | Ubiquitination | GCKDQIEKLREVVEL CCHHHHHHHHHHHCC | 55.24 | 17644757 | |
| 231 | Phosphorylation | VVELPLLSPERFATL HHCCCCCCHHHHHCC | 32.19 | 21440633 | |
| 244 | Ubiquitination | TLGIDPPKGILLYGP CCCCCCCCEEEEECC | 65.06 | 17644757 | |
| 244 | Acetylation | TLGIDPPKGILLYGP CCCCCCCCEEEEECC | 65.06 | 24489116 | |
| 256 | Ubiquitination | YGPPGTGKTLCARAV ECCCCCCHHHHHHHH | 37.86 | 24961812 | |
| 282 | Ubiquitination | IGSELVQKYVGEGAR HCHHHHHHHHHHHHH | 34.13 | 23749301 | |
| 282 | Acetylation | IGSELVQKYVGEGAR HCHHHHHHHHHHHHH | 34.13 | 24489116 | |
| 301 | Ubiquitination | LFEMARTKKACIIFF HHHHHHHCCEEEEEE | 32.59 | 17644757 | |
| 302 | Ubiquitination | FEMARTKKACIIFFD HHHHHHCCEEEEEEC | 48.13 | 17644757 | |
| 350 | Ubiquitination | FDPRGNIKVMFATNR CCCCCCEEEEEECCC | 31.48 | 17644757 | |
| 374 | Ubiquitination | RPGRIDRKVEFSLPD CCCCCCEEEEEECCC | 42.22 | 23749301 | |
| 394 | Ubiquitination | NIFRIHSKSMSVERG EEEEEECCCCCHHHC | 35.70 | 23749301 | |
| 415 | Phosphorylation | SRLCPNSTGAELRSV HHHCCCCCCHHHHHH | 47.23 | 27017623 | |
| 436 | Ubiquitination | FAIRARRKVATEKDF HHHHHHCCCCCHHHH | 30.57 | 22817900 | |
| 441 | Ubiquitination | RRKVATEKDFLKAVD HCCCCCHHHHHHHHH | 49.80 | 23749301 | |
| 441 | Acetylation | RRKVATEKDFLKAVD HCCCCCHHHHHHHHH | 49.80 | 24489116 | |
| 445 | Ubiquitination | ATEKDFLKAVDKVIS CCHHHHHHHHHHHHH | 46.48 | 22817900 | |
| 445 | Acetylation | ATEKDFLKAVDKVIS CCHHHHHHHHHHHHH | 46.48 | 24489116 | |
| 449 | Ubiquitination | DFLKAVDKVISGYKK HHHHHHHHHHHCCCC | 34.56 | 23749301 | |
| 455 | Ubiquitination | DKVISGYKKFSSTSR HHHHHCCCCCCCCCC | 51.36 | 22817900 | |
| 456 | Ubiquitination | KVISGYKKFSSTSRY HHHHCCCCCCCCCCC | 41.83 | 22817900 | |
| 456 | Acetylation | KVISGYKKFSSTSRY HHHHCCCCCCCCCCC | 41.83 | 25381059 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PRS7_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PRS7_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PRS7_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164 AND SER-231, ANDMASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164, AND MASSSPECTROMETRY. | |
