CSR2_YEAST - dbPTM
CSR2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CSR2_YEAST
UniProt AC Q12734
Protein Name Transcription factor CSR2
Gene Name CSR2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1121
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Transcription factor involved in the regulation of fermentation and aerobic oxidation. Acts as a repressor of CYC1, which is involved in electron flow through the mitochondria under aerobic condition. Required for pseudohyphal formation upon nitrogen starvation. May be involved in viability at stationary phase and aging..
Protein Sequence MQSTVPIAIASNGNKRDVVQNVSAGDEGDILQRLARNREMISTSLSPQKSSGFSGRRRSSSVRDALSSFFGTGNSPTSSMDDYSNLMNRNYSTASTAMCRGNSFPSDVGTKAYNITGSYQPDRHRNSVPYTTIDQLHTRQDTGLRRESDPVAAKQISSNNDIVRSFITHHASNSTMFINRVLSDYLADRGFIKQTPLYNKKSVLEISIATSAESVFLPTTKSDETEYLSLIHGSLNQARTQPVGSTNTAESDFLPSCPTMDTLNENNDLSLFPLHTQRTSPSNTARTGNAMDTSNSDRASPASNNNTTDADSFVASGNNNPMNNNNSPARNRHPNSHSRSLPNAWNSQMPSFSFALIFSLNKSTTLSDIKVELTSNVRVVWFNGLPPTKNVNEECYNIGSLDWTLNADNFNLFIPQGAKSPLDIVENHSNNRKLKVLQKLSMRKRRSFSNKAVLRENILNNLNASNSTNKLNAGVYVFTIPIVLASRIPESLYYPSARVSYSLRLATKLKDEHTQLVASRPRSSSISSPQKLRSYSCSDSYEYSQIDDTIEGETYNNDKNSTGKIAFPSSWLKSAKGRLKRNNSNGRSDNNGASSSGLAMQHDSEDTINLQYPLNLVRTPPEISVTTANKPLYINKVWENCLSYEISFAQKYVPLNGEIPITIKVAPLVKSLSVKRIRVSCREKISYRSKDYQYDFDQLDPLASDPCNPYHMRYLVRKKKDRSLPLFEVASKCTSGPSIREEVVTNTVDDNLLAYTSSKENNKDIPFSESFTVKTKLKFPKYCEVDATKAASLPPYGIDLFDPIKDPTQSENTSNNGNVLGFLVGRPNRASKTVHKIPQDKNHNEVNDTNGNSNTSLQTSSNVPIQHYTRLNKPRRGLYLDSMHFKNIQCSHKLEIVLRVSKTDSGSSKIIRHYEVIVDTPIYLISDLCNTSNIDLPTYDMATTESSKVLPPTFEEATSVSASPRSSVSYYPDDISMQQLNLSRSTSLANGYLSTLHPKTTAVSDSSNGAPIRDQQEQQARPLRTEDYALQMGNENNAYSNMDGLLSQDIFEQETAATLFKRDIVTMNFNNNIFTPRYSPRTFTNTDYNYNDNDNNDNDTEGPGPIIHPGPEPPRYDEISS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
23PhosphorylationRDVVQNVSAGDEGDI
CCEEECCCCCCHHHH		33.8028152593
42PhosphorylationARNREMISTSLSPQK
HHCHHHHEECCCCCC		15.6128889911
43PhosphorylationRNREMISTSLSPQKS
HCHHHHEECCCCCCC		23.8219779198
44PhosphorylationNREMISTSLSPQKSS
CHHHHEECCCCCCCC		21.7623749301
46PhosphorylationEMISTSLSPQKSSGF
HHHEECCCCCCCCCC		25.6723749301
50PhosphorylationTSLSPQKSSGFSGRR
ECCCCCCCCCCCCCC		30.3719779198
60PhosphorylationFSGRRRSSSVRDALS
CCCCCCCHHHHHHHH		30.9228889911
61PhosphorylationSGRRRSSSVRDALSS
CCCCCCHHHHHHHHH		23.5528889911
67PhosphorylationSSVRDALSSFFGTGN
HHHHHHHHHHHCCCC		27.1627017623
68PhosphorylationSVRDALSSFFGTGNS
HHHHHHHHHHCCCCC		25.9919779198
75PhosphorylationSFFGTGNSPTSSMDD
HHHCCCCCCCCCHHH		30.7928889911
77PhosphorylationFGTGNSPTSSMDDYS
HCCCCCCCCCHHHHH		33.0030377154
79PhosphorylationTGNSPTSSMDDYSNL
CCCCCCCCHHHHHHH		28.8030377154
83PhosphorylationPTSSMDDYSNLMNRN
CCCCHHHHHHHHHCC		8.6627017623
92PhosphorylationNLMNRNYSTASTAMC
HHHHCCCCCCCCCHH		22.5019779198
93PhosphorylationLMNRNYSTASTAMCR
HHHCCCCCCCCCHHC		17.8019779198
95PhosphorylationNRNYSTASTAMCRGN
HCCCCCCCCCHHCCC		19.4530377154
96PhosphorylationRNYSTASTAMCRGNS
CCCCCCCCCHHCCCC		18.8819779198
103PhosphorylationTAMCRGNSFPSDVGT
CCHHCCCCCCCCCCC		41.1622369663
106PhosphorylationCRGNSFPSDVGTKAY
HCCCCCCCCCCCCCE		42.8122369663
110PhosphorylationSFPSDVGTKAYNITG
CCCCCCCCCCEECCC		16.6127017623
113PhosphorylationSDVGTKAYNITGSYQ
CCCCCCCEECCCCCC		14.5127017623
116PhosphorylationGTKAYNITGSYQPDR
CCCCEECCCCCCCCC		19.2119779198
118PhosphorylationKAYNITGSYQPDRHR
CCEECCCCCCCCCCC		16.3727017623
119PhosphorylationAYNITGSYQPDRHRN
CEECCCCCCCCCCCC		25.9619779198
127PhosphorylationQPDRHRNSVPYTTID
CCCCCCCCCCCCCHH		25.1529136822
130PhosphorylationRHRNSVPYTTIDQLH
CCCCCCCCCCHHHHH		17.8529136822
132PhosphorylationRNSVPYTTIDQLHTR
CCCCCCCCHHHHHHC		19.4019779198
142PhosphorylationQLHTRQDTGLRRESD
HHHHCCCCCCCCCCC		29.7628889911
148PhosphorylationDTGLRRESDPVAAKQ
CCCCCCCCCHHHHHH		45.4627214570
157PhosphorylationPVAAKQISSNNDIVR
HHHHHHHCCCCHHHH		25.2329734811
158PhosphorylationVAAKQISSNNDIVRS
HHHHHHCCCCHHHHH		41.0822369663
172PhosphorylationSFITHHASNSTMFIN
HHHHHHCCCCHHHHH		27.2719779198
222PhosphorylationVFLPTTKSDETEYLS
EECCCCCCCCHHHHH		38.2929688323
225PhosphorylationPTTKSDETEYLSLIH
CCCCCCCHHHHHHHC		34.6129688323
227PhosphorylationTKSDETEYLSLIHGS
CCCCCHHHHHHHCCC		14.7129688323
229PhosphorylationSDETEYLSLIHGSLN
CCCHHHHHHHCCCCC		25.1129688323
234PhosphorylationYLSLIHGSLNQARTQ
HHHHHCCCCCCCCCC		15.2429688323
327PhosphorylationNPMNNNNSPARNRHP
CCCCCCCCCCCCCCC		23.2823749301
514PhosphorylationTKLKDEHTQLVASRP
HHCCHHCHHHHHCCC		22.8819823750
519PhosphorylationEHTQLVASRPRSSSI
HCHHHHHCCCCCCCC		35.0219823750
523PhosphorylationLVASRPRSSSISSPQ
HHHCCCCCCCCCCCH		30.9919823750
524PhosphorylationVASRPRSSSISSPQK
HHCCCCCCCCCCCHH		32.7319823750
525PhosphorylationASRPRSSSISSPQKL
HCCCCCCCCCCCHHH		27.9525752575
527PhosphorylationRPRSSSISSPQKLRS
CCCCCCCCCCHHHHC		37.6019823750
528PhosphorylationPRSSSISSPQKLRSY
CCCCCCCCCHHHHCC		29.6727214570
534PhosphorylationSSPQKLRSYSCSDSY
CCCHHHHCCCCCCCC		31.6619779198
541PhosphorylationSYSCSDSYEYSQIDD
CCCCCCCCCCCCCCC		24.7119779198
544PhosphorylationCSDSYEYSQIDDTIE
CCCCCCCCCCCCCEE		14.5519779198
841UbiquitinationVHKIPQDKNHNEVND
EEECCCCCCCCCCCC		55.6612872131
958PhosphorylationPPTFEEATSVSASPR
CCCHHCCCCCCCCCC		32.7029136822
959PhosphorylationPTFEEATSVSASPRS
CCHHCCCCCCCCCCC		22.5629734811
961PhosphorylationFEEATSVSASPRSSV
HHCCCCCCCCCCCCC		23.8529136822
963PhosphorylationEATSVSASPRSSVSY
CCCCCCCCCCCCCCC		17.2229136822
966PhosphorylationSVSASPRSSVSYYPD
CCCCCCCCCCCCCCC		38.1819779198
967PhosphorylationVSASPRSSVSYYPDD
CCCCCCCCCCCCCCC		19.1630377154
969PhosphorylationASPRSSVSYYPDDIS
CCCCCCCCCCCCCCC		22.3928889911
983PhosphorylationSMQQLNLSRSTSLAN
CHHHHCCCCCHHHHC		24.1019779198
985PhosphorylationQQLNLSRSTSLANGY
HHHCCCCCHHHHCCC		20.9722369663
986PhosphorylationQLNLSRSTSLANGYL
HHCCCCCHHHHCCCH		27.0122369663
987PhosphorylationLNLSRSTSLANGYLS
HCCCCCHHHHCCCHH		27.0822369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseRSP5P39940
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CSR2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CSR2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GAL3_YEASTGAL3genetic
12444972
AIM3_YEASTAIM3genetic
21035341
GET2_YEASTGET2genetic
23891562
YAJ8_YEASTYAR028Wgenetic
27708008
RU1A_YEASTMUD1genetic
27708008
YD391_YEASTYDR391Cgenetic
27708008
XRN1_YEASTXRN1genetic
27708008
CWC26_YEASTBUD13genetic
27708008
AIM39_YEASTAIM39genetic
27708008
LDS1_YEASTLDS1genetic
27708008
ERP1_YEASTERP1genetic
27708008
RL23A_YEASTRPL23Agenetic
27708008
RL23B_YEASTRPL23Agenetic
27708008
ADPP_YEASTYSA1genetic
27708008
KTR4_YEASTKTR4genetic
27708008
FTH1_YEASTFTH1genetic
27708008
HPC2_YEASTHPC2genetic
27708008
REI1_YEASTREI1genetic
27708008
RV161_YEASTRVS161genetic
27708008
INO2_YEASTINO2genetic
27708008
SAN1_YEASTSAN1genetic
27708008
RPA14_YEASTRPA14genetic
27708008
YD286_YEASTYDR286Cgenetic
27708008
SDHF3_YEASTSDH7genetic
27708008
PP2C2_YEASTPTC2genetic
27708008
RAD51_YEASTRAD51genetic
27708008
SPR6_YEASTSPR6genetic
27708008
PT122_YEASTPET122genetic
27708008
SPT2_YEASTSPT2genetic
27708008
SA155_YEASTSAP155genetic
27708008
ALK1_YEASTALK1genetic
27708008
MON1_YEASTMON1genetic
27708008
PIL1_YEASTPIL1genetic
27708008
DBF2_YEASTDBF2genetic
27708008
BTN2_YEASTBTN2genetic
27708008
HTD2_YEASTHTD2genetic
27708008
KTR7_YEASTKTR7genetic
27708008
ICE2_YEASTICE2genetic
27708008
THIK_YEASTPOT1genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
RL17B_YEASTRPL17Bgenetic
27708008
REE1_YEASTREE1genetic
27708008
CBF1_YEASTCBF1genetic
27708008
CBT1_YEASTCBT1genetic
27708008
ORN_YEASTREX2genetic
27708008
LAM6_YEASTYLR072Wgenetic
27708008
VPS9_YEASTVPS9genetic
27708008
MLH1_YEASTMLH1genetic
27708008
RAD14_YEASTRAD14genetic
27708008
SKY1_YEASTSKY1genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
HST1_YEASTHST1genetic
27708008
ENB1_YEASTENB1genetic
27708008
BUB3_YEASTBUB3genetic
27708008
VPS5_YEASTVPS5genetic
27708008
YORA4_YEASTYOR114Wgenetic
27708008
OSW1_YEASTOSW1genetic
27708008
RFM1_YEASTRFM1genetic
27708008
BMH1_YEASTBMH1physical
28468835
BMH2_YEASTBMH2physical
28468835
RSP5_YEASTRSP5physical
28468835
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CSR2_YEAST

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Related Literatures of Post-Translational Modification
Ubiquitylation
ReferencePubMed
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: PROTEIN SEQUENCE OF 837-870, UBIQUITINATION [LARGE SCALE ANALYSIS] ATLYS-841, AND MASS SPECTROMETRY.

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