SA155_YEAST - dbPTM
SA155_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SA155_YEAST
UniProt AC P43612
Protein Name SIT4-associating protein SAP155
Gene Name SAP155
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1002
Subcellular Localization Cytoplasm .
Protein Description Positive regulator of protein phosphatase SIT4. Involved in directing expression of TOR-repressed genes and in dephosphorylation of NPR1 in response to nutrient starvation. Negatively modulates K(+) efflux of the cell by the Na(+)-K(+)/H(+) antiporter NHA1..
Protein Sequence MSFWPFGQNLNHSNINKILDEYFHVLHELERINPSVGKAIPAIFNNVQERGTSDSLDSIPEEYSHGDEVKTARGDQKSRFEKDDQQERYEKEEEERSMNSSESSTTSFSSGSTSKTDLDEEDISNATAPMMVTTKNLDNSFIERMLVETELLNELSRQNKTLLDFICFGFFFDKKTNKKVNNMEYLVDQLMECISKIKTATTVDLNNLIDYQEQQQLDDSSQEDVYVESDTEQEEEKEDDNNSNNKKRRKRGSSSFGNDDINNNDDDDDANEDDESAYLTKATIISEIFSLDIWLISESLVKNQSYLNKIWSIINQPNFNSENSPLVPIFLKINQNLLLTRQDQYLNFIRTERSFVDDMLKHVDISLLMDFFLKIISTDKIESPTGIIELVYDQNLISKCLSFLNNKESPADIQACVGDFLKALIAISANAPLDDISIGPNSLTRQLASPESIAKLVDIMINQRGAALNTTVSIVIELIRKNNSDYDQVNLLTTTIKTHPPSNRDPIYLGYLLRKFSNHLSDFFQIILDIENDANIPLHENQLHEKFKPLGFERFKVVELIAELLHCSNMGLMNSKRAERIARRRDKVRSQLSHHLQDALNDLSIEEKEQLKTKHSPTRDTDHDLKNNNGKIDNDNNDNDDESDYGDEIDESFEIPYINMKQNIKLRTDPTVGDLFKIKLYDTRIVSKIMELFLTHPWNNFWHNVIFDIIQQIFNGRMDFSYNSFLVLSLFNLKSSYQFMTDIVISDEKGTDVSRFSPVIRDPNFDFKITTDFILRGYQDSYKFYELRKMNLGYMGHIVLIAEEVVKFSKLYKVELISPDIQVILQTEEWQYYSEEVLNETRMMYSKILGGGSYIDDGNGNIIPQLPDNTTVLTPNGDASNNNEILDSDTGSSNGTSGGGQLINVESLEEQLSLSTESDLHNKLREMLINRAQEDVDNKNTENGVFILGPPEDKNSNSNINNTNHNSNNSNNNDNNDNNDNDNDNTRNYNEDADNDNDYDHE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSFWPFGQN
------CCCCCCCCC		47.5330377154
13PhosphorylationFGQNLNHSNINKILD
CCCCCCCHHHHHHHH		38.0330377154
38UbiquitinationRINPSVGKAIPAIFN
HHCCCHHHHHHHHHH		40.7723749301
52PhosphorylationNNVQERGTSDSLDSI
HCHHHCCCCCCHHCC		35.2722369663
53PhosphorylationNVQERGTSDSLDSIP
CHHHCCCCCCHHCCC		28.2022369663
55PhosphorylationQERGTSDSLDSIPEE
HHCCCCCCHHCCCHH		33.5722369663
58PhosphorylationGTSDSLDSIPEEYSH
CCCCCHHCCCHHHCC		45.3922369663
63PhosphorylationLDSIPEEYSHGDEVK
HHCCCHHHCCCCHHC		12.3322369663
64PhosphorylationDSIPEEYSHGDEVKT
HCCCHHHCCCCHHCC		25.0322369663
70UbiquitinationYSHGDEVKTARGDQK
HCCCCHHCCCCCCCC		34.1323749301
97PhosphorylationEKEEEERSMNSSESS
HHHHHHHHCCCCCCC		26.1221551504
103PhosphorylationRSMNSSESSTTSFSS
HHCCCCCCCCCCCCC		34.6330377154
106PhosphorylationNSSESSTTSFSSGST
CCCCCCCCCCCCCCC		29.7130377154
107PhosphorylationSSESSTTSFSSGSTS
CCCCCCCCCCCCCCC		24.1827017623
113PhosphorylationTSFSSGSTSKTDLDE
CCCCCCCCCCCCCCH		37.4628889911
253PhosphorylationKKRRKRGSSSFGNDD
HHHHHHCCCCCCCCC		27.1723749301
254PhosphorylationKRRKRGSSSFGNDDI
HHHHHCCCCCCCCCC		32.2921440633
255PhosphorylationRRKRGSSSFGNDDIN
HHHHCCCCCCCCCCC		38.5823749301
604PhosphorylationQDALNDLSIEEKEQL
HHHHHCCCHHHHHHH		30.7124961812
613PhosphorylationEEKEQLKTKHSPTRD
HHHHHHCCCCCCCCC		42.4517287358
616PhosphorylationEQLKTKHSPTRDTDH
HHHCCCCCCCCCCCC		29.5317287358
618PhosphorylationLKTKHSPTRDTDHDL
HCCCCCCCCCCCCCC		44.1617287358
643PhosphorylationNNDNDDESDYGDEID
CCCCCCCCCCCCCCC		43.0321440633
645PhosphorylationDNDDESDYGDEIDES
CCCCCCCCCCCCCCC		35.4419795423
652PhosphorylationYGDEIDESFEIPYIN
CCCCCCCCCCCCCCC		25.1619823750
6792-HydroxyisobutyrylationVGDLFKIKLYDTRIV
HHHHEEEEEECHHHH		41.40-
751PhosphorylationVISDEKGTDVSRFSP
EEECCCCCCHHHCCC		44.2721440633
770PhosphorylationPNFDFKITTDFILRG
CCCCEEEECHHHHHC		22.3927017623
781PhosphorylationILRGYQDSYKFYELR
HHHCCCCCCCHHHHH		18.0727017623
782PhosphorylationLRGYQDSYKFYELRK
HHCCCCCCCHHHHHH		17.2627017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SA155_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SA155_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SA155_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PP11_YEASTSIT4physical
11805837
ATG20_YEASTATG20physical
11805837
UTP13_YEASTUTP13physical
11805837
TIP41_YEASTTIP41physical
11805837
SA185_YEASTSAP185genetic
11779790
SA190_YEASTSAP190genetic
11779790
CG13_YEASTCLN3genetic
8649382
SAP4_YEASTSAP4genetic
8649382
TCPZ_YEASTCCT6genetic
15704212
PP11_YEASTSIT4physical
16554755
PPZ2_YEASTPPZ2physical
16554755
ATG18_YEASTATG18physical
16554755
GCN20_YEASTGCN20physical
16429126
THDH_YEASTILV1physical
16429126
MAOM_YEASTMAE1physical
16429126
MPG1_YEASTPSA1physical
16429126
VATA_YEASTVMA1physical
16429126
TBA3_YEASTTUB3physical
16429126
PP11_YEASTSIT4physical
16429126
SWI4_YEASTSWI4genetic
17314980
UBP3_YEASTUBP3genetic
17314980
BEM2_YEASTBEM2genetic
17314980
NUP84_YEASTNUP84genetic
17314980
UME6_YEASTUME6genetic
17314980
BUD27_YEASTBUD27genetic
17314980
PAF1_YEASTPAF1genetic
17314980
RAD3_YEASTRAD3genetic
17314980
LSM6_YEASTLSM6genetic
17314980
GET2_YEASTGET2genetic
17314980
UBC4_YEASTUBC4genetic
17314980
H4_YEASTHHF1genetic
17314980
RGP1_YEASTRGP1genetic
17314980
TCPQ_YEASTCCT8genetic
15704212
PUR92_YEASTADE17physical
18467557
TIP41_YEASTTIP41physical
18467557
TPS1_YEASTTPS1genetic
19269370
CKS1_YEASTCKS1genetic
19269370
OCA6_YEASTOCA6genetic
19269370
NBP2_YEASTNBP2genetic
19269370
LCMT1_YEASTPPM1genetic
19269370
SWI4_YEASTSWI4genetic
19269370
UBP3_YEASTUBP3genetic
19269370
AAKG_YEASTSNF4genetic
19269370
SAP4_YEASTSAP4genetic
19269370
OCA5_YEASTOCA5genetic
19269370
PTPA1_YEASTRRD1genetic
19269370
RPA34_YEASTRPA34genetic
19269370
MNN11_YEASTMNN11genetic
19269370
ADK_YEASTADO1genetic
19269370
RIC1_YEASTRIC1genetic
19269370
YPT6_YEASTYPT6genetic
19269370
VIP1_YEASTVIP1genetic
19269370
SIW14_YEASTSIW14genetic
19269370
LSM7_YEASTLSM7genetic
19269370
BRE5_YEASTBRE5genetic
19269370
PHO80_YEASTPHO80genetic
19269370
2A5D_YEASTRTS1genetic
19269370
ISR1_YEASTISR1genetic
19269370
PP11_YEASTSIT4physical
19749176
PP11_YEASTSIT4genetic
19749176
SAP4_YEASTSAP4genetic
19749176
SA185_YEASTSAP185genetic
19749176
PP11_YEASTSIT4physical
17846631
TIP41_YEASTTIP41physical
17846631
PIN4_YEASTPIN4genetic
15704212
SDS23_YEASTSDS23genetic
15704212
YAK1_YEASTYAK1genetic
15704212
NUF2_YEASTNUF2physical
20489023
PP11_YEASTSIT4physical
20489023
TIP41_YEASTTIP41physical
20489023
PUR92_YEASTADE17physical
22615397
CDC20_YEASTCDC20genetic
27708008
BIG1_YEASTBIG1genetic
27708008
DIB1_YEASTDIB1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
CDC24_YEASTCDC24genetic
27708008
LSM2_YEASTLSM2genetic
27708008
ERD2_YEASTERD2genetic
27708008
AAR2_YEASTAAR2genetic
27708008
KPC1_YEASTPKC1genetic
27708008
RFC5_YEASTRFC5genetic
27708008
CKS1_YEASTCKS1genetic
27708008
CDK1_YEASTCDC28genetic
27708008
CDC10_YEASTCDC10genetic
27708008
APC11_YEASTAPC11genetic
27708008
SUB2_YEASTSUB2genetic
27708008
UAP1_YEASTQRI1genetic
27708008
KIN28_YEASTKIN28genetic
27708008
TCPD_YEASTCCT4genetic
27708008
NOP14_YEASTNOP14genetic
27708008
MAK21_YEASTMAK21genetic
27708008
PDC2_YEASTPDC2genetic
27708008
TAF12_YEASTTAF12genetic
27708008
SYF1_YEASTSYF1genetic
27708008
GPI17_YEASTGPI17genetic
27708008
PRP3_YEASTPRP3genetic
27708008
TSC11_YEASTTSC11genetic
27708008
TBP_YEASTSPT15genetic
27708008
PTI1_YEASTPTI1genetic
27708008
RRP41_YEASTSKI6genetic
27708008
RPC9_YEASTRPC17genetic
27708008
GRP78_YEASTKAR2genetic
27708008
RFC2_YEASTRFC2genetic
27708008
CDC11_YEASTCDC11genetic
27708008
UGPA1_YEASTUGP1genetic
27708008
PRI2_YEASTPRI2genetic
27708008
CWC16_YEASTYJU2genetic
27708008
TOR2_YEASTTOR2genetic
27708008
RPF2_YEASTRPF2genetic
27708008
SSL1_YEASTSSL1genetic
27708008
NOP56_YEASTNOP56genetic
27708008
TAD3_YEASTTAD3genetic
27708008
TAF8_YEASTTAF8genetic
27708008
SPC24_YEASTSPC24genetic
27708008
RNA1_YEASTRNA1genetic
27708008
PRP24_YEASTPRP24genetic
27708008
DPOA_YEASTPOL1genetic
27708008
MED4_YEASTMED4genetic
27708008
CLP1_YEASTCLP1genetic
27708008
RPA1_YEASTRPA190genetic
27708008
HRR25_YEASTHRR25genetic
27708008
SEC8_YEASTSEC8genetic
27708008
SRP54_YEASTSRP54genetic
27708008
PSB5_YEASTPRE2genetic
27708008
RPN7_YEASTRPN7genetic
27708008
PRP4_YEASTPRP4genetic
27708008
PEX19_YEASTPEX19genetic
27708008
BRE1_YEASTBRE1genetic
27708008
SND1_YEASTYDR186Cgenetic
27708008
H2A1_YEASTHTA1genetic
27708008
PEX5_YEASTPEX5genetic
27708008
LSM6_YEASTLSM6genetic
27708008
UBP3_YEASTUBP3genetic
27708008
PIB2_YEASTPIB2genetic
27708008
PALF_YEASTRIM8genetic
27708008
MED5_YEASTNUT1genetic
27708008
PSA3_YEASTPRE9genetic
27708008
GTR2_YEASTGTR2genetic
27708008
SMI1_YEASTSMI1genetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
PTPA1_YEASTRRD1genetic
27708008
IMPX_YEASTIMP2genetic
27708008
DAL81_YEASTDAL81genetic
27708008
PHO86_YEASTPHO86genetic
27708008
NU133_YEASTNUP133genetic
27708008
FPS1_YEASTFPS1genetic
27708008
SRN2_YEASTSRN2genetic
27708008
NKP2_YEASTNKP2genetic
27708008
MSC1_YEASTMSC1genetic
27708008
NDH1_YEASTNDE1genetic
27708008
RS7B_YEASTRPS7Bgenetic
27708008
LSM7_YEASTLSM7genetic
27708008
BRE5_YEASTBRE5genetic
27708008
PHO80_YEASTPHO80genetic
27708008
PEX15_YEASTPEX15genetic
27708008
KPR5_YEASTPRS5genetic
27708008
HPF1_YEASTHPF1genetic
27708008
ROD1_YEASTROD1genetic
27708008
ASE1_YEASTASE1genetic
27708008
IDH2_YEASTIDH2genetic
27708008
PALA_YEASTRIM20genetic
27708008
RS10A_YEASTRPS10Agenetic
27708008
SSU1_YEASTSSU1genetic
27708008
ATG21_YEASTATG21genetic
27708008
POC4_YEASTPOC4genetic
27708008
OYE3_YEASTOYE3genetic
27708008
YAR1_YEASTYAR1genetic
27708008
MED1_YEASTMED1genetic
27708008
VPS4_YEASTVPS4genetic
27708008
HDA3_YEASTHDA3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SA155_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55 AND SER-58, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-613; SER-616 ANDTHR-618, AND MASS SPECTROMETRY.

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