PRP3_YEAST - dbPTM
PRP3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRP3_YEAST
UniProt AC Q03338
Protein Name U4/U6 small nuclear ribonucleoprotein PRP3
Gene Name PRP3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 469
Subcellular Localization Nucleus.
Protein Description Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome..
Protein Sequence MPPRNTYEKGNPKRQNSPYYKPSFLRREETTNDEEKFQGHGLKTELHSALKSSNLNLIRRTYQTGENPYLSDPHDRGSSSRFNRRYERGLKFYQKGEISKRIAQERTLQKQQEEEELKRKLKQEEDEKDKRKLIESGDLPNLELHEDKFLLDLSKFKIYYDNNHGYEWWDTAYLDEKGELMEKYDMNGTSPAEEKLAEDIDEVDDDDDDEHPSIRYVAHPLPEKINEAKVSIKAYLTQHERKRLRRNRRKMAREAREIKIKLGLLPKPEPKVKLSNMMSVFENDQNITDPTAWEKVVKDQVDLRKRKHLEENERRHEDAIKRRKEAVNMNVEKPTVYHCKVFQFKNLQNPKIRFKLKMNSKELSLKGLCLRIRDDGPGIIIVVGNEKSCKFYENLVMKRIKWNEDFELHTNTGDIKMDMHNNSISKTWEGYLQDCKFKGWFMKVCNDQDSLLRTLGQFDSEHFYSPVQT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9AcetylationPPRNTYEKGNPKRQN
CCCCCCCCCCCCCCC		54.2825381059
17PhosphorylationGNPKRQNSPYYKPSF
CCCCCCCCCCCCHHH		13.1229136822
19PhosphorylationPKRQNSPYYKPSFLR
CCCCCCCCCCHHHHC		24.7629136822
23PhosphorylationNSPYYKPSFLRREET
CCCCCCHHHHCCCCC		32.5317287358
30PhosphorylationSFLRREETTNDEEKF
HHHCCCCCCCHHHHH		26.5820377248
31PhosphorylationFLRREETTNDEEKFQ
HHCCCCCCCHHHHHC		43.9128889911
43AcetylationKFQGHGLKTELHSAL
HHCCCCHHHHHHHHH		44.5425381059
51AcetylationTELHSALKSSNLNLI
HHHHHHHHHCCCHHH		52.1022865919
71PhosphorylationTGENPYLSDPHDRGS
CCCCCCCCCCCCCCC		43.1628889911
91AcetylationRRYERGLKFYQKGEI
HHHHHHCCHHHHCHH		44.8625381059
184PhosphorylationKGELMEKYDMNGTSP
CCCCHHHCCCCCCCH		13.7122369663
189PhosphorylationEKYDMNGTSPAEEKL
HHCCCCCCCHHHHHH		26.9122369663
190PhosphorylationKYDMNGTSPAEEKLA
HCCCCCCCHHHHHHH		24.4222369663
235PhosphorylationAKVSIKAYLTQHERK
HHHHHHHHHHHHHHH		12.7919684113
237PhosphorylationVSIKAYLTQHERKRL
HHHHHHHHHHHHHHH		18.4019684113
298AcetylationTAWEKVVKDQVDLRK
CHHHHHHHHHHHHHH		45.4925381059
360PhosphorylationRFKLKMNSKELSLKG
EEEEEECCEEEEECE		24.8225882841
450PhosphorylationKVCNDQDSLLRTLGQ
HHHCCHHHHHHHHCC		24.5427214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRP3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRP3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRP3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PRP4_YEASTPRP4physical
14759368
PRP6_YEASTPRP6physical
14759368
SN114_YEASTSNU114physical
14759368
STT4_YEASTSTT4physical
14759368
PRP4_YEASTPRP4physical
11283351
PRP4_YEASTPRP4physical
9826507
PRP3_YEASTPRP3physical
9826507
PRP3_YEASTPRP3physical
10696880
SPP41_YEASTSPP41genetic
8005438
REG1_YEASTREG1genetic
8005438
PRP31_YEASTPRP31physical
16554755
BRR2_YEASTBRR2physical
16429126
DIB1_YEASTDIB1physical
16429126
PRP31_YEASTPRP31physical
16429126
PRP38_YEASTPRP38physical
16429126
PRP4_YEASTPRP4physical
16429126
PRP6_YEASTPRP6physical
16429126
PRP8_YEASTPRP8physical
16429126
RSMB_YEASTSMB1physical
16429126
SMD1_YEASTSMD1physical
16429126
SMD2_YEASTSMD2physical
16429126
SMD3_YEASTSMD3physical
16429126
SN114_YEASTSNU114physical
16429126
SNU23_YEASTSNU23physical
16429126
SNU66_YEASTSNU66physical
16429126
SP381_YEASTSPP381physical
16429126
LSM2_YEASTLSM2physical
16429126
LSM6_YEASTLSM6physical
16429126
ATG17_YEASTATG17physical
11283351
LRS4_YEASTLRS4genetic
19061648
RT103_YEASTRTT103genetic
19061648
ATG17_YEASTATG17physical
18719252
URE2_YEASTURE2physical
18719252
PBP2_YEASTPBP2physical
18719252
LSP1_YEASTLSP1physical
18719252
PRP4_YEASTPRP4physical
18719252
MCM2_YEASTMCM2physical
18719252
FHL1_YEASTFHL1genetic
8005438
PRP4_YEASTPRP4genetic
8005438
MRN1_YEASTMRN1genetic
23028530
RS17A_YEASTRPS17Aphysical
27244240
BRR2_YEASTBRR2physical
27244240
SN114_YEASTSNU114physical
27244240
ASK10_YEASTASK10genetic
27708008
ERG3_YEASTERG3genetic
27708008
ACE2_YEASTACE2genetic
27708008
LSM2_YEASTLSM2genetic
27708008
AAR2_YEASTAAR2genetic
27708008
KPC1_YEASTPKC1genetic
27708008
PRP6_YEASTPRP6genetic
27708008
TFC1_YEASTTFC1genetic
27708008
KRR1_YEASTKRR1genetic
27708008
RPN5_YEASTRPN5genetic
27708008
SAD1_YEASTSAD1genetic
27708008
PRP18_YEASTPRP18genetic
27708008
SMD1_YEASTSMD1genetic
27708008
PRP31_YEASTPRP31genetic
27708008
ORC6_YEASTORC6genetic
27708008
DPB11_YEASTDPB11genetic
27708008
CWC16_YEASTYJU2genetic
27708008
SN114_YEASTSNU114genetic
27708008
MED14_YEASTRGR1genetic
27708008
BOS1_YEASTBOS1genetic
27708008
CLF1_YEASTCLF1genetic
27708008
RU1C_YEASTYHC1genetic
27708008
POB3_YEASTPOB3genetic
27708008
RSC9_YEASTRSC9genetic
27708008
PRP24_YEASTPRP24genetic
27708008
GPI12_YEASTGPI12genetic
27708008
SEC12_YEASTSEC12genetic
27708008
RPC1_YEASTRPO31genetic
27708008
ARP7_YEASTARP7genetic
27708008
RDS3_YEASTRDS3genetic
27708008
PRP4_YEASTPRP4genetic
27708008
SWC3_YEASTSWC3genetic
27708008
ISW1_YEASTISW1genetic
27708008
RS14A_YEASTRPS14Agenetic
27708008
NHP10_YEASTNHP10genetic
27708008
GPR1_YEASTGPR1genetic
27708008
LHP1_YEASTLHP1genetic
27708008
ATG9_YEASTATG9genetic
27708008
MSH4_YEASTMSH4genetic
27708008
GCN20_YEASTGCN20genetic
27708008
PUF4_YEASTPUF4genetic
27708008
KA122_YEASTKAP122genetic
27708008
CWC26_YEASTBUD13genetic
27708008
GCN1_YEASTGCN1genetic
27708008
MDS3_YEASTMDS3genetic
27708008
PFD3_YEASTPAC10genetic
27708008
TBP7_YEASTYTA7genetic
27708008
REXO1_YEASTRNH70genetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
FSH1_YEASTFSH1genetic
27708008
LIN1_YEASTLIN1genetic
27708008
RE104_YEASTREC104genetic
27708008
IST3_YEASTIST3genetic
27708008
LPLA_YEASTAIM22genetic
27708008
LSM1_YEASTLSM1genetic
27708008
RS21B_YEASTRPS21Bgenetic
27708008
RPA34_YEASTRPA34genetic
27708008
ISY1_YEASTISY1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
FABG_YEASTOAR1genetic
27708008
CTK1_YEASTCTK1genetic
27708008
YRA2_YEASTYRA2genetic
27708008
VPS71_YEASTVPS71genetic
27708008
ERG2_YEASTERG2genetic
27708008
ZRC1_YEASTZRC1genetic
27708008
TMA23_YEASTTMA23genetic
27708008
PUB1_YEASTPUB1genetic
27708008
OCA2_YEASTOCA2genetic
27708008
TOM7_YEASTTOM7genetic
27708008
RAS2_YEASTRAS2genetic
27708008
LSM7_YEASTLSM7genetic
27708008
PFD4_YEASTGIM3genetic
27708008
VPS27_YEASTVPS27genetic
27708008
FYV12_YEASTFYV12genetic
27708008
SNU66_YEASTSNU66genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
TGS1_YEASTTGS1genetic
27708008
WDR6_YEASTRTT10genetic
27708008
BRR1_YEASTBRR1genetic
27708008
HDA3_YEASTHDA3genetic
27708008
DVL2_HUMANDVL2physical
27107014
CEP44_HUMANCEP44physical
27107014
IKZF1_HUMANIKZF1physical
27107014
CEP70_HUMANCEP70physical
27107014
ZBT8A_HUMANZBTB8Aphysical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRP3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71 AND SER-190, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, AND MASSSPECTROMETRY.

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