| UniProt ID | GCN1_YEAST | |
|---|---|---|
| UniProt AC | P33892 | |
| Protein Name | eIF-2-alpha kinase activator GCN1 {ECO:0000305} | |
| Gene Name | GCN1 {ECO:0000312|SGD:S000003163} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 2672 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Acts as a positive activator of the GCN2 protein kinase activity in response to amino acid starvation. [PubMed: 8497269] | |
| Protein Sequence | MTAILNWEDISPVLEKGTRESHVSKRVPFLQDISQLVRQETLEKPQLSEIAFVLLNTFTIYEDNRSKSLVTSILLDILNLEPCLLENFIRFISDVVISNPATKAVADYLNLLDWINSFLIFVSHNSNLFEEYIPKLLVAHSYATFGVETILDNQEEGKKSQDKQNQHRKRIRYCIFQTTVKAFLKCLKDNDDSISFMKISIKTVLESYSKLKITSVGVVMIMGALTQAALQLLSRQPALHSVLKENSAEKYCEYLGKEVFLGKNPPSSFCLEIGLKPFLKEFVSQELFIKFFIPNIEKAVLRSPEVGFSILSELYAGVSPEKVNLLNAFASSKLINQYFSSFKSSKEVVRSVSLQSMIILLRKISNTDTTLEDLTKLIDEIFKNIKSNLNADYKSLISKILIEIPLTHYEVSEKICKGLSPYIGKEGNEAALTLMLNAFFVHYFSLGKPIEDLDKIISAGFADKKPALKKCWFAAFLNNSNAASEEVILNFIDGCLEFVKDSIIHYQTHGHACILASIEFTNKILALDNTELNDRVMQLIETLPENSSIGDAILTAALSTELSIENRIHAVNLLQELFYKKPEFIGFSVIDAIERRMRVQELIPQQNTSFKYVTSVLLAITSELPDKEASIKVLINALVIAQWNIFNIKNGWAGLVLRARLDPAEVVKEHASVIMEKILEITGSCEWIDTIYGACGLQAAAYAAFIQPNEFTPILCKTIEADLTADDFSRLSEEDFEIFAGEEGVLVVDVLEESMNKKLSNKNSKEYETLMWEQKIRKEQAKKNVKKLSKEEQELVNEQLAKESAVRSHVSEISTRLKRGIRLVSELSKAACLVQNGIATWFPLAVTKLLYLCSEPNISKLTEDVNNVFLQLSQNVSERLGNIRLFLGLATLRVHNANGISQDYLQEPLVELLTRVLFRIKFVSNQAAIDSISLTYILPLLINVLEKGKAIALKNADKPVVKAEFVEEDEEEEHLLLAMEIISVHAEAFEDPSIPRISIVEVLLSLLSLPSKAKIAKDCFNALCQSISVAPNQEDLDMILSNLLSPNQFVRSTILETLDNEFELEPFMKYSPEVFICRFDSDPSNREIADFIWEFNKFVVNDELLKSLFPLFNQDDSGLRLFAANAYAFGAVSLFTSEENSSKDYLNDLLNFYKEKAKPLEPILDQFGLVLVSASEQKDPWQGRSTVAITLKIMAKAFSAEDDTVVNIIKFLVDDGGLVDREPIVRQEMKEAGVELITLHGSQNSKDLIPIFEEALSSSTDSALKENVIILYGTLARHLQQSDARIHTIIERLLSTLDTPSADIQQAVSACIAPLVFQFKQKVGDYLGILMEKLLNPTVASSMRKGAAWGIAGLVKGYGISALSEFDIIRNLIEAAEDKKEPKRRESVGFCFQYLSESLGKFFEPYVIEILPNILKNLGDAVPEVRDATARATKAIMAHTTGYGVKKLIPVAVSNLDEIAWRTKRGSVQLLGNMAYLDPTQLSASLSTIVPEIVGVLNDSHKEVRKAADESLKRFGEVIRNPEIQKLVPVLLQAIGDPTKYTEEALDSLIQTQFVHYIDGPSLALIIHIIHRGMHDRSANIKRKACKIVGNMAILVDTKDLIPYLQQLIDEVEIAMVDPVPNTRATAARALGALVERLGEEQFPDLIPRLLDTLSDESKSGDRLGSAQALAEVISGLGLTKLDEMLPTILAGVTNFRAYIREGFMPLLLFLPVCFGSQFAPYINQIIQPILSGLADNDENIRDTALKAGKLIVKNYATKAVDLLLPELERGMFDENDRIRLSSVQLTGELLFQVTGISSRNEFSEEDGDHNGEFSGKLVDVLGQDRRDRILAALFVCRNDTSGIVRATTVDIWKALVPNTPRAVKEILPTLTGMIVTHLASSSNVLRNIAAQTLGDLVRRVGGNALSQLLPSLEESLIETSNSDSRQGVCIALYELIESASTETISQFQSTIVNIIRTALIDESATVREAAALSFDVFQDVVGKTAVDEVLPYLLHMLESSDNSDFALLGLQEIMSKKSDVIFPILIPTLLAPPIDAFRASALGSLAEVAGSALYKRLSIIINALVDAIIGTSEDESTKGALELALDRVFLSVNDDEGLHPLLQQIMSLLKSDNIEKRIAVLERLPNFFDKTVLDFDVYIPNFVSHAILSLDDEDQRVVNGNFNALSTLLKKVDKPTLEKLVKPAKQSLALTGRQGQDVAAFKLPRGPNCVLPIFLHGLMYGSNDEREESALAIADVVSKTPAANLKPFVSVITGPLIRVVGERFSSDIKAAILFALNVLFIKIPMFLRPFIPQLQRTFVKSLSDATNETLRLRAAKALGALIEHQPRVDPLVIELVTGAKQATDEGVKTAMLKALLEVIMKAGSKLNENSKTNIVNLVEEEMLGSNDKLAVAYAKLIGSLSEILSNDEAHKILQDKVLNADLDGETGKFAILTLNSFLKDAPTHIFNTGLIDEFVSYILNAIRSPDVYFGENGTIAAGKLLLLEGEKRSPFVKKDAAEPFKIGDENINLLINELSKAVLQPASNSTDVRRLALVVIRTLARFKFDECIKQYFDVVGPSVFSCLRDPVIPIKLAAEKAYLALFKLVEEDDMHTFNEWFAKISDRGNSIETVTGTTIQLRSVGDYTKRVGKRLANVERERIAAGGDAETMFSDRFEDEREIWAVGGVELTTDI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 25 | Ubiquitination | TRESHVSKRVPFLQD CCHHHHHCCCCHHHH | 57.22 | 17644757 | |
| 210 | Acetylation | TVLESYSKLKITSVG HHHHHHHCCCCCCHH | 45.63 | 24489116 | |
| 241 | Phosphorylation | SRQPALHSVLKENSA HCCHHHHHHHHHCCH | 29.96 | 28889911 | |
| 257 | Acetylation | KYCEYLGKEVFLGKN HHHHHHCCCHHCCCC | 48.38 | 24489116 | |
| 298 | Acetylation | FFIPNIEKAVLRSPE HHCCCHHHHHHHCCC | 39.74 | 24489116 | |
| 333 | Ubiquitination | LNAFASSKLINQYFS HHHHHHHHHHHHHHH | 51.39 | 17644757 | |
| 343 | Acetylation | NQYFSSFKSSKEVVR HHHHHCCCCCHHHHH | 56.63 | 24489116 | |
| 343 | Ubiquitination | NQYFSSFKSSKEVVR HHHHHCCCCCHHHHH | 56.63 | 17644757 | |
| 383 | Acetylation | KLIDEIFKNIKSNLN HHHHHHHHHHHHHCC | 64.52 | 24489116 | |
| 394 | Acetylation | SNLNADYKSLISKIL HHCCCCHHHHHHHHH | 39.06 | 24489116 | |
| 580 | Ubiquitination | LLQELFYKKPEFIGF HHHHHHCCCCHHCCH | 55.29 | 17644757 | |
| 581 | Ubiquitination | LQELFYKKPEFIGFS HHHHHCCCCHHCCHH | 38.10 | 17644757 | |
| 760 | Phosphorylation | ESMNKKLSNKNSKEY HHHHHHHCCCCHHHH | 55.42 | 19779198 | |
| 764 | Phosphorylation | KKLSNKNSKEYETLM HHHCCCCHHHHHHHH | 28.59 | 28889911 | |
| 765 | Acetylation | KLSNKNSKEYETLMW HHCCCCHHHHHHHHH | 73.95 | 24489116 | |
| 767 | Phosphorylation | SNKNSKEYETLMWEQ CCCCHHHHHHHHHHH | 20.25 | 17330950 | |
| 769 | Phosphorylation | KNSKEYETLMWEQKI CCHHHHHHHHHHHHH | 22.47 | 30377154 | |
| 775 | Acetylation | ETLMWEQKIRKEQAK HHHHHHHHHHHHHHH | 32.72 | 24489116 | |
| 786 | Ubiquitination | EQAKKNVKKLSKEEQ HHHHHHHHHCCHHHH | 58.34 | 17644757 | |
| 787 | Ubiquitination | QAKKNVKKLSKEEQE HHHHHHHHCCHHHHH | 54.43 | 17644757 | |
| 787 | Acetylation | QAKKNVKKLSKEEQE HHHHHHHHCCHHHHH | 54.43 | 24489116 | |
| 790 | Ubiquitination | KNVKKLSKEEQELVN HHHHHCCHHHHHHHH | 75.58 | 17644757 | |
| 790 | Acetylation | KNVKKLSKEEQELVN HHHHHCCHHHHHHHH | 75.58 | 24489116 | |
| 802 | Ubiquitination | LVNEQLAKESAVRSH HHHHHHHHHHHHHHH | 61.87 | 23749301 | |
| 829 | Ubiquitination | RLVSELSKAACLVQN HHHHHHHHHHHHHHC | 53.26 | 17644757 | |
| 848 | Ubiquitination | WFPLAVTKLLYLCSE HHHHHHHHHHHHHCC | 29.87 | 17644757 | |
| 1081 | Phosphorylation | VFICRFDSDPSNREI EEEEECCCCCCCHHH | 49.02 | 27017623 | |
| 1156 | Ubiquitination | LLNFYKEKAKPLEPI HHHHHHHHCCCCHHH | 58.52 | 17644757 | |
| 1158 | Ubiquitination | NFYKEKAKPLEPILD HHHHHHCCCCHHHHH | 62.29 | 17644757 | |
| 1178 | Ubiquitination | LVSASEQKDPWQGRS EEECCCCCCCCCCCC | 62.80 | 17644757 | |
| 1326 | Phosphorylation | FKQKVGDYLGILMEK HHHHHHHHHHHHHHH | 10.82 | 19795423 | |
| 1345 | Ubiquitination | TVASSMRKGAAWGIA HHHHHHHCCHHHHHH | 44.23 | 17644757 | |
| 1356 | Ubiquitination | WGIAGLVKGYGISAL HHHHHHHHCCCCHHH | 52.00 | 17644757 | |
| 1379 | Acetylation | LIEAAEDKKEPKRRE HHHHHHHCCCCCHHH | 51.01 | 24489116 | |
| 1380 | Acetylation | IEAAEDKKEPKRRES HHHHHHCCCCCHHHH | 86.02 | 24489116 | |
| 1446 | Methylation | HTTGYGVKKLIPVAV HCCCCCHHHHHHHHH | 37.18 | 20137074 | |
| 1446 | Ubiquitination | HTTGYGVKKLIPVAV HCCCCCHHHHHHHHH | 37.18 | 17644757 | |
| 1447 | Ubiquitination | TTGYGVKKLIPVAVS CCCCCHHHHHHHHHC | 49.60 | 17644757 | |
| 1526 | Acetylation | IRNPEIQKLVPVLLQ HCCHHHHHHHHHHHH | 58.05 | 24489116 | |
| 1598 | Phosphorylation | NMAILVDTKDLIPYL CEEEEECHHHHHHHH | 20.98 | 22369663 | |
| 1659 | Ubiquitination | DTLSDESKSGDRLGS HHCCCCCCCCCCCHH | 57.31 | 23749301 | |
| 1659 | Acetylation | DTLSDESKSGDRLGS HHCCCCCCCCCCCHH | 57.31 | 24489116 | |
| 1759 | Acetylation | IVKNYATKAVDLLLP HHHHHHHHHHHHHHH | 37.94 | 24489116 | |
| 1854 | Acetylation | ATTVDIWKALVPNTP EEEHHHHHHHCCCCH | 31.98 | 24489116 | |
| 2056 | Acetylation | VAGSALYKRLSIIIN HHHHHHHHHHHHHHH | 47.95 | 24489116 | |
| 2056 | Ubiquitination | VAGSALYKRLSIIIN HHHHHHHHHHHHHHH | 47.95 | 24961812 | |
| 2131 | Ubiquitination | RLPNFFDKTVLDFDV HCCCCCCCCCCEEEE | 35.06 | 17644757 | |
| 2171 | Acetylation | NALSTLLKKVDKPTL HHHHHHHHHCCCCHH | 54.59 | 24489116 | |
| 2203 | Acetylation | GQDVAAFKLPRGPNC CCCEEEEECCCCCCC | 53.51 | 24489116 | |
| 2247 | Acetylation | KTPAANLKPFVSVIT CCCCHHCCCCEEHHC | 35.90 | 24489116 | |
| 2301 | Acetylation | QLQRTFVKSLSDATN HHHHHHHHHHHHHCH | 41.30 | 24489116 | |
| 2317 | Ubiquitination | TLRLRAAKALGALIE HHHHHHHHHHHHHHH | 43.06 | 17644757 | |
| 2412 | Acetylation | LSNDEAHKILQDKVL HCCHHHHHHHHHHHH | 52.76 | 24489116 | |
| 2480 | Ubiquitination | NGTIAAGKLLLLEGE CCEEECCCEEEECCC | 31.10 | 19722269 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GCN1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GCN1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GCN1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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