PUS7_YEAST - dbPTM
PUS7_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PUS7_YEAST
UniProt AC Q08647
Protein Name Multisubstrate pseudouridine synthase 7
Gene Name PUS7
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 676
Subcellular Localization Nucleus . Cytoplasm . Predominantly nuclear in 30 degrees Celsius and primarily cytoplasmic in heat shock.
Protein Description Catalyzes pseudouridylation at position 35 in U2 snRNA stem-loop II region which induces particular conformation of the mRNA-U2 snRNA duplex and places the nucleophile in an accessible position for the first step of splicing. [PubMed: 12426583]
Protein Sequence MSDSSEATVKRPLDAHVGPSENAAKKLKIEQRTQADGIHEADVGITLFLSPELPGFRGQIKQRYTDFLVNEIDQEGKVIHLTDKGFKMPKKPQRSKEEVNAEKESEAARRQEFNVDPELRNQLVEIFGEEDVLKIESVYRTANKMETAKNFEDKSVRTKIHQLLREAFKNELESVTTDTNTFKIARSNRNSRTNKQEKINQTRDANGVENWGYGPSKDFIHFTLHKENKDTMEAVNVITKLLRVPSRVIRYAGTKDRRAVTCQRVSISKIGLDRLNALNRTLKGMIIGNYNFSDASLNLGDLKGNEFVVVIRDVTTGNSEVSLEEIVSNGCKSLSENGFINYFGMQRFGTFSISTHTIGRELLLSNWKKAAELILSDQDNVLPKSKEARKIWAETKDAALALKQMPRQCLAENALLYSLSNQRKEEDGTYSENAYYTAIMKIPRNLRTMYVHAYQSYVWNSIASKRIELHGLKLVVGDLVIDTSEKSPLISGIDDEDFDEDVREAQFIRAKAVTQEDIDSVKYTMEDVVLPSPGFDVLYPSNEELKQLYVDILKADNMDPFNMRRKVRDFSLAGSYRTVIQKPKSLEYRIIHYDDPSQQLVNTDLDILNNTRAKESGQKYMKAKLDRYMPDKGGEKTAVVLKFQLGTSAYATMALRELMKLETSRRGDMCDVKENI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSDSSEATV
------CCCCCCCCC		46.3129136822
2Acetylation------MSDSSEATV
------CCCCCCCCC		46.3122814378
4Phosphorylation----MSDSSEATVKR
----CCCCCCCCCCC		23.8324961812
5Phosphorylation---MSDSSEATVKRP
---CCCCCCCCCCCC		35.9229136822
8PhosphorylationMSDSSEATVKRPLDA
CCCCCCCCCCCCCCC		23.6224961812
10AcetylationDSSEATVKRPLDAHV
CCCCCCCCCCCCCCC		43.9024489116
20PhosphorylationLDAHVGPSENAAKKL
CCCCCCCCHHHHHHC		37.2422369663
25AcetylationGPSENAAKKLKIEQR
CCCHHHHHHCCHHHH		57.1122865919
84AcetylationKVIHLTDKGFKMPKK
CEEEECCCCCCCCCC		62.1024489116
87AcetylationHLTDKGFKMPKKPQR
EECCCCCCCCCCCCC		64.0624489116
169AcetylationQLLREAFKNELESVT
HHHHHHHHHHHHHCC		57.4724489116
174PhosphorylationAFKNELESVTTDTNT
HHHHHHHHCCCCCCH		37.0730377154
176PhosphorylationKNELESVTTDTNTFK
HHHHHHCCCCCCHHH		28.3830377154
183AcetylationTTDTNTFKIARSNRN
CCCCCHHHHHCCCCC		33.1624489116
229AcetylationFTLHKENKDTMEAVN
EEEECCCCCHHHHHH		56.5224489116
240AcetylationEAVNVITKLLRVPSR
HHHHHHHHHHCCCHH		34.1124489116
269AcetylationCQRVSISKIGLDRLN
EEEEEEHHHCHHHHH		38.8422865919
368SuccinylationELLLSNWKKAAELIL
HHHHCCHHHHHHHHH		36.4623954790
376PhosphorylationKAAELILSDQDNVLP
HHHHHHHCCCCCCCC		26.6522369663
465UbiquitinationVWNSIASKRIELHGL
HHHHHHCCCEEECCC		48.6622817900
487PhosphorylationVIDTSEKSPLISGID
EEECCCCCCCCCCCC		22.3821440633
491PhosphorylationSEKSPLISGIDDEDF
CCCCCCCCCCCHHHC		37.0630377154
582UbiquitinationSYRTVIQKPKSLEYR
CCEEEECCCCCCEEE		43.2023749301
614UbiquitinationILNNTRAKESGQKYM
HHHCCCHHHHHHHHH		49.4719722269
619AcetylationRAKESGQKYMKAKLD
CHHHHHHHHHHHHHH		51.3325381059
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PUS7_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PUS7_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PUS7_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PUS7_YEASTPUS7physical
14759368
IMDH4_YEASTIMD4physical
16429126
TAN1_YEASTTAN1physical
16429126
IMDH3_YEASTIMD3physical
16429126
PABP_YEASTPAB1physical
16429126
MET22_YEASTMET22genetic
18443146
PAP2_YEASTPAP2genetic
18443146
RRP6_YEASTRRP6genetic
18443146
RIC1_YEASTRIC1genetic
19061648
EIF3J_YEASTHCR1genetic
19061648
YPT6_YEASTYPT6genetic
19061648
LSM3_YEASTLSM3genetic
19061648
LRS4_YEASTLRS4genetic
19061648
PUF6_YEASTPUF6genetic
19061648
RS8A_YEASTRPS8Agenetic
19061648
RS8B_YEASTRPS8Agenetic
19061648
ARC1_YEASTARC1genetic
19061648
XPOT_YEASTLOS1genetic
19061648
SNU66_YEASTSNU66genetic
19061648
RU2A_YEASTLEA1genetic
19061648
ELP4_YEASTELP4genetic
19061648
RL19A_YEASTRPL19Bgenetic
27708008
RL19B_YEASTRPL19Bgenetic
27708008
PFD6_YEASTYKE2genetic
27708008
ATC3_YEASTDRS2genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
TREB_YEASTNTH2genetic
27708008
REI1_YEASTREI1genetic
27708008
CSM1_YEASTCSM1genetic
27708008
NHP10_YEASTNHP10genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
GPR1_YEASTGPR1genetic
27708008
ATG9_YEASTATG9genetic
27708008
IES1_YEASTIES1genetic
27708008
RL24A_YEASTRPL24Agenetic
27708008
HNM1_YEASTHNM1genetic
27708008
ITC1_YEASTITC1genetic
27708008
YGP9_YEASTYGL159Wgenetic
27708008
RS25A_YEASTRPS25Agenetic
27708008
PFD3_YEASTPAC10genetic
27708008
ASK10_YEASTASK10genetic
27708008
GTR2_YEASTGTR2genetic
27708008
YG51_YEASTYGR237Cgenetic
27708008
SSF1_YEASTSSF1genetic
27708008
SOL3_YEASTSOL3genetic
27708008
ICE2_YEASTICE2genetic
27708008
PRY1_YEASTPRY1genetic
27708008
SA185_YEASTSAP185genetic
27708008
RS21B_YEASTRPS21Bgenetic
27708008
DPOD3_YEASTPOL32genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
BCH2_YEASTBCH2genetic
27708008
RS21A_YEASTRPS21Agenetic
27708008
POC3_YEASTIRC25genetic
27708008
ALAM_YEASTALT1genetic
27708008
YL287_YEASTYLR287Cgenetic
27708008
AMPD_YEASTAMD1genetic
27708008
CTK3_YEASTCTK3genetic
27708008
SCS7_YEASTSCS7genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
EOS1_YEASTEOS1genetic
27708008
NOP12_YEASTNOP12genetic
27708008
NEW1_YEASTNEW1genetic
27708008
KAR3_YEASTKAR3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PUS7_YEAST

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Related Literatures of Post-Translational Modification

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