BCH2_YEAST - dbPTM
BCH2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BCH2_YEAST
UniProt AC P36122
Protein Name Protein BCH2
Gene Name BCH2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 765
Subcellular Localization Golgi apparatus, trans-Golgi network membrane
Peripheral membrane protein . Trans-Golgi network location requires interaction with CHS5 and with myristoylated GTP-bound ARF1 for the recruitment to the membranes.
Protein Description Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3..
Protein Sequence MSFLWGSTKSKKGKNKKAAGSLPSGVVPQQRVKPTRKNVPIDYPRTLEKVHGESLIFRTSLLSELVSTGKSGIGPPDLIHCTELDKFHDEKIGEFFYITGIDASSVSMPIAFLKLIKWNDGKKLKSASLKNDDITTYCTFNIFQKLDIRLRYESEDVYQVNIVDCLNGNNEIPLSDLIWEETFVSCCIRSVIINSDFERKIPGLVELPFVFENRCASDYKRVIDSLCKFLPRFLECGWDSTKSVYATILNNYLTESLLVFLSITPEFITDYAIQVLDNLMTNDPSNSRYYAIVIISIMERSNDRDVEMIKRIHEILDLLLPVLYGLPSDEPYISDLINCITDVLSIQARFLLNNNDYELSLSISTLATNLSSDNFESWYLLSKGYIFSQQYDKALLSINSMPCLAEYDIVKQAQINAFKFYMNYYKAPLCHSREHCTMTSHELNHLMNIMHYENELELKTIIFGRTVMPNESKYGCIEEIWNKSCLELGPICGPQSDNLINFVSQQEVNTVGDMLLLKRSKETRQESWFIKQVRLLLMELVARIGWNALLQLRSDVFVMESKFKMIESSDKLSTELRQKRLCQRWFDAMFLDVYEDLSISTSSQENKATAKYSGLEWELLGLTLLRVSDLPDAVACLRTSILARFDPISCHHLLNFYLTMDFNDEFMRRFDVDIILDLLVKLISFRIRFYDRFQIFSLQVLRKLEGQLGSEIIKNKIINSPYGQAGITSVIDYMLECLSKNRNEACLAYERPLPDLPSTIKPLAD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMSFLWGSTKSKKGKN
CCCCCCCCCCCCCCC		35.0830377154
46PhosphorylationVPIDYPRTLEKVHGE
CCCCCCCCHHHHCCC		34.4627017623
114UbiquitinationSMPIAFLKLIKWNDG
CCCHHHHHHHHCCCC		41.5322817900
117UbiquitinationIAFLKLIKWNDGKKL
HHHHHHHHCCCCCCC		50.8322817900
504PhosphorylationDNLINFVSQQEVNTV
CCHHHHCCHHHCCCH		23.2428889911
568PhosphorylationSKFKMIESSDKLSTE
HHHHEHHCCCCCCHH		32.6724961812
569PhosphorylationKFKMIESSDKLSTEL
HHHEHHCCCCCCHHH		26.4425752575
573PhosphorylationIESSDKLSTELRQKR
HHCCCCCCHHHHHHH		26.1030377154
649PhosphorylationLARFDPISCHHLLNF
HHHCCCCCHHHHHHE		16.8827017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BCH2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BCH2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BCH2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CHS5_YEASTCHS5physical
16554755
BUD7_YEASTBUD7physical
16498409
CHS6_YEASTCHS6physical
16498409
BCH1_YEASTBCH1physical
16498409
PFD2_YEASTGIM4genetic
20526336
THRC_YEASTTHR4genetic
20526336
LAC1_YEASTLAC1genetic
20526336
VATB_YEASTVMA2genetic
21987634
UBP4_YEASTDOA4genetic
21987634
DOP1_YEASTDOP1genetic
21987634
PEP7_YEASTPEP7genetic
21987634
ODO1_YEASTKGD1genetic
21987634
LAC1_YEASTLAC1genetic
21987634
CDC42_YEASTCDC42genetic
21987634
PFD5_YEASTGIM5genetic
21987634
YTA12_YEASTYTA12genetic
21987634
MAS5_YEASTYDJ1genetic
21987634
AIM44_YEASTAIM44genetic
21987634
BCH2_YEASTBCH2physical
22940862
DAL81_YEASTDAL81genetic
27708008
SWE1_YEASTSWE1genetic
27708008
MDM10_YEASTMDM10genetic
27708008
BUD14_YEASTBUD14genetic
27708008
TPS1_YEASTTPS1genetic
27708008
CCZ1_YEASTCCZ1genetic
27708008
ELO2_YEASTELO2genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
OST4_YEASTOST4genetic
27708008
MNN10_YEASTMNN10genetic
27708008
IPK1_YEASTIPK1genetic
27708008
SEM1_YEASTSEM1genetic
27708008
LSM6_YEASTLSM6genetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
LCMT1_YEASTPPM1genetic
27708008
HAC1_YEASTHAC1genetic
27708008
UBP6_YEASTUBP6genetic
27708008
ERJ5_YEASTERJ5genetic
27708008
SKI8_YEASTSKI8genetic
27708008
ASK10_YEASTASK10genetic
27708008
FHP_YEASTYHB1genetic
27708008
TBP7_YEASTYTA7genetic
27708008
RT107_YEASTRTT107genetic
27708008
ICE2_YEASTICE2genetic
27708008
IF4A_YEASTTIF2genetic
27708008
CYP7_YEASTCPR7genetic
27708008
YJ24_YEASTKCH1genetic
27708008
APE2_YEASTAPE2genetic
27708008
ARP6_YEASTARP6genetic
27708008
ACE2_YEASTACE2genetic
27708008
RFX1_YEASTRFX1genetic
27708008
LIPB_YEASTLIP2genetic
27708008
NKP2_YEASTNKP2genetic
27708008
MRE11_YEASTMRE11genetic
27708008
SIW14_YEASTSIW14genetic
27708008
MKT1_YEASTMKT1genetic
27708008
PHO80_YEASTPHO80genetic
27708008
INO4_YEASTINO4genetic
27708008
SKI7_YEASTSKI7genetic
27708008
DIA2_YEASTDIA2genetic
27708008
SFL1_YEASTSFL1genetic
27708008
RMI1_YEASTRMI1genetic
27708008
RU2A_YEASTLEA1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BCH2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-568 AND SER-569, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-568, AND MASSSPECTROMETRY.

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