| UniProt ID | SKI7_YEAST | |
|---|---|---|
| UniProt AC | Q08491 | |
| Protein Name | Superkiller protein 7 | |
| Gene Name | SKI7 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 747 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Represses the expression of non-poly(A) mRNAs like L-A or M viruses and is therefore involved in antiviral system. Mediates interactions via its N-terminus between the exosome and the SKI complex which operate in the 3'-to-5' mRNA-decay pathway. By interacting with NAM7, is also required for nonsense-mediated 3'-to-5' mRNA-decay (NMD). May recognize a stalled 80S ribosome at the 3'-end of a nonstop mRNA which leads to the recruitment of the exosome and SKI complexes to the mRNAs to be degraded.. | |
| Protein Sequence | MSLLEQLARKRIEKSKGLLSADQSHSTSKSASLLERLHKNRETKDNNAETKRKDLKTLLAKDKVKRSDFTPNQHSVSLSLKLSALKKSNSDLEKQGKSVTLDSKENELPTKRKSPDDKLNLEESWKAIKEMNHYCFLKNDPCINQTDDFAFTNFIIKDKKNSLSTSIPLSSQNSSFLSLKKHNNELLGIFVPCNLPKTTRKVAIENFNRPSPDDIIQSAQLNAFNEKLENLNIKSVPKAEKKEPINLQTPPTESIDIHSFIATHPLNLTCLFLGDTNAGKSTLLGHLLYDLNEISMSSMRELQKKSSNLDPSSSNSFKVILDNTKTERENGFSMFKKVIQVENDLLPPSSTLTLIDTPGSIKYFNKETLNSILTFDPEVYVLVIDCNYDSWEKSLDGPNNQIYEILKVISYLNKNSACKKHLIILLNKADLISWDKHRLEMIQSELNYVLKENFQWTDAEFQFIPCSGLLGSNLNKTENITKSKYKSEFDSINYVPEWYEGPTFFSQLYLLVEHNMNKIETTLEEPFVGTILQSSVLQPIAEINYVSLKVLINSGYIQSGQTIEIHTQYEDFHYYGIVSRMKNSKQILETNTKNNISVGLNPDILEVLVKIHNTEDFTKKQFHIRKGDIIIHSRKTNTLSPNLPNTLKLLALRLIKLSIQTHALSDPVDLGSELLLYHNLTHNAVKLVKILGTNDISINPNQSLIVEVEIIEPDFALNVIDSKYITNNIVLTSIDHKVIAVGRIACQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 29 | Acetylation | DQSHSTSKSASLLER CCCCCCHHHHHHHHH | 50.56 | 24489116 | |
| 88 | Phosphorylation | KLSALKKSNSDLEKQ HHHHHHHCCHHHHHC | 39.72 | 20377248 | |
| 90 | Phosphorylation | SALKKSNSDLEKQGK HHHHHCCHHHHHCCC | 51.14 | 20377248 | |
| 162 | Phosphorylation | IIKDKKNSLSTSIPL EEECCCCCCCCCCCC | 32.35 | 29688323 | |
| 164 | Phosphorylation | KDKKNSLSTSIPLSS ECCCCCCCCCCCCCC | 21.67 | 29688323 | |
| 165 | Phosphorylation | DKKNSLSTSIPLSSQ CCCCCCCCCCCCCCC | 35.65 | 29688323 | |
| 166 | Phosphorylation | KKNSLSTSIPLSSQN CCCCCCCCCCCCCCC | 20.87 | 29688323 | |
| 170 | Phosphorylation | LSTSIPLSSQNSSFL CCCCCCCCCCCCCEE | 25.23 | 27017623 | |
| 171 | Phosphorylation | STSIPLSSQNSSFLS CCCCCCCCCCCCEEE | 40.85 | 29688323 | |
| 174 | Phosphorylation | IPLSSQNSSFLSLKK CCCCCCCCCEEEECC | 18.16 | 27017623 | |
| 175 | Phosphorylation | PLSSQNSSFLSLKKH CCCCCCCCEEEECCC | 37.44 | 29688323 | |
| 178 | Phosphorylation | SQNSSFLSLKKHNNE CCCCCEEEECCCCCE | 35.81 | 27017623 | |
| 306 | Phosphorylation | MRELQKKSSNLDPSS HHHHHHHHCCCCCCC | 31.34 | 30377154 | |
| 307 | Phosphorylation | RELQKKSSNLDPSSS HHHHHHHCCCCCCCC | 50.74 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SKI7_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SKI7_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SKI7_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88 AND SER-90, AND MASSSPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88 AND SER-90, AND MASSSPECTROMETRY. | |
