PDR15_YEAST - dbPTM
PDR15_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PDR15_YEAST
UniProt AC Q04182
Protein Name ATP-dependent permease PDR15
Gene Name PDR15
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1529
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description
Protein Sequence MSSDIRDVEERNSRSSSSSSSSNSAAQSIGQHPYRGFDSEAAERVHELARTLTSQSLLYTANSNNSSSSNHNAHNADSRSVFSTDMEGVNPVFTNPDTPGYNPKLDPNSDQFSSTAWVQNMANICTSDPDFYKPYSLGCVWKNLSASGDSADVSYQSTFANIVPKLLTKGLRLLKPSKEEDTFQILKPMDGCLNPGELLVVLGRPGSGCTTLLKSISSNSHGFKIAKDSIVSYNGLSSSDIRKHYRGEVVYNAESDIHLPHLTVYQTLFTVARMKTPQNRIKGVDREAYANHVTEVAMATYGLSHTRDTKVGNDLVRGVSGGERKRVSIAEVAICGARFQCWDNATRGLDSATALEFIRALKTQADIGKTAATVAIYQCSQDAYDLFDKVCVLDDGYQLYFGPAKDAKKYFQDMGYYCPPRQTTADFLTSITSPTERIISKEFIEKGTRVPQTPKDMAEYWLQSESYKNLIKDIDSTLEKNTDEARNIIRDAHHAKQAKRAPPSSPYVVNYGMQVKYLLIRNFWRMKQSASVTLWQVIGNSVMAFILGSMFYKVMKKNDTSTFYFRGAAMFFAILFNAFSCLLEIFSLYETRPITEKHRTYSLYHPSADAFASVLSEMPPKLITAVCFNIIFYFLVDFRRNGGVFFFYFLINVIATFTLSHLFRCVGSLTKTLQEAMVPASMLLLAISMYTGFAIPKTKILGWSIWIWYINPLAYLFESLMINEFHDRRFPCAQYIPAGPAYQNITGTQRVCSAVGAYPGNDYVLGDDFLKESYDYEHKHKWRGFGIGMAYVVFFFFVYLILCEYNEGAKQKGEMVVFLRSKIKQLKKEGKLQEKHRPGDIENNAGSSPDSATTEKKILDDSSEGSDSSSDNAGLGLSKSEAIFHWRDLCYDVPIKGGQRRILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERVTMGVITGNIFVDGRLRDESFPRSIGYCQQQDLHLKTATVRESLRFSAYLRQPSSVSIEEKNRYVEEVIKILEMQQYSDAVVGVAGEGLNVEQRKRLTIGVELAARPKLLVFLDEPTSGLDSQTAWDTCQLMRKLATHGQAILCTIHQPSAILMQQFDRLLFLQKGGQTVYFGDLGEGCKTMIDYFESKGAHKCPPDANPAEWMLEVVGAAPGSHATQDYNEVWRNSDEYKAVQEELDWMEKNLPGRSKEPTAEEHKPFAASLYYQFKMVTIRLFQQYWRSPDYLWSKFILTIFNQVFIGFTFFKADRSLQGLQNQMLSIFMYTVIFNPILQQYLPSFVQQRDLYEARERPSRTFSWLAFFLSQIIVEIPWNILAGTIAYCIYYYAVGFYANASAAGQLHERGALFWLFSIAFYVYIGSMGLLMISFNEVAETAAHMGTLLFTMALSFCGVMATPKVMPRFWIFMYRVSPLTYMIDALLALGVANVDVKCSNYEMVKFTPPSGTTCGDYMASYIKLAGTGYLSDPSATDICSFCAVSTTNAFLATFSSHYYRRWRNYGIFICYIAFDYIAATFLYWLSRVPKKNGKISEKPKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSDIRDVE
------CCCCCCCHH		48.2822369663
3Phosphorylation-----MSSDIRDVEE
-----CCCCCCCHHH		49.2522369663
60PhosphorylationTSQSLLYTANSNNSS
HHHHHEEECCCCCCC		21.2321440633
63PhosphorylationSLLYTANSNNSSSSN
HHEEECCCCCCCCCC		34.6221440633
69PhosphorylationNSNNSSSSNHNAHNA
CCCCCCCCCCCCCCC		44.0221440633
80PhosphorylationAHNADSRSVFSTDME
CCCCCCCCCCCCCCC		31.3122369663
83PhosphorylationADSRSVFSTDMEGVN
CCCCCCCCCCCCCCC		22.7222369663
84PhosphorylationDSRSVFSTDMEGVNP
CCCCCCCCCCCCCCC		28.0922369663
94PhosphorylationEGVNPVFTNPDTPGY
CCCCCCCCCCCCCCC		46.1822369663
98PhosphorylationPVFTNPDTPGYNPKL
CCCCCCCCCCCCCCC		21.6322369663
101PhosphorylationTNPDTPGYNPKLDPN
CCCCCCCCCCCCCCC		29.5122369663
207PhosphorylationVVLGRPGSGCTTLLK
EEECCCCCCHHHHHH		33.1227017623
217PhosphorylationTTLLKSISSNSHGFK
HHHHHHHHCCCCCEE		30.4727017623
218PhosphorylationTLLKSISSNSHGFKI
HHHHHHHCCCCCEEE		40.4527017623
232PhosphorylationIAKDSIVSYNGLSSS
EECCCEEEECCCCHH		15.9428889911
233PhosphorylationAKDSIVSYNGLSSSD
ECCCEEEECCCCHHH		11.4528889911
238PhosphorylationVSYNGLSSSDIRKHY
EEECCCCHHHHHHHH		36.7528889911
239PhosphorylationSYNGLSSSDIRKHYR
EECCCCHHHHHHHHC		33.4128889911
320PhosphorylationNDLVRGVSGGERKRV
CCCCCCCCCCCCCCE		43.8620377248
351PhosphorylationNATRGLDSATALEFI
CCCCCCCHHHHHHHH		32.3428152593
410PhosphorylationPAKDAKKYFQDMGYY
CHHHHHHHHHHCCCC		13.0321551504
430PhosphorylationTTADFLTSITSPTER
CHHHHHHHCCCCCHH		26.4721551504
432PhosphorylationADFLTSITSPTERII
HHHHHHCCCCCHHCC		28.5521551504
441UbiquitinationPTERIISKEFIEKGT
CCHHCCCHHHHHCCC		46.3523749301
511PhosphorylationSSPYVVNYGMQVKYL
CCCCCCCHHHHHEHH		11.4521440633
558N-linked_GlycosylationFYKVMKKNDTSTFYF
HHHHHHCCCCCCCHH		52.88-
600PhosphorylationPITEKHRTYSLYHPS
CCCHHCCEEECCCCC		19.7228889911
601PhosphorylationITEKHRTYSLYHPSA
CCHHCCEEECCCCCH		9.1628889911
602PhosphorylationTEKHRTYSLYHPSAD
CHHCCEEECCCCCHH		23.1020377248
604PhosphorylationKHRTYSLYHPSADAF
HCCEEECCCCCHHHH		13.0220377248
616PhosphorylationDAFASVLSEMPPKLI
HHHHHHHHCCCHHHH		29.6819779198
744N-linked_GlycosylationPAGPAYQNITGTQRV
CCCCCCCCCCCCHHH		22.55-
851PhosphorylationNAGSSPDSATTEKKI
CCCCCCCCCCCCHHC		30.7921551504
853PhosphorylationGSSPDSATTEKKILD
CCCCCCCCCCHHCCC		39.1725005228
854PhosphorylationSSPDSATTEKKILDD
CCCCCCCCCHHCCCC		45.5925005228
857UbiquitinationDSATTEKKILDDSSE
CCCCCCHHCCCCCCC		42.1223749301
862PhosphorylationEKKILDDSSEGSDSS
CHHCCCCCCCCCCCC		29.9221551504
863PhosphorylationKKILDDSSEGSDSSS
HHCCCCCCCCCCCCC		53.6320377248
866PhosphorylationLDDSSEGSDSSSDNA
CCCCCCCCCCCCCCC		30.2120377248
868PhosphorylationDSSEGSDSSSDNAGL
CCCCCCCCCCCCCCC		33.1820377248
869PhosphorylationSSEGSDSSSDNAGLG
CCCCCCCCCCCCCCC		46.8620377248
870PhosphorylationSEGSDSSSDNAGLGL
CCCCCCCCCCCCCCC		38.5421440633
926UbiquitinationMGASGAGKTTLLDCL
HCCCCCCHHHHHHHH		37.4915699485
1107PhosphorylationQKGGQTVYFGDLGEG
EECCEEEEECCCCCC		12.7721440633
1117PhosphorylationDLGEGCKTMIDYFES
CCCCCHHHHHHHHHH		24.3621440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PDR15_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PDR15_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PDR15_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HSP72_YEASTSSA2physical
22940862
HSP71_YEASTSSA1physical
22940862
SSB1_YEASTSSB1physical
22940862
AIM41_YEASTAIM41physical
23831759
PTR2_YEASTPTR2physical
23831759
ZRT1_YEASTZRT1physical
23831759
ZRT1_YEASTZRT1genetic
23831759
OST2_YEASTOST2physical
23831759
SNF5_YEASTSNF5genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
PEF1_YEASTPEF1genetic
27708008
LDB18_YEASTLDB18genetic
27708008
NKP2_YEASTNKP2genetic
27708008
SAM37_YEASTSAM37genetic
27708008
EAF7_YEASTEAF7genetic
27708008
2A5D_YEASTRTS1genetic
27708008
BECN1_YEASTVPS30genetic
27708008
KAR3_YEASTKAR3genetic
27708008
ATG13_YEASTATG13genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PDR15_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-94, AND MASSSPECTROMETRY.

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