| UniProt ID | OST2_YEAST | |
|---|---|---|
| UniProt AC | P46964 | |
| Protein Name | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2 | |
| Gene Name | OST2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 130 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein. |
|
| Protein Description | Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.. | |
| Protein Sequence | MAKAPKANTPKVTSTSSAVLTDFQETFKTSKRAYFAQIEKYPKLKLIDTFCFFLVLLGVIQCTFIILIRDNFPFNAFLAGFIICVGQFVLLMSLRLQLCNSFPGISKNRAFAEFIVASLILHFVCLHFIN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | AKAPKANTPKVTSTS CCCCCCCCCCCCCCC | 29.37 | 24961812 | |
| 13 | Phosphorylation | KANTPKVTSTSSAVL CCCCCCCCCCCHHHH | 32.20 | 24961812 | |
| 14 | Phosphorylation | ANTPKVTSTSSAVLT CCCCCCCCCCHHHHH | 29.31 | 24961812 | |
| 15 | Phosphorylation | NTPKVTSTSSAVLTD CCCCCCCCCHHHHHH | 19.82 | 21440633 | |
| 21 | Phosphorylation | STSSAVLTDFQETFK CCCHHHHHHHHHHHH | 28.33 | 19779198 | |
| 28 | Acetylation | TDFQETFKTSKRAYF HHHHHHHHHCCHHHH | 60.35 | 24489116 | |
| 40 | Acetylation | AYFAQIEKYPKLKLI HHHHHHHHCCCCHHH | 69.36 | 22865919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of OST2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of OST2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of OST2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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