MRL1_YEAST - dbPTM
MRL1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MRL1_YEAST
UniProt AC Q06815
Protein Name Mannose 6-phosphate receptor-like protein 1
Gene Name MRL1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 381
Subcellular Localization Golgi apparatus, trans-Golgi network membrane
Single-pass type I membrane protein. Endosome membrane
Single-pass type I membrane protein.
Protein Description Sorting receptor involved in the transport of vacuolar enzymes from the Golgi complex to the vacuole. Involved in the delivery and maturation of PEP4 (vacuolar proteinase A) and PRB1 (vacuolar proteinase B)..
Protein Sequence MLKRSSLIYLSCVLIITIPILLHVYNGPGLSHEANEHRASHKQKRTLANPDKPKSENDEDLFCAVTNPVTGSYIDLSQLSSTPNKLREGQKQISGNNKHESSKTKWSVRGWGYDTNFTLGICSSPVGEAESQQLSNLTGAFYVDQLNENNLVSIGDFSTRPALVGGSTAKKLTLKYENGSMCPNGKDKKATLLNFVCDKEIQSKAQISYIGNLHNCSYFFEVRSIHACPTSNKKNEVNVLGIFIGIFAIFFLVEFAGRRWIYAKLNRHLKNDDELHDISPSLNEQPHWDLIEDGSRWSKFFNGIIKTTRRFTKSLMRSLVRGRNSRQGGIRLRSSPSASSSSLANREFFRDMEAQNEIIDSLDINSHTTESDHPTLADNSV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
77PhosphorylationTGSYIDLSQLSSTPN
CCCEECHHHCCCCCC		25.9028889911
116N-linked_GlycosylationRGWGYDTNFTLGICS
EECCCCCCEEEEEEC		25.63-
136N-linked_GlycosylationAESQQLSNLTGAFYV
HHHHHHHHCCCCEEE		50.65-
178N-linked_GlycosylationKLTLKYENGSMCPNG
CEEEEEECCCCCCCC		44.76-
215N-linked_GlycosylationSYIGNLHNCSYFFEV
EECCCCCCCEEEEEE		21.42-
279PhosphorylationDDELHDISPSLNEQP
CHHHHCCCCCCCCCC		17.9422369663
281PhosphorylationELHDISPSLNEQPHW
HHHCCCCCCCCCCCC		36.7222369663
299AcetylationEDGSRWSKFFNGIIK
CCCCHHHHHHHHHHH		47.1924489116
306AcetylationKFFNGIIKTTRRFTK
HHHHHHHHHHHHHHH		41.7624489116
314PhosphorylationTTRRFTKSLMRSLVR
HHHHHHHHHHHHHHC		25.0826447709
318PhosphorylationFTKSLMRSLVRGRNS
HHHHHHHHHHCCCCC		19.7627017623
325PhosphorylationSLVRGRNSRQGGIRL
HHHCCCCCCCCCEEE		25.3130377154
334PhosphorylationQGGIRLRSSPSASSS
CCCEEEECCCCCCCC		51.7122369663
335PhosphorylationGGIRLRSSPSASSSS
CCEEEECCCCCCCCH		19.2122369663
337PhosphorylationIRLRSSPSASSSSLA
EEEECCCCCCCCHHH		42.6122369663
339PhosphorylationLRSSPSASSSSLANR
EECCCCCCCCHHHCH		34.7822369663
340PhosphorylationRSSPSASSSSLANRE
ECCCCCCCCHHHCHH		24.5422369663
341PhosphorylationSSPSASSSSLANREF
CCCCCCCCHHHCHHH		27.2022369663
342PhosphorylationSPSASSSSLANREFF
CCCCCCCHHHCHHHH		33.1922369663
361PhosphorylationAQNEIIDSLDINSHT
HHHHHHHHCCCCCCC		19.9619779198
366PhosphorylationIDSLDINSHTTESDH
HHHCCCCCCCCCCCC		23.6519779198
368PhosphorylationSLDINSHTTESDHPT
HCCCCCCCCCCCCCC		31.8919779198
371PhosphorylationINSHTTESDHPTLAD
CCCCCCCCCCCCCCC		38.8428889911
375PhosphorylationTTESDHPTLADNSV-
CCCCCCCCCCCCCC-		31.0319779198
380PhosphorylationHPTLADNSV------
CCCCCCCCC------		29.7428889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MRL1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MRL1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MRL1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VPS10_YEASTPEP1genetic
11470415
BPH1_YEASTBPH1genetic
20093466
PAA1_YEASTPAA1genetic
20093466
MNN10_YEASTMNN10genetic
20093466
STP1_YEASTSTP1genetic
20093466
VPS60_YEASTVPS60genetic
20093466
VPS55_YEASTVPS55genetic
20093466
HOC1_YEASTHOC1genetic
20093466
MRT4_YEASTMRT4genetic
20093466
VPS51_YEASTVPS51genetic
20093466
DID2_YEASTDID2genetic
20093466
VPS13_YEASTVPS13genetic
20093466
RIC1_YEASTRIC1genetic
20093466
YPT6_YEASTYPT6genetic
20093466
MVP1_YEASTMVP1genetic
20093466
CIK1_YEASTCIK1genetic
20093466
VPS27_YEASTVPS27genetic
20093466
VPS68_YEASTVPS68genetic
20093466
VPS21_YEASTVPS21genetic
20093466
SCO1_YEASTSCO1physical
16093310
ADP1_YEASTADP1physical
16093310
DPP1_YEASTDPP1physical
16093310
PMP2_YEASTPMP2physical
16093310
TVP38_YEASTTVP38physical
16093310
PTR2_YEASTPTR2physical
16093310
YNT4_YEASTYNL194Cphysical
16093310
YP162_YEASTYPL162Cphysical
16093310
MRL1_YEASTMRL1physical
16093310
AVT5_YEASTAVT5genetic
27708008
BPH1_YEASTBPH1genetic
27708008
MNN10_YEASTMNN10genetic
27708008
STP1_YEASTSTP1genetic
27708008
VPS60_YEASTVPS60genetic
27708008
GET2_YEASTGET2genetic
27708008
RTF1_YEASTRTF1genetic
27708008
DAL81_YEASTDAL81genetic
27708008
VPS55_YEASTVPS55genetic
27708008
HOC1_YEASTHOC1genetic
27708008
MRT4_YEASTMRT4genetic
27708008
VPS24_YEASTVPS24genetic
27708008
DID2_YEASTDID2genetic
27708008
RIC1_YEASTRIC1genetic
27708008
YPT6_YEASTYPT6genetic
27708008
MVP1_YEASTMVP1genetic
27708008
VPS27_YEASTVPS27genetic
27708008
VPS68_YEASTVPS68genetic
27708008
RRP6_YEASTRRP6genetic
27708008
VPS21_YEASTVPS21genetic
27708008
WDR59_YEASTMTC5genetic
29674565
SUM1_YEASTSUM1genetic
29674565
ATC7_YEASTNEO1genetic
29674565
SYS1_YEASTSYS1genetic
29674565
CBF1_YEASTCBF1genetic
29674565
HOC1_YEASTHOC1genetic
29674565
BCK1_YEASTBCK1genetic
29674565
CND2_YEASTBRN1genetic
29674565
ALG14_YEASTALG14genetic
29674565
TRS20_YEASTTRS20genetic
29674565
PDC2_YEASTPDC2genetic
29674565
UBC13_YEASTUBC13genetic
29674565
TRS23_YEASTTRS23genetic
29674565
VPS60_YEASTVPS60genetic
29674565
MON1_YEASTMON1genetic
29674565
VPS24_YEASTVPS24genetic
29674565
VPS51_YEASTVPS51genetic
29674565
VPS13_YEASTVPS13genetic
29674565
RIC1_YEASTRIC1genetic
29674565
VTA1_YEASTVTA1genetic
29674565
YPT6_YEASTYPT6genetic
29674565
POB3_YEASTPOB3genetic
29674565
PKR1_YEASTPKR1genetic
29674565
CKS1_YEASTCKS1genetic
29674565
MCM7_YEASTMCM7genetic
29674565
NSE4_YEASTNSE4genetic
29674565
MSN5_YEASTMSN5genetic
29674565
SAC7_YEASTSAC7genetic
29674565
GPI19_YEASTGPI19genetic
29674565
SWI4_YEASTSWI4genetic
29674565
BEM2_YEASTBEM2genetic
29674565
IRE1_YEASTIRE1genetic
29674565
CTF8_YEASTCTF8genetic
29674565
OST1_YEASTOST1genetic
29674565
RL14A_YEASTRPL14Agenetic
29674565
ELM1_YEASTELM1genetic
29674565
ZRT3_YEASTZRT3genetic
29674565
LST4_YEASTLST4genetic
29674565
IMB1_YEASTKAP95genetic
29674565
SC61A_YEASTSEC61genetic
29674565
ERG2_YEASTERG2genetic
29674565
GRPE_YEASTMGE1genetic
29674565
NAB3_YEASTNAB3genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MRL1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334; SER-335; SER-337;SER-339; SER-340; SER-371 AND SER-380, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-337, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335; SER-339 ANDSER-342, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-339, ANDMASS SPECTROMETRY.

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