ADP1_YEAST - dbPTM
ADP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADP1_YEAST
UniProt AC P25371
Protein Name Probable ATP-dependent permease
Gene Name ADP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1049
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description
Protein Sequence MGSHRRYLYYSILSFLLLSCSVVLAKQDKTPFFEGTSSKNSRLTAQDKGNDTCPPCFNCMLPIFECKQFSECNSYTGRCECIEGFAGDDCSLPLCGGLSPDESGNKDRPIRAQNDTCHCDNGWGGINCDVCQEDFVCDAFMPDPSIKGTCYKNGMIVDKVFSGCNVTNEKILQILNGKIPQITFACDKPNQECNFQFWIDQLESFYCGLSDCAFEYDLEQNTSHYKCNDVQCKCVPDTVLCGAKGSIDISDFLTETIKGPGDFSCDLETRQCKFSEPSMNDLILTVFGDPYITLKCESGECVHYSEIPGYKSPSKDPTVSWQGKLVLALTAVMVLALFTFATFYISKSPLFRNGLGSSKSPIRLPDEDAVNNFLQNEDDTLATLSFENITYSVPSINSDGVEETVLNEISGIVKPGQILAIMGGSGAGKTTLLDILAMKRKTGHVSGSIKVNGISMDRKSFSKIIGFVDQDDFLLPTLTVFETVLNSALLRLPKALSFEAKKARVYKVLEELRIIDIKDRIIGNEFDRGISGGEKRRVSIACELVTSPLVLFLDEPTSGLDASNANNVIECLVRLSSDYNRTLVLSIHQPRSNIFYLFDKLVLLSKGEMVYSGNAKKVSEFLRNEGYICPDNYNIADYLIDITFEAGPQGKRRRIRNISDLEAGTDTNDIDNTIHQTTFTSSDGTTQREWAHLAAHRDEIRSLLRDEEDVEGTDGRRGATEIDLNTKLLHDKYKDSVYYAELSQEIEEVLSEGDEESNVLNGDLPTGQQSAGFLQQLSILNSRSFKNMYRNPKLLLGNYLLTILLSLFLGTLYYNVSNDISGFQNRMGLFFFILTYFGFVTFTGLSSFALERIIFIKERSNNYYSPLAYYISKIMSEVVPLRVVPPILLSLIVYPMTGLNMKDNAFFKCIGILILFNLGISLEILTIGIIFEDLNNSIILSVLVLLGSLLFSGLFINTKNITNVAFKYLKNFSVFYYAYESLLINEVKTLMLKERKYGLNIEVPGATILSTFGFVVQNLVFDIKILALFNVVFLIMGYLALKWIVVEQK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
50N-linked_GlycosylationLTAQDKGNDTCPPCF
CCCHHCCCCCCCCCC		47.35-
114N-linked_GlycosylationDRPIRAQNDTCHCDN
CCCCCCCCCCCCCCC		45.64-
165N-linked_GlycosylationDKVFSGCNVTNEKIL
EEECCCCCCCCHHHH		47.36-
221N-linked_GlycosylationFEYDLEQNTSHYKCN
EEEECCCCCCCCCCC		33.89-
359UbiquitinationRNGLGSSKSPIRLPD
CCCCCCCCCCCCCCC		63.0523749301
431PhosphorylationGSGAGKTTLLDILAM
CCCCCHHHHHHHHHH		28.8928889911
659PhosphorylationRRRIRNISDLEAGTD
CEECCCHHHCCCCCC		39.4322369663
667PhosphorylationDLEAGTDTNDIDNTI
HCCCCCCCCCCCCEE		34.3327017623
673PhosphorylationDTNDIDNTIHQTTFT
CCCCCCCEEEEEEEE		18.9819779198
677PhosphorylationIDNTIHQTTFTSSDG
CCCEEEEEEEECCCC		15.0917563356
678PhosphorylationDNTIHQTTFTSSDGT
CCEEEEEEEECCCCC		20.5328889911
680PhosphorylationTIHQTTFTSSDGTTQ
EEEEEEEECCCCCCH		25.8119779198
681PhosphorylationIHQTTFTSSDGTTQR
EEEEEEECCCCCCHH		23.4219779198
682PhosphorylationHQTTFTSSDGTTQRE
EEEEEECCCCCCHHH		36.6819779198
685PhosphorylationTFTSSDGTTQREWAH
EEECCCCCCHHHHHH		25.4219779198
686PhosphorylationFTSSDGTTQREWAHL
EECCCCCCHHHHHHH		31.0319779198
702PhosphorylationAHRDEIRSLLRDEED
HCHHHHHHHHCCHHH		37.1022369663
713PhosphorylationDEEDVEGTDGRRGAT
CHHHCCCCCCCCCCE		23.0623607784
860PhosphorylationIIFIKERSNNYYSPL
EEEEECCCCCCCCHH		30.4428889911
863PhosphorylationIKERSNNYYSPLAYY
EECCCCCCCCHHHHH		15.0128889911
864PhosphorylationKERSNNYYSPLAYYI
ECCCCCCCCHHHHHH		13.1128889911
865PhosphorylationERSNNYYSPLAYYIS
CCCCCCCCHHHHHHH		11.7728889911
869PhosphorylationNYYSPLAYYISKIMS
CCCCHHHHHHHHHHH		14.7128889911
870PhosphorylationYYSPLAYYISKIMSE
CCCHHHHHHHHHHHC		7.9728889911
935N-linked_GlycosylationGIIFEDLNNSIILSV
HHHHHCCCCHHHHHH		53.15-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ADP1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADP1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AGP1_YEASTAGP1genetic
16269340
HAC1_YEASTHAC1genetic
16269340
SEC66_YEASTSEC66genetic
16269340
RIC1_YEASTRIC1genetic
16269340
PLMT_YEASTOPI3genetic
16269340
RGP1_YEASTRGP1genetic
16269340
GAS1_YEASTGAS1genetic
16269340
MKAR_YEASTIFA38physical
16093310
GSH1_YEASTGSH1genetic
22526809
GSHB_YEASTGSH2genetic
22526809
HSP72_YEASTSSA2physical
22940862
HSP71_YEASTSSA1physical
22940862
ERG27_YEASTERG27physical
23831759
DPM1_YEASTDPM1physical
23831759
OST2_YEASTOST2physical
23831759
ORM2_YEASTORM2physical
23831759
SOP4_YEASTSOP4physical
23831759
SMF2_YEASTSMF2physical
23831759
VATO_YEASTVMA16physical
23831759
VATL1_YEASTVMA3physical
23831759
YD24B_YEASTYDR524C-Bphysical
23831759
AP1_YEASTYAP1genetic
25600293
ATR1_YEASTATR1genetic
25600293
CND2_YEASTBRN1genetic
27708008
RPN5_YEASTRPN5genetic
27708008
RPB7_YEASTRPB7genetic
27708008
MCM1_YEASTMCM1genetic
27708008
MED7_YEASTMED7genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADP1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-659; THR-678 ANDSER-702, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-677, AND MASSSPECTROMETRY.

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