| UniProt ID | SMF2_YEAST | |
|---|---|---|
| UniProt AC | P38778 | |
| Protein Name | Manganese transporter SMF2 | |
| Gene Name | SMF2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 549 | |
| Subcellular Localization |
Vacuole membrane Multi-pass membrane protein . Targeted to the vacuolar lumen in presence of excess manganese, where it is degraded. |
|
| Protein Description | High-affinity manganese transporter involved in mobilizing manganese from vesicular stores iin conditions of low manganese ion concentrations.. | |
| Protein Sequence | MTSQEYEPIQWSDESQTNNDSVNDAYADVNTTHESRRRTTLQPNSTSQSMIGTLRKYARFIGPGLMVSVSYMDPGNYSTAVAAGSAHRYKLLFSVLVSNFMAAFWQYLCARLGAVTGLDLAQNCKKHLPFGLNITLYILAEMAIIATDLAEVVGTAISLNILFHIPLALGVILTVVDVLIVLLAYKPNGSMKGIRIFEAFVSLLVVLTVVCFTVELFYAKLGPAKEIFSGFLPSKAVFEGDGLYLSLAILGATVMPHSLYLGSGVVQPRLREYDIKNGHYLPDANDMDNNHDNYRPSYEAISETLHFTITELLISLFTVALFVNCAILIVSGATLYGSTQNAEEADLFSIYNLLCSTLSKGAGTVFVLALLFSGQSAGIVCTLSGQMVSEGFLNWTVSPALRRSATRAVAITPCLILVLVAGRSGLSGALNASQVVLSLLLPFVSAPLLYFTSSKKIMRVQLNRTKELSRTTDKKPVADRTEDDETIELEEMGIGSSSQERSLVSPAPEYKDMSNGMIVTVLAIIVWLIISGLNFYMLLGFTTGKEVHL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MTSQEYEPI ------CCCCCCCCC | 38.83 | 22369663 | |
| 3 | Phosphorylation | -----MTSQEYEPIQ -----CCCCCCCCCC | 21.51 | 22369663 | |
| 6 | Phosphorylation | --MTSQEYEPIQWSD --CCCCCCCCCCCCC | 21.26 | 22369663 | |
| 12 | Phosphorylation | EYEPIQWSDESQTNN CCCCCCCCCCCCCCC | 18.35 | 22369663 | |
| 15 | Phosphorylation | PIQWSDESQTNNDSV CCCCCCCCCCCCCCC | 47.50 | 22369663 | |
| 17 | Phosphorylation | QWSDESQTNNDSVND CCCCCCCCCCCCCCH | 45.31 | 22369663 | |
| 21 | Phosphorylation | ESQTNNDSVNDAYAD CCCCCCCCCCHHHHH | 25.58 | 23749301 | |
| 39 | Phosphorylation | THESRRRTTLQPNST CCHHHCCCCCCCCCC | 30.01 | 28889911 | |
| 40 | Phosphorylation | HESRRRTTLQPNSTS CHHHCCCCCCCCCCC | 22.91 | 28889911 | |
| 46 | Phosphorylation | TTLQPNSTSQSMIGT CCCCCCCCCHHHHHH | 37.11 | 27017623 | |
| 53 | Phosphorylation | TSQSMIGTLRKYARF CCHHHHHHHHHHHHH | 16.68 | 28889911 | |
| 481 | Phosphorylation | KKPVADRTEDDETIE CCCCCCCCCCCCCEE | 44.29 | 24961812 | |
| 486 | Phosphorylation | DRTEDDETIELEEMG CCCCCCCCEEHHHCC | 27.09 | 24961812 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SMF2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SMF2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SMF2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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