NOP14_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOP14_YEAST
• UniProt AC: Q99207
• Protein Name: Nucleolar complex protein 14
• Gene Name: NOP14
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 810
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm..
• Protein Sequence: MAGSQLKNLKAALKARGLTGQTNVKSKNKKNSKRQAKEYDREEKKKAIAEIREEFNPFEIKAARNKRRDGLPSKTADRIAVGKPGISKQIGEEQRKRAFEARKMMKNKRGGVIDKRFGERDKLLTEEEKMLERFTRERQSQSKRNANLFNLEDDEDDGDMFGDGLTHLGQSLSLEDELANDEEDFLASKRFNEDDAELQQPQRKKTKAEVMKEVIAKSKFYKQERQKAQGIMEDQIDNLDDNFEDVMSELMMTQPKKNPMEPKTDLDKEYDIKVKELQLDKRAAPSDRTKTEEEKNAEAEEKKRELEQQRLDRMNGMIELEEGEERGVEDLDDGFWENEEDYEDDNDGIADSDDDIKFEDQGRDEGFSQILKKKNISISCPRTHDALLDQVKKLDLDDHPKIVKNIIKAYQPKLAEGNKEKLGKFTAVLLRHIIFLSNQNYLKNVQSFKRTQNALISILKSLSEKYNRELSEECRDYINEMQARYKKNHFDALSNGDLVFFSIIGILFSTSDQYHLVITPALILMSQFLEQIKFNSLKRIAFGAVLVRIVSQYQRISKRYIPEVVYFFQKILLTFIVEKENQEKPLDFENIRLDSYELGLPLDVDFTKKRSTIIPLHTLSTMDTEAHPVDQCVSVLLNVMESLDATISTVWKSLPAFNEIILPIQQLLSAYTSKYSDFEKPRNILNKVEKLTKFTEHIPLALQNHKPVSIPTHAPKYEENFNPDKKSYDPDRTRSEINKMKAQLKKERKFTMKEIRKDAKFEARQRIEEKNKESSDYHAKMAHIVNTINTEEGAEKNKYERERKLRGGKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Acetylation	GSQLKNLKAALKARG CHHHHHHHHHHHHCC	40.79	25381059
37	Acetylation	KNSKRQAKEYDREEK HCHHHHHHHHCHHHH	48.76	25381059
88	Acetylation	VGKPGISKQIGEEQR CCCCCHHHHHCHHHH	43.97	24489116
212	Acetylation	KTKAEVMKEVIAKSK HHHHHHHHHHHHHCH	54.74	25381059
273	Acetylation	LDKEYDIKVKELQLD CCHHHCEEEEEHHHC	44.34	24489116
281	Acetylation	VKELQLDKRAAPSDR EEEHHHCCCCCCCCC	53.15	25381059
291	Phosphorylation	APSDRTKTEEEKNAE CCCCCCCCHHHHHHH	48.27	27214570
352	Phosphorylation	DNDGIADSDDDIKFE CCCCCCCCCCCCCCC	33.64	25704821
368	Phosphorylation	QGRDEGFSQILKKKN CCCCCCHHHHHHHCC	27.45	28132839
377	Phosphorylation	ILKKKNISISCPRTH HHHHCCCEEECCCHH	20.17	27017623
379	Phosphorylation	KKKNISISCPRTHDA HHCCCEEECCCHHHH	15.98	27017623
424	Acetylation	GNKEKLGKFTAVLLR CCHHHHHHHHHHHHH	50.40	24489116
551	Phosphorylation	AVLVRIVSQYQRISK HHHHHHHHHHHHHHH	22.31	27017623
680	Ubiquitination	SKYSDFEKPRNILNK HCCCCCCCHHHHHHH	49.63	23749301
687	Acetylation	KPRNILNKVEKLTKF CHHHHHHHHHHHHHH	48.61	25381059
690	Acetylation	NILNKVEKLTKFTEH HHHHHHHHHHHHHCC	65.53	24489116
693	Acetylation	NKVEKLTKFTEHIPL HHHHHHHHHHCCCCH	61.80	22865919
716	Acetylation	SIPTHAPKYEENFNP CCCCCCCCCHHHCCC	67.11	22865919
726	Acetylation	ENFNPDKKSYDPDRT HHCCCCCCCCCCCCC	62.72	24489116
735	Phosphorylation	YDPDRTRSEINKMKA CCCCCCHHHHHHHHH	42.06	30377154
739	Acetylation	RTRSEINKMKAQLKK CCHHHHHHHHHHHHH	47.65	25381059
753	Acetylation	KERKFTMKEIRKDAK HHHCCCHHHHHHHHH	47.10	25381059
774	Phosphorylation	IEEKNKESSDYHAKM HHHHHHHCCHHHHHH	30.07	28889911
775	Phosphorylation	EEKNKESSDYHAKMA HHHHHHCCHHHHHHH	43.19	28889911
796	Acetylation	NTEEGAEKNKYERER CCCCHHHHCHHHHHH	59.20	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NOP14_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOP14_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOP14_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ENP1_YEAST	ENP1	physical	12150911
KRR1_YEAST	KRR1	physical	12150911
NOC4_YEAST	NOC4	physical	12150911
BFR2_YEAST	BFR2	physical	12150911
BMS1_YEAST	BMS1	physical	12150911
DHR1_YEAST	ECM16	physical	12150911
NEP1_YEAST	EMG1	physical	12150911
HAS1_YEAST	HAS1	physical	12150911
NAT10_YEAST	KRE33	physical	12150911
GYP2_YEAST	MDR1	physical	12150911
MPP10_YEAST	MPP10	physical	12150911
UTP17_YEAST	NAN1	physical	12150911
FBRL_YEAST	NOP1	physical	12150911
NOP14_YEAST	NOP14	physical	12150911
RL4A_YEAST	RPL4A	physical	12150911
RS17A_YEAST	RPS17A	physical	12150911
RS17B_YEAST	RPS17B	physical	12150911
RS3A1_YEAST	RPS1A	physical	12150911
RS24A_YEAST	RPS24B	physical	12150911
RS24B_YEAST	RPS24B	physical	12150911
RS4A_YEAST	RPS4A	physical	12150911
RS4B_YEAST	RPS4A	physical	12150911
RS7A_YEAST	RPS7A	physical	12150911
RRP12_YEAST	RRP12	physical	12150911
RRP5_YEAST	RRP5	physical	12150911
UTP20_YEAST	UTP20	physical	12150911
UTP22_YEAST	UTP22	physical	12150911
UTP8_YEAST	UTP8	physical	12150911
UTP13_YEAST	UTP13	physical	12150911
MPP10_YEAST	MPP10	physical	12068309
NOC4_YEAST	NOC4	physical	12446671
NEP1_YEAST	EMG1	physical	11694595
BFR2_YEAST	BFR2	physical	16429126
BMS1_YEAST	BMS1	physical	16429126
DHR1_YEAST	ECM16	physical	16429126
NEP1_YEAST	EMG1	physical	16429126
MPP10_YEAST	MPP10	physical	16429126
NOC4_YEAST	NOC4	physical	16429126
FBRL_YEAST	NOP1	physical	16429126
RS11A_YEAST	RPS11A	physical	16429126
RS11B_YEAST	RPS11A	physical	16429126
RS17A_YEAST	RPS17A	physical	16429126
RS24A_YEAST	RPS24B	physical	16429126
RS24B_YEAST	RPS24B	physical	16429126
RS4A_YEAST	RPS4A	physical	16429126
RS4B_YEAST	RPS4A	physical	16429126
UTP13_YEAST	UTP13	physical	16429126
UTP22_YEAST	UTP22	physical	16429126
ENP1_YEAST	ENP1	physical	16429126
NAT10_YEAST	KRE33	physical	16429126
KRI1_YEAST	KRI1	physical	16429126
RS8A_YEAST	RPS8A	physical	16429126
RS8B_YEAST	RPS8A	physical	16429126
RRP12_YEAST	RRP12	physical	16429126
UTP20_YEAST	UTP20	physical	16429126
RS3A1_YEAST	RPS1A	physical	16429126
RRP5_YEAST	RRP5	physical	16429126
RS7A_YEAST	RPS7A	physical	16429126
TSR1_YEAST	TSR1	physical	16429126
UTP17_YEAST	NAN1	physical	16429126
UTP8_YEAST	UTP8	physical	16429126
BUD23_YEAST	BUD23	physical	23604635

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.