| UniProt ID | NOC4_YEAST | |
|---|---|---|
| UniProt AC | Q06512 | |
| Protein Name | Nucleolar complex protein 4 | |
| Gene Name | NOC4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 552 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm. Its subcellular location and association with pre-40S subunit are unaffected by RPS19 disruptions, suggesting it acts before the ribosomal protein.. | |
| Protein Sequence | MVLLISEIKDIAKRLTAAGDRKQYNSIIKLINELVIPENVTQLEEDETEKNLRFLVMSLFQIFRKLFSRGDLTLPSSKKSTLEKEQFVNWCRKVYEAFKTKLLAIISDIPFETSLGLDSLDVYLQLAELESTHFASEKGAPFFPNKTFRKLIIALWSSNMGEIEDVKSSGASENLIIVEFTEKYYTKFADIQYYFQSEFNQLLEDPAYQDLLLKNVGKWLALVNHDKHCSSVDADLEIFVPNPPQAIENESKFKSNFEKNWLSLLNGQLSLQQYKSILLILHKRIIPHFHTPTKLMDFLTDSYNLQSSNKNAGVVPILALNGLFELMKRFNLEYPNFYMKLYQIINPDLMHVKYRARFFRLMDVFLSSTHLSAHLVASFIKKLARLTLESPPSAIVTVIPFIYNLIRKHPNCMIMLHNPAFISNPFQTPDQVANLKTLKENYVDPFDVHESDPELTHALDSSLWELASLMEHYHPNVATLAKIFAQPFKKLSYNMEDFLDWNYDSLLNAESSRKLKTLPTLEFEAFTNVFDNEDGDSEASSQGNVYLPGVAW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 68 | Phosphorylation | QIFRKLFSRGDLTLP HHHHHHHHCCCCCCC | 45.87 | 19823750 | |
| 73 | Phosphorylation | LFSRGDLTLPSSKKS HHHCCCCCCCCCCCC | 41.17 | 19823750 | |
| 76 | Phosphorylation | RGDLTLPSSKKSTLE CCCCCCCCCCCCHHC | 58.88 | 19823750 | |
| 77 | Phosphorylation | GDLTLPSSKKSTLEK CCCCCCCCCCCHHCH | 42.01 | 19823750 | |
| 146 | Acetylation | GAPFFPNKTFRKLII CCCCCCCHHHHHHHH | 49.64 | 24489116 | |
| 168 | Phosphorylation | GEIEDVKSSGASENL CCHHHHHHCCCCCCE | 33.58 | 27017623 | |
| 169 | Phosphorylation | EIEDVKSSGASENLI CHHHHHHCCCCCCEE | 32.43 | 27017623 | |
| 353 | Acetylation | NPDLMHVKYRARFFR CCCCCCHHHHHHHHH | 17.84 | 24489116 | |
| 503 | Phosphorylation | EDFLDWNYDSLLNAE HHHHCCCHHHHCCHH | 11.58 | 27017623 | |
| 505 | Phosphorylation | FLDWNYDSLLNAESS HHCCCHHHHCCHHHH | 25.13 | 27017623 | |
| 512 | Phosphorylation | SLLNAESSRKLKTLP HHCCHHHHHCCCCCC | 25.58 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NOC4_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NOC4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NOC4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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