RS11B_YEAST - dbPTM
RS11B_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RS11B_YEAST
UniProt AC P0CX48
Protein Name 40S ribosomal protein S11-B {ECO:0000303|PubMed:9559554}
Gene Name RPS11B {ECO:0000303|PubMed:9559554}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 156
Subcellular Localization Cytoplasm .
Protein Description Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel..
Protein Sequence MSTELTVQSERAFQKQPHIFNNPKVKTSKRTKRWYKNAGLGFKTPKTAIEGSYIDKKCPFTGLVSIRGKILTGTVVSTKMHRTIVIRRAYLHYIPKYNRYEKRHKNVPVHVSPAFRVQVGDIVTVGQCRPISKTVRFNVVKVSAAAGKANKQFAKF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSTELTVQS
------CCCEEEHHC		30.5022814378
2Phosphorylation------MSTELTVQS
------CCCEEEHHC		30.5022369663
3Phosphorylation-----MSTELTVQSE
-----CCCEEEHHCH		33.4422369663
6Phosphorylation--MSTELTVQSERAF
--CCCEEEHHCHHHH		15.4022369663
9PhosphorylationSTELTVQSERAFQKQ
CCEEEHHCHHHHHHC		25.3924909858
15UbiquitinationQSERAFQKQPHIFNN
HCHHHHHHCCCCCCC		60.3823749301
24UbiquitinationPHIFNNPKVKTSKRT
CCCCCCCCCCCCHHC		59.4923749301
26UbiquitinationIFNNPKVKTSKRTKR
CCCCCCCCCCHHCHH		53.8922817900
29UbiquitinationNPKVKTSKRTKRWYK
CCCCCCCHHCHHHHH		70.1322817900
32UbiquitinationVKTSKRTKRWYKNAG
CCCCHHCHHHHHHCC		44.9922817900
36UbiquitinationKRTKRWYKNAGLGFK
HHCHHHHHHCCCCCC		33.1023749301
43UbiquitinationKNAGLGFKTPKTAIE
HHCCCCCCCCCCCEE		63.2223749301
44PhosphorylationNAGLGFKTPKTAIEG
HCCCCCCCCCCCEEC		27.9622369663
46UbiquitinationGLGFKTPKTAIEGSY
CCCCCCCCCCEECCC		56.6823749301
47PhosphorylationLGFKTPKTAIEGSYI
CCCCCCCCCEECCCC		33.7928889911
52PhosphorylationPKTAIEGSYIDKKCP
CCCCEECCCCCCCCC		13.2120377248
53PhosphorylationKTAIEGSYIDKKCPF
CCCEECCCCCCCCCC		24.8121440633
56UbiquitinationIEGSYIDKKCPFTGL
EECCCCCCCCCCCEE		46.8723749301
57UbiquitinationEGSYIDKKCPFTGLV
ECCCCCCCCCCCEEE		43.3123749301
61PhosphorylationIDKKCPFTGLVSIRG
CCCCCCCCEEEEECC		18.1022369663
65PhosphorylationCPFTGLVSIRGKILT
CCCCEEEEECCEEEC		16.1722369663
69UbiquitinationGLVSIRGKILTGTVV
EEEEECCEEECCEEE		25.3723749301
72PhosphorylationSIRGKILTGTVVSTK
EECCEEECCEEEECC		33.9922369663
74PhosphorylationRGKILTGTVVSTKMH
CCEEECCEEEECCCC		16.7022369663
77PhosphorylationILTGTVVSTKMHRTI
EECCEEEECCCCEEE		20.2720377248
78PhosphorylationLTGTVVSTKMHRTIV
ECCEEEECCCCEEEE		22.3021440633
79UbiquitinationTGTVVSTKMHRTIVI
CCEEEECCCCEEEEE		25.7923749301
90PhosphorylationTIVIRRAYLHYIPKY
EEEEEHHHHHHHHCC		7.6928889911
96UbiquitinationAYLHYIPKYNRYEKR
HHHHHHHCCCCCHHH		45.6723749301
102UbiquitinationPKYNRYEKRHKNVPV
HCCCCCHHHHCCCCE		51.3622817900
105UbiquitinationNRYEKRHKNVPVHVS
CCCHHHHCCCCEEEC		64.7723749301
112PhosphorylationKNVPVHVSPAFRVQV
CCCCEEECCCEEEEC		8.8128889911
132PhosphorylationVGQCRPISKTVRFNV
EEECEECCCEEEEEE		25.5924909858
133UbiquitinationGQCRPISKTVRFNVV
EECEECCCEEEEEEE		52.3223749301
141UbiquitinationTVRFNVVKVSAAAGK
EEEEEEEEEEECCHH		26.6223749301
143PhosphorylationRFNVVKVSAAAGKAN
EEEEEEEEECCHHHH		13.3821440633
148UbiquitinationKVSAAAGKANKQFAK
EEEECCHHHHHHHCC		44.0223749301
151UbiquitinationAAAGKANKQFAKF--
ECCHHHHHHHCCC--		52.2123749301
155UbiquitinationKANKQFAKF------
HHHHHHCCC------		53.5523749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RS11B_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RS11B_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RS11B_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NMD5_YEASTNMD5genetic
19061648
MAK5_YEASTMAK5genetic
27708008
MED8_YEASTMED8genetic
27708008
TRS20_YEASTTRS20genetic
27708008
CAF4_YEASTCAF4genetic
27708008
ENV10_YEASTENV10genetic
27708008
ACE2_YEASTACE2genetic
27708008
STE23_YEASTSTE23genetic
27708008
LEO1_YEASTLEO1genetic
27708008
RL21B_YEASTRPL21Bgenetic
27708008
NIP80_YEASTNIP100genetic
27708008
RPN6_YEASTRPN6genetic
27708008
CDC4_YEASTCDC4genetic
27708008
SWC4_YEASTSWC4genetic
27708008
GPI16_YEASTGPI16genetic
27708008
BBP_YEASTMSL5genetic
27708008
SEC22_YEASTSEC22genetic
27708008
CDC91_YEASTGAB1genetic
27708008
PRP2_YEASTPRP2genetic
27708008
SMP3_YEASTSMP3genetic
27708008
GPI2_YEASTGPI2genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
AIR2_YEASTAIR2genetic
27708008
CAJ1_YEASTCAJ1genetic
27708008
IST3_YEASTIST3genetic
27708008
DAL81_YEASTDAL81genetic
27708008
VPS53_YEASTVPS53genetic
27708008
MUD2_YEASTMUD2genetic
27708008
SIC1_YEASTSIC1genetic
27708008
SEI1_YEASTFLD1genetic
27708008
YM96_YEASTYMR317Wgenetic
27708008
DOM34_YEASTDOM34genetic
27708008
PDAT_YEASTLRO1genetic
27708008
IES4_YEASTIES4genetic
27708008
VPH1_YEASTVPH1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
POC4_YEASTPOC4genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
PPME1_YEASTPPE1genetic
27453043
RL11B_YEASTRPL11Bgenetic
27453043
CYPC_YEASTCPR3genetic
27453043
MUP3_YEASTMUP3genetic
27453043
CTK2_YEASTCTK2genetic
27453043
INO2_YEASTINO2genetic
27453043
RPB3_YEASTRPB3genetic
27453043
BAS1_YEASTBAS1genetic
27453043
YJ66_YEASTYJR096Wgenetic
27453043
NHX1_YEASTNHX1genetic
27453043
BXI1_YEASTBXI1genetic
27453043
ERG26_YEASTERG26genetic
27453043
GAL4_YEASTGAL4genetic
27453043
KC12_YEASTYCK2genetic
27453043
AAKG_YEASTSNF4genetic
27453043
TPM1_YEASTTPM1genetic
27453043
UBA4_YEASTUBA4genetic
27453043
TAP42_YEASTTAP42genetic
27453043
KMO_YEASTBNA4genetic
27453043
ADE_YEASTAAH1genetic
27453043
QCR2_YEASTQCR2genetic
27453043
ATC2_YEASTPMC1genetic
27453043
LSM1_YEASTLSM1genetic
27453043
PNPH_YEASTPNP1genetic
27453043
MET32_YEASTMET32genetic
27453043
EAR1_YEASTEAR1genetic
27453043
AZF1_YEASTAZF1genetic
27453043
KAPA_YEASTTPK1genetic
27453043
PTR2_YEASTPTR2genetic
27453043
INO4_YEASTINO4genetic
27453043
SSN3_YEASTSSN3genetic
27453043
DOM34_YEASTDOM34genetic
27453043
HSC82_YEASTHSC82genetic
27453043
DCAM_YEASTSPE2genetic
27453043
AIM33_YEASTAIM33genetic
27453043
PUT2_YEASTPUT2genetic
27453043
ARP8_YEASTARP8genetic
27453043
SCH9_YEASTSCH9genetic
27453043
YIA6_YEASTYIA6genetic
27453043
YPT32_YEASTYPT32genetic
27453043
FLX1_YEASTFLX1genetic
27453043
CYPB_YEASTCPR2genetic
27453043
RS10A_YEASTRPS10Agenetic
27453043
FKBP_YEASTFPR1genetic
27453043
FAR10_YEASTFAR10genetic
27453043
RAS2_YEASTRAS2genetic
27453043
DCOR_YEASTSPE1genetic
27453043
NUC1_YEASTNUC1genetic
27453043
SHU1_YEASTSHU1genetic
27453043
TOR1_YEASTTOR1genetic
27453043
SIP2_YEASTSIP2genetic
27453043
GABAT_YEASTUGA1genetic
27453043
SNF1_YEASTSNF1genetic
27453043
SKY1_YEASTSKY1genetic
27453043
PGA3_YEASTPGA3genetic
27453043
CLA4_YEASTCLA4genetic
27453043
PDK1_YEASTPKP1genetic
27453043
PYRD_YEASTURA1genetic
27453043
RS19B_YEASTRPS19Bgenetic
27453043
F16P_YEASTFBP1genetic
27453043
REV1_YEASTREV1genetic
27453043
RS10B_YEASTRPS10Bgenetic
27453043
RPAC1_YEASTRPC40genetic
27453043
CYPD_YEASTCPR5genetic
27453043
NM111_YEASTNMA111genetic
27453043
LYP1_YEASTLYP1genetic
27453043
SLX8_YEASTSLX8genetic
27453043
MAP1_YEASTMAP1genetic
27453043
CTK3_YEASTCTK3genetic
27453043
HMDH1_YEASTHMG1genetic
27453043
DNM1_YEASTDNM1genetic
27453043
PMIP_YEASTOCT1genetic
27453043
HAL4_YEASTSAT4genetic
27453043
YND1_YEASTYND1genetic
27453043
PVH1_YEASTYVH1genetic
27453043
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RS11B_YEAST

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"NH2-terminal acetylation of ribosomal proteins of Saccharomycescerevisiae.";
Takakura H., Tsunasawa S., Miyagi M., Warner J.R.;
J. Biol. Chem. 267:5442-5445(1992).
Cited for: PROTEIN SEQUENCE OF 2-21, AND ACETYLATION AT SER-2 BY NATA.
Phosphorylation
ReferencePubMed
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-74, AND MASSSPECTROMETRY.

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