STE23_YEAST - dbPTM
STE23_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STE23_YEAST
UniProt AC Q06010
Protein Name A-factor-processing enzyme
Gene Name STE23
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1027
Subcellular Localization Membrane
Peripheral membrane protein .
Protein Description Involved in the N-terminal endoproteolytic cleavage of the P2 precursor of the a-factor mating pheromone. Capable of proteolysing the established mammalian insulin-degrading enzymes (IDEs) substrates amyloid-beta peptide and insulin B-chain..
Protein Sequence MGVSLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASKLILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPKLNNSSESE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
82AcetylationRFIELPNKLKALLIQ
CEEECCHHHHHHHHC		49.8024489116
92AcetylationALLIQDPKADKAAAS
HHHHCCCCCCHHHHH		76.9924489116
92SuccinylationALLIQDPKADKAAAS
HHHHCCCCCCHHHHH		76.9923954790
229PhosphorylationKHPYHKFSTGNIETL
CCCCCCCCCCCCCCC		39.9619823750
230PhosphorylationHPYHKFSTGNIETLG
CCCCCCCCCCCCCCC		37.0619823750
235PhosphorylationFSTGNIETLGTLPKE
CCCCCCCCCCCCCCC		27.0419823750
238PhosphorylationGNIETLGTLPKENGL
CCCCCCCCCCCCCCC		42.8919823750
318AcetylationIIQVRPVKDLKKLEI
HHEEEECCCCCCEEE		61.0924489116
439PhosphorylationFKFKQAGSPSSTVSS
EEEECCCCCCHHHHH		25.3222369663
441PhosphorylationFKQAGSPSSTVSSLA
EECCCCCCHHHHHHH		40.1022369663
442PhosphorylationKQAGSPSSTVSSLAK
ECCCCCCHHHHHHHH		35.8922369663
443PhosphorylationQAGSPSSTVSSLAKC
CCCCCCHHHHHHHHH		28.8322369663
449UbiquitinationSTVSSLAKCLEKDYI
HHHHHHHHHHHCCCC		44.6523749301
453AcetylationSLAKCLEKDYIPVSR
HHHHHHHCCCCCHHH		42.7725381059
503AcetylationLETDSAEKWYGTAYK
CCCCCHHHHCCEEEE		45.4924489116
520AcetylationDYPADLIKNMKSPGL
CCCHHHHHHCCCCCC		59.2824489116
524PhosphorylationDLIKNMKSPGLNPAL
HHHHHCCCCCCCCCC		17.2722369663
532PhosphorylationPGLNPALTLPRPNEF
CCCCCCCCCCCCCCC		36.5022369663
541PhosphorylationPRPNEFVSTNFKVDK
CCCCCCCCCCCEEEE		23.9722369663
542PhosphorylationRPNEFVSTNFKVDKI
CCCCCCCCCCEEEEC		39.1022369663
710AcetylationRSWSTAEKLQVFEKL
CCCCHHHHHHHHHHC		41.5824489116
893AcetylationMPEEDFEKHKEALCN
CCHHHHHHHHHHHHH		61.0324489116
972UbiquitinationLKSQVENKELNENEL
HHHHHCCCCCCHHHC		50.5023749301
983UbiquitinationENELDTAKYPTGQLI
HHHCCCCCCCCCCHH		54.5823749301
1026PhosphorylationKLNNSSESE------
CCCCCCCCC------		51.0228889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of STE23_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STE23_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STE23_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
URE2_YEASTURE2physical
18719252
RL17B_YEASTRPL17Bgenetic
27708008
PFKA2_YEASTPFK2genetic
27708008
DIA2_YEASTDIA2genetic
27708008
COX4_YEASTCOX4physical
28228553
CYM1_YEASTCYM1genetic
28228553
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STE23_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439, AND MASSSPECTROMETRY.

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