CYM1_YEAST - dbPTM
CYM1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CYM1_YEAST
UniProt AC P32898
Protein Name Mitochondrial presequence protease
Gene Name CYM1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 989
Subcellular Localization Mitochondrion intermembrane space . May also be present in the mitochondrial matrix.
Protein Description ATP-independent protease that degrades mitochondrial transit peptides after their cleavage both in intermembrane space and in matrix. Also degrades other unstructured peptides (By similarity)..
Protein Sequence MLRFQRFASSYAQAQAVRKYPVGGIFHGYEVRRILPVPELRLTAVDLVHSQTGAEHLHIDRDDKNNVFSIAFKTNPPDSTGVPHILEHTTLCGSVKYPVRDPFFKMLNKSLANFMNAMTGPDYTFFPFSTTNPQDFANLRGVYLDSTLNPLLKQEDFDQEGWRLEHKNITDPESNIVFKGVVYNEMKGQISNANYYFWSKFQQSIYPSLNNSGGDPMKITDLRYGDLLDFHHKNYHPSNAKTFTYGNLPLVDTLKQLNEQFSGYGKRARKDKLLMPIDLKKDIDVKLLGQIDTMLPPEKQTKASMTWICGAPQDTYDTFLLKVLGNLLMDGHSSVMYQKLIESGIGLEFSVNSGVEPTTAVNLLTVGIQGVSDIEIFKDTVNNIFQNLLETEHPFDRKRIDAIIEQLELSKKDQKADFGLQLLYSILPGWTNKIDPFESLLFEDVLQRFRGDLETKGDTLFQDLIRKYIVHKPCFTFSIQGSEEFSKSLDDEEQTRLREKITALDEQDKKNIFKRGILLQEKQNEKEDLSCLPTLQIKDIPRAGDKYSIEQKNNTMSRITDTNGITYVRGKRLLNDIIPFELFPYLPLFAESLTNLGTTTESFSEIEDQIKLHTGGISTHVEVTSDPNTTEPRLIFGFDGWSLNSKTDHIFEFWSKILLETDFHKNSDKLKVLIRLLASSNTSSVADAGHAFARGYSAAHYRSSGAINETLNGIEQLQFINRLHSLLDNEETFQREVVDKLTELQKYIVDTNNMNFFITSDSDVQAKTVESQISKFMERLPHGSCLPNGPKTSDYPLIGSKCKHTLIKFPFQVHYTSQALLGVPYTHKDGSALQVMSNMLTFKHLHREVREKGGAYGGGASYSALAGIFSFYSYRDPQPLKSLETFKNSGRYILNDAKWGVTDLDEAKLTIFQQVDAPKSPKGEGVTYFMSGVTDDMKQARREQLLDVSLLDVHRVAEKYLLNKEGVSTVIGPGIEGKTVSPNWEVKEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
29PhosphorylationVGGIFHGYEVRRILP
CCCEECCEEEEEEEE		11.5928889911
105AcetylationPVRDPFFKMLNKSLA
CCCCHHHHHHHHHHH		42.7424489116
167AcetylationEGWRLEHKNITDPES
CCCEEEECCCCCCCC		40.4424489116
665AcetylationLLETDFHKNSDKLKV
HHHCCCCCCHHHHHH		59.1324489116
775AcetylationTVESQISKFMERLPH
HHHHHHHHHHHHCCC		50.8124489116
831PhosphorylationPYTHKDGSALQVMSN
CCCCCCCCHHHHHHH		35.6227017623
887AcetylationLKSLETFKNSGRYIL
CCCHHHHHHCCCEEE		58.5922865919
920PhosphorylationQQVDAPKSPKGEGVT
EECCCCCCCCCCCCE		30.6817330950
927PhosphorylationSPKGEGVTYFMSGVT
CCCCCCCEEEECCCC		23.1521440633
928PhosphorylationPKGEGVTYFMSGVTD
CCCCCCEEEECCCCH		8.5520377248
938AcetylationSGVTDDMKQARREQL
CCCCHHHHHHHHHHH		48.0424489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CYM1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CYM1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CYM1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HSP42_YEASTHSP42physical
11805826
ODP2_YEASTLAT1physical
11805826
DLDH_YEASTLPD1physical
11805826
ODPA_YEASTPDA1physical
11805826
ODPB_YEASTPDB1physical
11805826
ODPX_YEASTPDX1physical
11805826
YME1_YEASTYME1genetic
15772085
HSP42_YEASTHSP42physical
16429126
ODP2_YEASTLAT1physical
16429126
DLDH_YEASTLPD1physical
16429126
ODPA_YEASTPDA1physical
16429126
ODPB_YEASTPDB1physical
16429126
ODPX_YEASTPDX1physical
16429126
UAP1_YEASTQRI1genetic
27708008
UBC3_YEASTCDC34genetic
27708008
CDC37_YEASTCDC37genetic
27708008
CDC4_YEASTCDC4genetic
27708008
SPC97_YEASTSPC97genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
MPPB_YEASTMAS1genetic
27708008
RNT1_YEASTRNT1genetic
27708008
NUF2_YEASTNUF2genetic
27708008
CH10_YEASTHSP10genetic
27708008
NAB3_YEASTNAB3genetic
27708008
PIN4_YEASTPIN4genetic
27708008
RV161_YEASTRVS161genetic
27708008
RIM1_YEASTRIM1genetic
27708008
PAT1_YEASTPAT1genetic
27708008
NHP10_YEASTNHP10genetic
27708008
TPS2_YEASTTPS2genetic
27708008
VPS41_YEASTVPS41genetic
27708008
RM01_YEASTMRPL1genetic
27708008
VHS1_YEASTVHS1genetic
27708008
ICP55_YEASTICP55genetic
27708008
ODPA_YEASTPDA1genetic
27708008
YFF4_YEASTYFL054Cgenetic
27708008
ILM1_YEASTILM1genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
AIM26_YEASTAIM26genetic
27708008
MDL1_YEASTMDL1genetic
27708008
EIS1_YEASTEIS1genetic
27708008
TMA23_YEASTTMA23genetic
27708008
LSM7_YEASTLSM7genetic
27708008
TRM44_YEASTTRM44genetic
27708008
PET20_YEASTPET20genetic
27708008
STE23_YEASTSTE23genetic
28228553
MPPB_YEASTMAS1genetic
25176146
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CYM1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-920, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-920, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-920, AND MASSSPECTROMETRY.

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