ODPX_YEAST - dbPTM
ODPX_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ODPX_YEAST
UniProt AC P16451
Protein Name Pyruvate dehydrogenase complex protein X component, mitochondrial
Gene Name PDX1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 410
Subcellular Localization Mitochondrion matrix.
Protein Description Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex..
Protein Sequence MLSAISKVSTLKSCTRYLTKCNYHASAKLLAVKTFSMPAMSPTMEKGGIVSWKYKVGEPFSAGDVILEVETDKSQIDVEALDDGKLAKILKDEGSKDVDVGEPIAYIADVDDDLATIKLPQEANTANAKSIEIKKPSADSTEATQQHLKKATVTPIKTVDGSQANLEQTLLPSVSLLLAENNISKQKALKEIAPSGSNGRLLKGDVLAYLGKIPQDSVNKVTEFIKKNERLDLSNIKPIQLKPKIAEQAQTKAADKPKITPVEFEEQLVFHAPASIPFDKLSESLNSFMKEAYQFSHGTPLMDTNSKYFDPIFEDLVTLSPREPRFKFSYDLMQIPKANNMQDTYGQEDIFDLLTGSDATASSVRPVEKNLPEKNEYILALNVSVNNKKFNDAEAKAKRFLDYVRELESF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
34PhosphorylationAKLLAVKTFSMPAMS
HHEEEEEEECCCCCC		17.8430377154
36PhosphorylationLLAVKTFSMPAMSPT
EEEEEEECCCCCCCC		29.1427017623
41PhosphorylationTFSMPAMSPTMEKGG
EECCCCCCCCCCCCC		21.2327017623
43PhosphorylationSMPAMSPTMEKGGIV
CCCCCCCCCCCCCEE		30.5627017623
46AcetylationAMSPTMEKGGIVSWK
CCCCCCCCCCEEEEE		52.1724489116
53AcetylationKGGIVSWKYKVGEPF
CCCEEEEEEECCCCC		27.9022865919
73N6-lipoyllysineILEVETDKSQIDVEA
EEEEECCHHHCCCEE		52.24-
73LipoylationILEVETDKSQIDVEA
EEEEECCHHHCCCEE		52.24-
73LipoylationILEVETDKSQIDVEA
EEEEECCHHHCCCEE		52.24-
96AcetylationILKDEGSKDVDVGEP
HHCCCCCCCCCCCCC		73.0424489116
149AcetylationEATQQHLKKATVTPI
HHHHHHHHHCCCCCC		37.9322865919
154PhosphorylationHLKKATVTPIKTVDG
HHHHCCCCCCEECCC		18.2327214570
190AcetylationISKQKALKEIAPSGS
CCHHHHHHHHCCCCC		52.5122865919
212AcetylationDVLAYLGKIPQDSVN
CHHHHCCCCCHHHHH		48.9324489116
237AcetylationRLDLSNIKPIQLKPK
CCCCCCCCCCCCCHH		40.0824489116
242AcetylationNIKPIQLKPKIAEQA
CCCCCCCCHHHHHHH		28.0824489116
299PhosphorylationAYQFSHGTPLMDTNS
HHHHHCCCCCCCCCC		14.0721440633
318PhosphorylationPIFEDLVTLSPREPR
HHHHHHCCCCCCCCC		28.9021440633
320PhosphorylationFEDLVTLSPREPRFK
HHHHCCCCCCCCCCC		16.7322369663
327AcetylationSPREPRFKFSYDLMQ
CCCCCCCCCEEECCC		34.3824489116
344PhosphorylationKANNMQDTYGQEDIF
CCCCCCCCCCCHHHH		16.8021440633
345PhosphorylationANNMQDTYGQEDIFD
CCCCCCCCCCHHHHH		25.7121440633
363PhosphorylationGSDATASSVRPVEKN
CCCCCHHCCCCCHHC		21.4921440633
389AcetylationNVSVNNKKFNDAEAK
EEEECCCCCCHHHHH		52.0725381059
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ODPX_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ODPX_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ODPX_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DLDH_YEASTLPD1physical
16429126
ODPB_YEASTPDB1physical
16429126
ODPX_YEASTPDX1physical
19523954
TXTP_YEASTCTP1genetic
21623372
ACH1_YEASTACH1genetic
21623372
ARGJ_YEASTARG7genetic
21623372
ADH3_YEASTADH3genetic
21623372
HFA1_YEASTHFA1genetic
21623372
BOS1_YEASTBOS1genetic
27708008
SLX5_YEASTSLX5genetic
27708008
KPC1_YEASTPKC1genetic
27708008
APC11_YEASTAPC11genetic
27708008
LCB2_YEASTLCB2genetic
27708008
ACT_YEASTACT1genetic
27708008
KTHY_YEASTCDC8genetic
27708008
ERO1_YEASTERO1genetic
27708008
LCB1_YEASTLCB1genetic
27708008
NOP2_YEASTNOP2genetic
27708008
PROF_YEASTPFY1genetic
27708008
TIM50_YEASTTIM50genetic
27708008
ACH1_YEASTACH1genetic
27708008
GID4_YEASTVID24genetic
27708008
TXTP_YEASTCTP1genetic
27708008
CISY2_YEASTCIT2genetic
27708008
NHP10_YEASTNHP10genetic
27708008
PEX19_YEASTPEX19genetic
27708008
IMP2_YEASTIMP2genetic
27708008
ATP23_YEASTATP23genetic
27708008
ALDH6_YEASTALD6genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ODPX_YEAST

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Related Literatures of Post-Translational Modification

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