| UniProt ID | LCB2_YEAST | |
|---|---|---|
| UniProt AC | P40970 | |
| Protein Name | Serine palmitoyltransferase 2 | |
| Gene Name | LCB2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 561 | |
| Subcellular Localization |
Cytoplasm. Endoplasmic reticulum. Membrane Multi-pass membrane protein . |
|
| Protein Description | Catalytic subunit of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine.. | |
| Protein Sequence | MSTPANYTRVPLCEPEELPDDIQKENEYGTLDSPGHLYQVKSRHGKPLPEPVVDTPPYYISLLTYLNYLILIILGHVHDFLGMTFQKNKHLDLLEHDGLAPWFSNFESFYVRRIKMRIDDCFSRPTTGVPGRFIRCIDRISHNINEYFTYSGAVYPCMNLSSYNYLGFAQSKGQCTDAALESVDKYSIQSGGPRAQIGTTDLHIKAEKLVARFIGKEDALVFSMGYGTNANLFNAFLDKKCLVISDELNHTSIRTGVRLSGAAVRTFKHGDMVGLEKLIREQIVLGQPKTNRPWKKILICAEGLFSMEGTLCNLPKLVELKKKYKCYLFIDEAHSIGAMGPTGRGVCEIFGVDPKDVDILMGTFTKSFGAAGGYIAADQWIIDRLRLDLTTVSYSESMPAPVLAQTISSLQTISGEICPGQGTERLQRIAFNSRYLRLALQRLGFIVYGVADSPVIPLLLYCPSKMPAFSRMMLQRRIAVVVVAYPATPLIESRVRFCMSASLTKEDIDYLLRHVSEVGDKLNLKSNSGKSSYDGKRQRWDIEEVIRRTPEDCKDDKYFVN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 28 | Phosphorylation | DIQKENEYGTLDSPG HHHHHCCCCCCCCCC | 27.30 | 22369663 | |
| 30 | Phosphorylation | QKENEYGTLDSPGHL HHHCCCCCCCCCCCE | 26.87 | 22369663 | |
| 33 | Phosphorylation | NEYGTLDSPGHLYQV CCCCCCCCCCCEEEE | 35.57 | 22369663 | |
| 38 | Phosphorylation | LDSPGHLYQVKSRHG CCCCCCEEEEECCCC | 12.94 | 22369663 | |
| 41 | Acetylation | PGHLYQVKSRHGKPL CCCEEEEECCCCCCC | 26.67 | 24489116 | |
| 123 | Phosphorylation | MRIDDCFSRPTTGVP EECHHHCCCCCCCCC | 43.62 | 27214570 | |
| 127 | Phosphorylation | DCFSRPTTGVPGRFI HHCCCCCCCCCCHHH | 38.57 | 25533186 | |
| 172 | Ubiquitination | YLGFAQSKGQCTDAA CCCCCCCCCCCCHHH | 40.70 | 17644757 | |
| 185 | Ubiquitination | AALESVDKYSIQSGG HHHHHHHHHHHHCCC | 38.45 | 17644757 | |
| 205 | Acetylation | GTTDLHIKAEKLVAR CCCCHHHHHHHHHHH | 39.48 | 24489116 | |
| 239 | Ubiquitination | LFNAFLDKKCLVISD HHHHHCCCCEEEEEC | 47.75 | 17644757 | |
| 240 | Ubiquitination | FNAFLDKKCLVISDE HHHHCCCCEEEEECC | 32.25 | 17644757 | |
| 277 | Acetylation | GDMVGLEKLIREQIV CCCCCHHHHHHHHHH | 55.01 | 24489116 | |
| 366 | N6-(pyridoxal phosphate)lysine | ILMGTFTKSFGAAGG EEEEECCCCCCCCCC | 39.33 | - | |
| 366 | Other | ILMGTFTKSFGAAGG EEEEECCCCCCCCCC | 39.33 | - | |
| 521 | Ubiquitination | HVSEVGDKLNLKSNS HHHHHCHHCCCCCCC | 33.09 | 17644757 | |
| 525 | Ubiquitination | VGDKLNLKSNSGKSS HCHHCCCCCCCCCCC | 46.66 | 17644757 | |
| 526 | Phosphorylation | GDKLNLKSNSGKSSY CHHCCCCCCCCCCCC | 39.12 | 27017623 | |
| 532 | Phosphorylation | KSNSGKSSYDGKRQR CCCCCCCCCCCCCCC | 30.63 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LCB2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LCB2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LCB2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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