dbPTM

SFH5_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SFH5_YEAST
UniProt AC	P47008
Protein Name	Phosphatidylinositol transfer protein SFH5
Gene Name	SFH5
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	294
Subcellular Localization	Cytoplasm . Endoplasmic reticulum membrane Peripheral membrane protein . Microsome membrane Peripheral membrane protein .
Protein Description	Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane..
Protein Sequence	MKFDNDSEKQVFDKLKKAIPGIIKEKCAGYDELYGYKLNPEGLTQEEVDKYYDEKIADRLTYKLCKAYQFEYSTIVQNLIDILNWRREFNPLSCAYKEVHNTELQNVGILTFDANGDANKKAVTWNLYGQLVKKKELFQNVDKFVRYRIGLMEKGLSLLDFTSSDNNYMTQVHDYKGVSVWRMDSDIKNCSKTVIGIFQKYYPELLYAKYFVNVPTVFGWVYDLIKKFVDETTRKKFVVLTDGSKLGQYLKDCPYEGYGGKDKKNNLTKQNVTNVHPTEYGLYILQKQIIEDVE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Ubiquitination	QVFDKLKKAIPGIIK HHHHHHHHHCCHHHH	63.08	23749301
50	Ubiquitination	LTQEEVDKYYDEKIA CCHHHHHHHHCHHHH	51.38	23749301
55	Acetylation	VDKYYDEKIADRLTY HHHHHCHHHHHHHHH	40.05	24489116
143	Acetylation	ELFQNVDKFVRYRIG HHHHCHHHHHHHHHH	41.29	24489116
191	Phosphorylation	DSDIKNCSKTVIGIF CCCHHHCCHHHHHHH	40.53	19779198
245	Acetylation	VVLTDGSKLGQYLKD EEECCCHHHHHHHHC	63.27	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SFH5_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SFH5_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SFH5_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
PDR8_YEAST	PDR8	physical	18719252

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SFH5_YEAST

Related Literatures of Post-Translational Modification